Search Results - "Lesnick, Timothy G."

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers by Jack, Clifford R, Prof Dr, Knopman, David S, Prof, Jagust, William J, Prof, Petersen, Ronald C, Prof, Weiner, Michael W, Prof, Aisen, Paul S, Prof, Shaw, Leslie M, Prof, Vemuri, Prashanthi, PhD, Wiste, Heather J, Weigand, Stephen D, Lesnick, Timothy G, Pankratz, Vernon S, PhD, Donohue, Michael C, PhD, Trojanowski, John Q, Prof

“…Summary In 2010, we put forward a hypothetical model of the major biomarkers of Alzheimer's disease (AD). The model was received with interest because we…”
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Age, vascular health, and Alzheimer disease biomarkers in an elderly sample by Vemuri, Prashanthi, Lesnick, Timothy G., Przybelski, Scott A., Knopman, David S., Lowe, Val J., Graff‐Radford, Jonathan, Roberts, Rosebud O., Mielke, Michelle M., Machulda, Mary M., Petersen, Ronald C., Jack, Clifford R.

“…Objective To investigate the associations between age, vascular health, and Alzheimer disease (AD) imaging biomarkers in an elderly sample. Methods We…”
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Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly by Vemuri, Prashanthi, Lesnick, Timothy G, Przybelski, Scott A, Knopman, David S, Preboske, Greg M, Kantarci, Kejal, Raman, Mekala R, Machulda, Mary M, Mielke, Michelle M, Lowe, Val J, Senjem, Matthew L, Gunter, Jeffrey L, Rocca, Walter A, Roberts, Rosebud O, Petersen, Ronald C, Jack, Jr, Clifford R

“…Our primary objective was to investigate a biomarker driven model for the interrelationships between vascular disease pathology, amyloid pathology, and…”
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Evaluation of Amyloid Protective Factors and Alzheimer Disease Neurodegeneration Protective Factors in Elderly Individuals by Vemuri, Prashanthi, Knopman, David S, Lesnick, Timothy G, Przybelski, Scott A, Mielke, Michelle M, Graff-Radford, Jonathan, Murray, Melissa E, Roberts, Rosebud O, Vassilaki, Maria, Lowe, Val J, Machulda, Mary M, Jones, David T, Petersen, Ronald C, Jack, Jr, Clifford R

“…While amyloid and neurodegeneration are viewed together as Alzheimer disease pathophysiology (ADP), the factors that influence amyloid and AD-pattern…”
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Effect of lifestyle activities on alzheimer disease biomarkers and cognition by Vemuri, Prashanthi, Lesnick, Timothy G., Przybelski, Scott A., Knopman, David S., Roberts, Rosebud O., Lowe, Val J., Kantarci, Kejal, Senjem, Mathew L., Gunter, Jeffrey L., Boeve, Bradley F., Petersen, Ronald C., Jack Jr, Clifford R.

“…Objective: A study was undertaken to investigate the association of intellectual and physical activity with biomarkers of Alzheimer disease (AD)…”
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High-Resolution Whole-Genome Association Study of Parkinson Disease by Maraganore, Demetrius M., de Andrade, Mariza, Lesnick, Timothy G., Strain, Kari J., Farrer, Matthew J., Rocca, Walter A., Pant, P.V. Krishna, Frazer, Kelly A., Cox, David R., Ballinger, Dennis G.

“…We performed a two-tiered, whole-genome association study of Parkinson disease (PD). For tier 1, we individually genotyped 198,345 uniformly spaced and…”
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Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics by Lin, Ling, Lesnick, Timothy G, Maraganore, Demetrius M, Isacson, Ole

“…Axon-guidance-pathway molecules are involved in connectivity and repair throughout life (beyond guiding brain wiring during fetal development). One study found…”
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Association of plasma glial fibrillary acidic protein (GFAP) with neuroimaging of Alzheimer's disease and vascular pathology by Shir, Dror, Graff‐Radford, Jonathan, Hofrenning, Ekaterina I., Lesnick, Timothy G., Przybelski, Scott A., Lowe, Val J., Knopman, David S., Petersen, Ronald C., Jack, Clifford R., Vemuri, Prashanthi, Algeciras‐Schimnich, Alicia, Campbell, Michelle R., Stricker, Nikki H., Mielke, Michelle M.

“…Introduction: Plasma glial fibrillary acidic protein (GFAP) may be associated with amyloid burden, neurodegeneration, and stroke but its specificity for…”
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A genomic pathway approach to a complex disease: axon guidance and Parkinson disease by Lesnick, Timothy G, Papapetropoulos, Spiridon, Mash, Deborah C, Ffrench-Mullen, Jarlath, Shehadeh, Lina, de Andrade, Mariza, Henley, John R, Rocca, Walter A, Ahlskog, J Eric, Maraganore, Demetrius M

“…While major inroads have been made in identifying the genetic causes of rare Mendelian disorders, little progress has been made in the discovery of common gene…”
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Transfusion-related acute lung injury and pulmonary edema in critically ill patients: a retrospective study by Rana, Rimki, Fernández-Pérez, Evans R., Khan, S. Anjum, Rana, Sameer, Winters, Jeffrey L., Lesnick, Timothy G., Moore, S. Breanndan, Gajic, Ognjen

“…BACKGROUND: Using the recent Consensus Panel recommendations, we sought to describe the incidence of transfusion‐related acute lung injury (TRALI) and…”
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Longitudinal Association Between Brain Amyloid-Beta and Gait in the Mayo Clinic Study of Aging by Wennberg, Alexandra M V, Lesnick, Timothy G, Schwarz, Christopher G, Savica, Rodolfo, Hagen, Clinton E, Roberts, Rosebud O, Knopman, David S, Hollman, John H, Vemuri, Prashanthi, Jack, Clifford R, Petersen, Ronald C, Mielke, Michelle M

“…Abstract Background The longitudinal association between cerebral amyloid-beta (Aβ) and change in gait, and whether this association is mediated by cortical…”
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Thrombogenic microvesicles and white matter hyperintensities in postmenopausal women by RAZ, Limor, JAYACHANDRAN, M, MILLER, Virginia M, KANTARCI, Kejal, TOSAKULWONG, Nirubol, LESNICK, Timothy G, WILLE, Samantha M, MURPHY, Matthew C, SENJEM, Matthew L, GUNTER, Jeffrey L, VEMURI, Prashanthi, JACK, Clifford R

“…To determine the association of conventional cardiovascular risk factors, markers of platelet activation, and thrombogenic blood-borne microvesicles with white…”
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FDG PET metabolic signatures distinguishing prodromal DLB and prodromal AD by Kantarci, Kejal, Boeve, Bradley F., Przybelski, Scott A., Lesnick, Timothy G., Chen, Qin, Fields, Julie, Schwarz, Christopher G., Senjem, Matthew L., Gunte, Jeffrey L., Jack, Clifford R., Min, Paul, Jain, Manoj, Miyagawa, Toji, Savica, Rodolfo, Graff-Radford, Jonathan, Botha, Hugo, Jones, David T., Knopman, David S., Graff-Radford, Neill, Ferman, Tanis J., Petersen, Ronald C., Lowe, Val J.

“…•FDG PET distinguish prodromal DLB from prodromal Alzheimer’s disease.•The topography of hypometabolism in prodromal DLB is consistent with DLB pattern.•Medial…”
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MRI quantitative susceptibility mapping of the substantia nigra as an early biomarker for Lewy body disease by Chen, Qin, Boeve, Bradley F., Forghanian‐Arani, Arvin, Senjem, Matthew L., Jack, Clifford R., Przybelski, Scott A., Lesnick, Timothy G., Kremers, Walter K., Fields, Julie A., Schwarz, Christopher G., Gunter, Jeffrey L., Trzasko, Joshua D., Graff‐Radford, Jonathan, Savica, Rodolfo, Knopman, David S., Dickson, Dennis W., Ferman, Tanis J., Graff‐Radford, Neill, Petersen, Ronald C., Kantarci, Kejal

“…ABSTRACT Background and Purpose Neurodegeneration of the substantia nigra in Lewy body disease is associated with iron deposition, which increases the magnetic…”
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Causal structure discovery identifies risk factors and early brain markers related to evolution of white matter hyperintensities by Shen, Xinpeng, Raghavan, Sheelakumari, Przybelski, Scott A., Lesnick, Timothy G., Ma, Sisi, Reid, Robert I., Graff-Radford, Jonathan, Mielke, Michelle M., Knopman, David S., Petersen, Ronald C., Jack Jr, Clifford R., Simon, György J., Vemuri, Prashanthi

“…[Display omitted] •White matter health mediates the effect of vascular health on white matter hyperintensity.•Midlife physical activities and smoking status…”
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Aortic hemodynamics and white matter hyperintensities in normotensive postmenopausal women by Barnes, Jill N., Harvey, Ronée E., Zuk, Samantha M., Lundt, Emily S., Lesnick, Timothy G., Gunter, Jeffrey L., Senjem, Matthew L., Shuster, Lynne T., Miller, Virginia M., Jack, Clifford R., Joyner, Michael J., Kantarci, Kejal

“…Hypertension is associated with development of white matter hyperintensities (WMH) in the brain, which are risk factors for mild cognitive impairment. Hormonal…”
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Complex relationships of socioeconomic status with vascular and Alzheimer’s pathways on cognition by Shir, Dror, Graff-Radford, Jonathan, Fought, Angela J., Lesnick, Timothy G., Przybelski, Scott A., Vassilaki, Maria, Lowe, Val J., Knopman, David S., Machulda, Mary M., Petersen, Ronald C., Jack, Clifford R., Mielke, Michelle M., Vemuri, Prashanthi

“…[Display omitted] •AD and CVD often co-exists and are leading causes of age-related cognitive decline.•We used SEM modeling to study the effects of vascular…”
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Relationship Between Risk Factors and Brain Reserve in Late Middle Age: Implications for Cognitive Aging by Neth, Bryan J, Graff-Radford, Jonathan, Mielke, Michelle M, Przybelski, Scott A, Lesnick, Timothy G, Schwarz, Christopher G, Reid, Robert I, Senjem, Matthew L, Lowe, Val J, Machulda, Mary M, Petersen, Ronald C, Jack, Jr, Clifford R, Knopman, David S, Vemuri, Prashanthi

“…Brain reserve can be defined as the individual variation in the brain structural characteristics that later in life are likely to modulate cognitive…”
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Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer's pathophysiology by Ramanan, Vijay K, Lesnick, Timothy G, Przybelski, Scott A, Heckman, Michael G, Knopman, David S, Graff-Radford, Jonathan, Lowe, Val J, Machulda, Mary M, Mielke, Michelle M, Jack, Jr, Clifford R, Petersen, Ronald C, Ross, Owen A, Vemuri, Prashanthi

“…Although abnormal accumulation of amyloid in the brain is an early biomarker of Alzheimer's disease (AD), wide variation in cognitive trajectories during life…”
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White matter damage due to vascular, tau, and TDP-43 pathologies and its relevance to cognition by Raghavan, Sheelakumari, Przybelski, Scott A, Reid, Robert I, Lesnick, Timothy G, Ramanan, Vijay K, Botha, Hugo, Matchett, Billie J, Murray, Melissa E, Reichard, R Ross, Knopman, David S, Graff-Radford, Jonathan, Jones, David T, Lowe, Val J, Mielke, Michelle M, Machulda, Mary M, Petersen, Ronald C, Kantarci, Kejal, Whitwell, Jennifer L, Josephs, Keith A, Jack, Jr, Clifford R, Vemuri, Prashanthi

“…Multi-compartment modelling of white matter microstructure using Neurite Orientation Dispersion and Density Imaging (NODDI) can provide information on white…”
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