Search Results - "Lesniak, Maciej S"

Next-generation antigen-presenting cell immune therapeutics for gliomas by Lee-Chang, Catalina, Lesniak, Maciej S

“…Antigen presentation machinery and professional antigen-presenting cells (APCs) are fundamental for an efficacious immune response against cancers, especially…”
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Macrophages and microglia in glioblastoma: heterogeneity, plasticity, and therapy by Khan, Fatima, Pang, Lizhi, Dunterman, Madeline, Lesniak, Maciej S, Heimberger, Amy B, Chen, Peiwen

“…Glioblastoma (GBM) is the most aggressive tumor in the central nervous system and contains a highly immunosuppressive tumor microenvironment (TME)…”
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Multifunctional nanoparticles for brain tumor imaging and therapy by Cheng, Yu, Morshed, Ramin A., Auffinger, Brenda, Tobias, Alex L., Lesniak, Maciej S.

“…Brain tumors are a diverse group of neoplasms that often carry a poor prognosis for patients. Despite tremendous efforts to develop diagnostic tools and…”
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STING agonist-loaded, CD47/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma by Zhang, Peng, Rashidi, Aida, Zhao, Junfei, Silvers, Caylee, Wang, Hanxiang, Castro, Brandyn, Ellingwood, Abby, Han, Yu, Lopez-Rosas, Aurora, Zannikou, Markella, Dmello, Crismita, Levine, Rebecca, Xiao, Ting, Cordero, Alex, Sonabend, Adam M., Balyasnikova, Irina V., Lee-Chang, Catalina, Miska, Jason, Lesniak, Maciej S.

“…As a key component of the standard of care for glioblastoma, radiotherapy induces several immune resistance mechanisms, such as upregulation of CD47 and PD-L1…”
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The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence by Auffinger, Brenda, Spencer, Drew, Pytel, Peter, Ahmed, Atique U, Lesniak, Maciej S

“…Glioma stem cells (GSCs) constitute a slow-dividing, small population within a heterogeneous glioblastoma. They are able to self-renew, recapitulate a whole…”
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HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma by Miska, Jason, Lee-Chang, Catalina, Rashidi, Aida, Muroski, Megan E., Chang, Alan L., Lopez-Rosas, Aurora, Zhang, Peng, Panek, Wojciech K., Cordero, Alex, Han, Yu, Ahmed, Atique U., Chandel, Navdeep S., Lesniak, Maciej S.

“…The mechanisms by which regulatory T cells (Tregs) migrate to and function within the hypoxic tumor microenvironment are unclear. Our studies indicate that…”
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The Interplay between Glioblastoma and Its Microenvironment by Dapash, Mark, Hou, David, Castro, Brandyn, Lee-Chang, Catalina, Lesniak, Maciej S

“…GBM is the most common primary brain tumor in adults, and the aggressive nature of this tumor contributes to its extremely poor prognosis. Over the years, the…”
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FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis by Cordero, Alex, Kanojia, Deepak, Miska, Jason, Panek, Wojciech K., Xiao, Annie, Han, Yu, Bonamici, Nicolas, Zhou, Weidong, Xiao, Ting, Wu, Meijing, Ahmed, Atique U., Lesniak, Maciej S.

“…Overexpression of human epidermal growth factor receptor 2 (HER2) in breast cancer patients is associated with increased incidence of breast cancer brain…”
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Biofunctionalized magnetic-vortex microdiscs for targeted cancer-cell destruction by Bader, Samuel D, Rajh, Tijana, Rozhkova, Elena A, Novosad, Valentyn, Ulasov, Ilya V, Lesniak, Maciej S, Kim, Dong-Hyun

“…Nanomagnetic materials offer exciting avenues for probing cell mechanics and activating mechanosensitive ion channels, as well as for advancing cancer…”
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Remote Control of Mechanical Forces via Mitochondrial‐Targeted Magnetic Nanospinners for Efficient Cancer Treatment by Chen, Mengwei, Wu, Jiaojiao, Ning, Peng, Wang, Jingjing, Ma, Zuan, Huang, Liqun, Plaza, Gustavo R., Shen, Yajing, Xu, Chang, Han, Yu, Lesniak, Maciej S., Liu, Zhongmin, Cheng, Yu

“…In cells, mechanical forces play a key role in impacting cell behaviors, including adhesion, differentiation, migration, and death. Herein, a 20 nm…”
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Blood-Brain Barrier Permeable Gold Nanoparticles: An Efficient Delivery Platform for Enhanced Malignant Glioma Therapy and Imaging by Cheng, Yu, Dai, Qing, Morshed, Ramin A., Fan, Xiaobing, Wegscheid, Michelle L., Wainwright, Derek A., Han, Yu, Zhang, Lingjiao, Auffinger, Brenda, Tobias, Alex L., Rincón, Esther, Thaci, Bart, Ahmed, Atique U., Warnke, Peter C., He, Chuan, Lesniak, Maciej S.

“…The blood‐brain barrier (BBB) remains a formidable obstacle in medicine, preventing efficient penetration of chemotherapeutic and diagnostic agents to…”
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Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression by Yu, Dou, Khan, Omar F., Suvà, Mario L., Dong, Biqin, Panek, Wojciech K., Xiao, Ting, Wu, Meijing, Han, Yu, Ahmed, Atique U., Balyasnikova, Irina V., Zhang, Hao F., Sun, Cheng, Langer, Robert, Anderson, Daniel G., Lesniak, Maciej S.

“…Brain tumor-initiating cells (BTICs) have been identified as key contributors to therapy resistance, recurrence, and progression of diffuse gliomas,…”
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The art of gene therapy for glioma: a review of the challenging road to the bedside by Tobias, Alex, Ahmed, Atique, Moon, Kyung-Sub, Lesniak, Maciej S

“…Glioblastoma multiforme (GBM) is a highly invasive brain tumour that is unvaryingly fatal in humans despite even aggressive therapeutic approaches such as…”
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Dedifferentiation of Glioma Cells to Glioma Stem-like Cells By Therapeutic Stress-induced HIF Signaling in the Recurrent GBM Model by Lee, Gina, Auffinger, Brenda, Guo, Donna, Hasan, Tanwir, Deheeger, Marc, Tobias, Alex L, Kim, Jeong Yeon, Atashi, Fatemeh, Zhang, Lingjiao, Lesniak, Maciej S, James, C David, Ahmed, Atique U

“…Increasing evidence exposes a subpopulation of cancer cells, known as cancer stem cells (CSCs), to be critical for the progression of several human…”
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A High-Performance Nanobio Photocatalyst for Targeted Brain Cancer Therapy by Rozhkova, Elena A, Ulasov, Ilya, Lai, Barry, Dimitrijevic, Nada M, Lesniak, Maciej S, Rajh, Tijana

“…We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO2 particles covalently tethered to an antibody via a dihydroxybenzene bivalent…”
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Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133(+) glioma stem cells to temozolomide therapy by Ulasov, Ilya V, Nandi, Suvobroto, Dey, Mahua, Sonabend, Adam M, Lesniak, Maciej S

“…Malignant gliomas are currently treated with temozolomide (TMZ), but often exhibit resistance to this agent. CD133(+) cancer stem cells, a population believed…”
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Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma by Chastkofsky, Michael I, Pituch, Katarzyna C, Katagi, Hiroaki, Zannikou, Markella, Ilut, Liliana, Xiao, Ting, Han, Yu, Sonabend, Adam M, Curiel, David T, Bonner, Erin R, Nazarian, Javad, Horbinski, Craig M, James, C David, Saratsis, Amanda M, Hashizume, Rintaro, Lesniak, Maciej S, Balyasnikova, Irina V

“…Diffuse intrinsic pontine glioma (DIPG) is among the deadliest of pediatric brain tumors. Radiotherapy is the standard-of-care treatment for DIPG, but offers…”
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Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression by Khan, Fatima, Lin, Yiyun, Ali, Heba, Pang, Lizhi, Dunterman, Madeline, Hsu, Wen-Hao, Frenis, Katie, Grant Rowe, R., Wainwright, Derek A., McCortney, Kathleen, Billingham, Leah K., Miska, Jason, Horbinski, Craig, Lesniak, Maciej S., Chen, Peiwen

“…Abundant macrophage infiltration and altered tumor metabolism are two key hallmarks of glioblastoma. By screening a cluster of metabolic small-molecule…”
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Intranasal delivery of stem cell-based therapies for the treatment of brain malignancies by Li, Gina, Bonamici, Nicolas, Dey, Mahua, Lesniak, Maciej S, Balyasnikova, Irina V

“…Glioblastoma (GBM) is the most aggressive malignant brain cancer in adults, and its poor prognosis and resistance to the existing standard of care require the…”
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The role of IDO in brain tumor immunotherapy by Zhai, Lijie, Lauing, Kristen L., Chang, Alan L., Dey, Mahua, Qian, Jun, Cheng, Yu, Lesniak, Maciej S., Wainwright, Derek A.

“…Malignant glioma comprises the majority of primary brain tumors. Coincidently, most of those malignancies express an inducible tryptophan catabolic enzyme,…”
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