Search Results - "Lesniak, M S"

The CCL2-CCR4 axis promotes Regulatory T cell trafficking to canine glioma tissues by Panek, W. K., Toedebusch, R. G., Mclaughlin, B. E., Dickinson, P. J., Van Dyke, J. E., Woolard, K. D., Berens, M. E., Lesniak, M. S., Sturges, B. K., Vernau, K. M., Li, C., Miska, J., Toedebusch, Christine M.

“…Purpose Spontaneously occurring glioma in pet dogs is increasingly recognized as a valuable translational model for human glioblastoma. Canine high-grade…”
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Autophagy in glioma cells: An identity crisis with a clinical perspective by Ulasov, I.V., Lenz, G., Lesniak, M.S.

“…Over the last decade, autophagy has emerged as one of the critical cellular systems that control homeostasis. Besides management of normal homeostatic…”
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Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo by Ulasov, I V, Sonabend, A M, Nandi, S, Khramtsov, A, Han, Y, Lesniak, M S

“…Conditionally replicative adenoviruses (CRAds) represent a novel treatment strategy for malignant glioma. Recent studies suggest that the cytopathic effect…”
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Neural stem cells target intracranial glioma to deliver an oncolytic adenovirus in vivo by Tyler, M A, Ulasov, I V, Sonabend, A M, Nandi, S, Han, Y, Marler, S, Roth, J, Lesniak, M S

“…Adenoviral oncolytic virotherapy represents an attractive treatment modality for central nervous system (CNS) neoplasms. However, successful application of…”
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Analysis of glioblastoma tumor coverage by oncolytic virus-loaded neural stem cells using MRI-based tracking and histological reconstruction by Morshed, R A, Gutova, M, Juliano, J, Barish, M E, Hawkins-Daarud, A, Oganesyan, D, Vazgen, K, Yang, T, Annala, A, Ahmed, A U, Aboody, K S, Swanson, K R, Moats, R A, Lesniak, M S

“…In preclinical studies, neural stem cell (NSC)-based delivery of oncolytic virus has shown great promise in the treatment of malignant glioma. Ensuring the…”
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Pharmacokinetic study of neural stem cell-based cell carrier for oncolytic virotherapy: targeted delivery of the therapeutic payload in an orthotopic brain tumor model by Thaci, B, Ahmed, A U, Ulasov, I V, Tobias, A L, Han, Y, Aboody, K S, Lesniak, M S

“…Oncolytic virotherapy is a promising novel therapy for glioblastoma that needs to be optimized before introduced to clinic. The targeting of conditionally…”
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Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy by Auffinger, B, Tobias, A L, Han, Y, Lee, G, Guo, D, Dey, M, Lesniak, M S, Ahmed, A U

“…Glioblastoma multiforme patients have a poor prognosis due to therapeutic resistance and tumor relapse. It has been suggested that gliomas are driven by a rare…”
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Depletion of myeloid-derived suppressor cells during interleukin-12 immunogene therapy does not confer a survival advantage in experimental malignant glioma by Thaci, B, Ahmed, A U, Ulasov, I V, Wainwright, D A, Nigam, P, Auffinger, B, Tobias, A L, Han, Y, Zhang, L, Moon, K-S, Lesniak, M S

“…Myeloid-derived suppressor cells (MDSCs) accumulate in the glioma microenvironment during tumor progression and promote immunosuppression. Interleukin-12…”
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Highly tunable perpendicularly magnetized synthetic antiferromagnets for biotechnology applications by Vemulkar, T, Mansell, R, Petit, D C M C, Cowburn, R P, Lesniak, M S

“…Magnetic micro and nanoparticles are increasingly used in biotechnological applications due to the ability to control their behavior through an externally…”
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Biodistribution of an oncolytic adenovirus after intracranial injection in permissive animals: a comparative study of Syrian hamsters and cotton rats by Sonabend, A M, Ulasov, I V, Han, Y, Rolle, C E, Nandi, S, Cao, D, Tyler, M A, Lesniak, M S

“…Conditionally replicative adenoviruses (CRAds) are often evaluated in mice; however, normal and cancerous mouse tissues are poorly permissive for human CRAds…”
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MicroRNA targeting as a therapeutic strategy against glioma by Auffinger, B, Thaci, B, Ahmed, A, Ulasov, I, Lesniak, M S

“…Glioblastoma multiforme (GBM), the most common and aggressive form of primary brain tumor, presents a dismal prognosis. Current standard therapies are only…”
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Low pressure hydrocephalus and ventriculomegaly: hysteresis, non-linear dynamics, and the benefits of CSF diversion by Lesniak, M. S., Clatterbuck, R. E., Rigamonti, D., Williams, M. A.

“…Low pressure hydrocephalus (LPH) is a rare clinical condition. We report our experience with 10 patients treated at the Johns Hopkins Hospital. We reviewed the…”
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Anti-angiogenic therapy increases intratumoral adenovirus distribution by inducing collagen degradation by Thaci, B, Ulasov, I V, Ahmed, A U, Ferguson, S D, Han, Y, Lesniak, M S

“…Conditionally replicating adenoviruses (CRAd) are a promising class of gene therapy agents that can overcome already known glioblastoma (GBM) resistance…”
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Characterization of infectivity of knob-modified adenoviral vectors in glioma by Paul, C.P.L., Everts, M., Dent, P., Fisher, P.B., Ulasov, I.V., Lesniak, M.S., Stoff-Khalili, M.A., Roth, J.C., Glasgow, J.N., Preuss, M.A., Dirven, C.M.F., Lamfers, M.L.M., Siegal, Gene P., Zhu, Z.B., Curiel, D.T.

“…Malignant gliomas have been a major target for gene therapy and virotherapy, because of their current lack of effective treatment. These approaches remain…”
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Sui generis: gene therapy and delivery systems for the treatment of glioblastoma by Kane, J Robert, Miska, Jason, Young, Jacob S, Kanojia, Deepak, Kim, Julius W, Lesniak, Maciej S

“…Gene therapy offers a multidimensional set of approaches intended to treat and cure glioblastoma (GBM), in combination with the existing standard-of-care…”
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Cytomegalovirus and glioma: putting the cart before the horse by Dey, Mahua, Ahmed, Atique U, Lesniak, Maciej S

“…In 1908, Oluf Bang and Vilhelm Ellerman laid the foundation for theory of oncoviruses by demonstrating that the avian erythroblastosis (a form of chicken…”
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P08.01 Tumor cell subpopulation changes during intracranial glioblastoma patient derived xenograft recurrence following radiation, temozolomide, or combination therapy by Ahmed, A. U., Horbinski, C. M., Stupp, R., Lesniak, M. S., James, C. D.

“…We’ve established a model for recurrent GBM by treating mice bearing previously untreated, luciferase-modified, intracranial GBM PDX, with radiation (RT) (2…”
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Drug delivery to tumors of the central nervous system by Lesniak, Maciej S., Langer, Robert, Brem, Henry

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P11.01 Intranasal delivery of mesenchymal stem cells targets diffuse intrinsic pontine glioma in mouse model by Chastkofsky, M. I., Procissi, D., Yang, C., Goldman, S., Lesniak, M. S., Hashizume, R., Balyasnikova, I. V.

“…Diffuse Intrinsic Pontine Glioma (DIPG) is a high-grade pediatric brainstem glioma afflicting children 7-9 years of age. The anatomic and diffuse…”
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Comparative analysis of paracrine immunotherapy in experimental brain tumors by Lesniak, M S, Sampath, P, DiMeco, F, Viglione, M P, Tyler, B M, Pardoll, D M, Brem, H

“…Local delivery of cytokines has been shown to have a potent antitumor activity against a wide range of malignant brain tumors. In this study, the authors…”
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