Search Results - "Lessard, Martine"
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Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
Published in Nature communications (31-01-2019)“…The role of microglia in spinal cord injury (SCI) remains poorly understood and is often confused with the response of macrophages. Here, we use specific…”
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The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury
Published in Nature communications (02-10-2022)“…Spinal cord injury (SCI) triggers neuroinflammation, and subsequently secondary degeneration and oligodendrocyte (OL) death. We report that the alarmin…”
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Effects of myeloablation, peripheral chimerism, and whole-body irradiation on the entry of bone marrow-derived cells into the brain
Published in Cell transplantation (01-06-2012)“…Understanding how bone marrow-derived cells (BMDCs) enter the central nervous system (CNS) is critical for the development of therapies for brain-related…”
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Powerful beneficial effects of macrophage colony-stimulating factor on β-amyloid deposition and cognitive impairment in Alzheimer's disease
Published in Brain (London, England : 1878) (01-04-2009)“…Alzheimer's disease is a major cause of dementia in humans. The appearance of cognitive decline is linked to the overproduction of a short peptide called…”
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Powerful beneficial effects of macrophage colony-stimulating factor on -amyloid deposition and cognitive impairment in Alzheimer's disease
Published in Brain (London, England : 1878) (01-04-2009)“…Alzheimer's disease is a major cause of dementia in humans. The appearance of cognitive decline is linked to the overproduction of a short peptide called…”
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IL-1α Gene Deletion Protects Oligodendrocytes after Spinal Cord Injury through Upregulation of the Survival Factor Tox3
Published in The Journal of neuroscience (29-07-2015)“…Spinal cord injury (SCI) causes the release of danger signals by stressed and dying cells, a process that leads to neuroinflammation. Evidence suggests that…”
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Hormonal and Feedback Regulation of Putrescine and Spermidine Transport in Human Breast Cancer Cells (∗)
Published in The Journal of biological chemistry (27-01-1995)“…The properties and regulation of the mammalian polyamine transport system are still poorly understood. In estrogen-responsive ZR-75-1 human breast cancer…”
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Inorganic Cation Dependence of Putrescine and Spermidine Transport in Human Breast Cancer Cells (∗)
Published in The Journal of biological chemistry (27-01-1995)“…The mechanism of polyamine uptake in mammalian cells is still poorly understood. The role of inorganic cations in polyamine transport was investigated in…”
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Irradiation Does Not Compromise or Exacerbate the Innate Immune Response in the Brains of Mice That Were Transplanted with Bone Marrow Stem Cells
Published in Stem cells (Dayton, Ohio) (01-12-2007)“…Microglia and invading macrophages play key roles in the brain immune response. The contributions of these two populations of cells in health and diseases have…”
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