Search Results - "Lesniak, Nicholas A"

A Framework for Effective Application of Machine Learning to Microbiome-Based Classification Problems by Topçuoğlu, Begüm D, Lesniak, Nicholas A, Ruffin, 4th, Mack T, Wiens, Jenna, Schloss, Patrick D

“…Machine learning (ML) modeling of the human microbiome has the potential to identify microbial biomarkers and aid in the diagnosis of many diseases such as…”
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The Gut Bacterial Community Potentiates Clostridioides difficile Infection Severity by Lesniak, Nicholas A., Schubert, Alyxandria M., Flynn, Kaitlin J., Leslie, Jhansi L., Sinani, Hamide, Bergin, Ingrid L., Young, Vincent B., Schloss, Patrick D.

“…The severity of Clostridioides difficile infections (CDI) has increased over the last few decades. Patient age, white blood cell count, and creatinine levels…”
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Fecal Short-Chain Fatty Acids Are Not Predictive of Colonic Tumor Status and Cannot Be Predicted Based on Bacterial Community Structure by Sze, Marc A, Topçuoğlu, Begüm D, Lesniak, Nicholas A, Ruffin, 4th, Mack T, Schloss, Patrick D

“…Colonic bacterial populations are thought to have a role in the development of colorectal cancer with some protecting against inflammation and others…”
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Diluted Fecal Community Transplant Restores Clostridioides difficile Colonization Resistance to Antibiotic-Perturbed Murine Communities by Lesniak, Nicholas A., Tomkovich, Sarah, Henry, Andrew, Taylor, Ana, Colovas, Joanna, Bishop, Lucas, McBride, Kathryn, Schloss, Patrick D.

“…Fecal communities transplanted into individuals can eliminate recurrent Clostridioides difficile infection (CDI) with high efficacy. However, this treatment is…”
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The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome by Baxter, Nielson T, Lesniak, Nicholas A, Sinani, Hamide, Schloss, Patrick D, Koropatkin, Nicole M

“…Acarbose is a safe and effective medication for type 2 diabetes that inhibits host glucoamylases to prevent starch digestion in the small intestines and thus…”
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Clearance of Clostridioides difficile Colonization Is Associated with Antibiotic-Specific Bacterial Changes by Lesniak, Nicholas A, Schubert, Alyxandria M, Sinani, Hamide, Schloss, Patrick D

“…The gut bacterial community prevents many pathogens from colonizing the intestine. Previous studies have associated specific bacteria with clearing…”
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Ten simple rules to increase computational skills among biologists with Code Clubs by Hagan, Ada K, Lesniak, Nicholas A, Balunas, Marcy J, Bishop, Lucas, Close, William L, Doherty, Matthew D, Elmore, Amanda G, Flynn, Kaitlin J, Hannigan, Geoffrey D, Koumpouras, Charlie C, Jenior, Matthew L, Kozik, Ariangela J, McBride, Kathryn, Rifkin, Samara B, Stough, Joshua M A, Sovacool, Kelly L, Sze, Marc A, Tomkovich, Sarah, Topcuoglu, Begum D, Schloss, Patrick D

“…Exploratory Science Center, Merck & Co., Inc., Cambridge, Massachusetts, United States of America Affiliation: Department of Microbiology and Immunology,…”
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An Osmotic Laxative Renders Mice Susceptible to Prolonged Clostridioides difficile Colonization and Hinders Clearance by Tomkovich, Sarah, Taylor, Ana, King, Jacob, Colovas, Joanna, Bishop, Lucas, McBride, Kathryn, Royzenblat, Sonya, Lesniak, Nicholas A, Bergin, Ingrid L, Schloss, Patrick D

“…Antibiotics are a major risk factor for Clostridioides difficile infections (CDIs) because of their impact on the microbiota. However, nonantibiotic…”
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The Proton Pump Inhibitor Omeprazole Does Not Promote Clostridioides difficile Colonization in a Murine Model by Tomkovich, Sarah, Lesniak, Nicholas A, Li, Yuan, Bishop, Lucas, Fitzgerald, Madison J, Schloss, Patrick D

“…Proton pump inhibitor (PPI) use has been associated with microbiota alterations and susceptibility to infections (CDIs) in humans. We assessed how PPI…”
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Erratum for Baxter et al., "The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome" by Baxter, Nielson T, Lesniak, Nicholas A, Sinani, Hamide, Schloss, Patrick D, Koropatkin, Nicole M

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Unusual Aerobic Stabilization of Cob(I)alamin by a B12-Trafficking Protein Allows Chemoenzymatic Synthesis of Organocobalamins by Li, Zhu, Lesniak, Nicholas A, Banerjee, Ruma

“…CblC, a B12 trafficking protein, exhibits glutathione transferase and reductive decyanase activities for processing alkylcobalamins and cyanocobalamin,…”
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Coordination chemistry controls the thiol oxidase activity of the B12-trafficking protein CblC by Li, Zhu, Shanmuganathan, Aranganathan, Ruetz, Markus, Yamada, Kazuhiro, Lesniak, Nicholas A., Kräutler, Bernhard, Brunold, Thomas C., Koutmos, Markos, Banerjee, Ruma

“…The cobalamin or B12 cofactor supports sulfur and one-carbon metabolism and the catabolism of odd-chain fatty acids, branched-chain amino acids, and…”
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Glutathione-dependent One-electron Transfer Reactions Catalyzed by a B12 Trafficking Protein by Li, Zhu, Gherasim, Carmen, Lesniak, Nicholas A., Banerjee, Ruma

“…CblC is involved in an early step in cytoplasmic cobalamin processing following entry of the cofactor into the cytoplasm. CblC converts the cobalamin cargo…”
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Coordination chemistry controls the thiol oxidase activity of the B 12 -trafficking protein CblC by Li, Zhu, Shanmuganathan, Aranganathan, Ruetz, Markus, Yamada, Kazuhiro, Lesniak, Nicholas A, Kräutler, Bernhard, Brunold, Thomas C, Koutmos, Markos, Banerjee, Ruma

“…The cobalamin or B cofactor supports sulfur and one-carbon metabolism and the catabolism of odd-chain fatty acids, branched-chain amino acids, and cholesterol…”
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Unusual Aerobic Stabilization of Cob(I)alamin by a B 12 -Trafficking Protein Allows Chemoenzymatic Synthesis of Organocobalamins by Li, Zhu, Lesniak, Nicholas A., Banerjee, Ruma

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