Search Results - "Lesner, Nicholas P."

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer by Venkateswaran, Niranjan, Lafita-Navarro, M Carmen, Hao, Yi-Heng, Kilgore, Jessica A, Perez-Castro, Lizbeth, Braverman, Jonathan, Borenstein-Auerbach, Nofit, Kim, Min, Lesner, Nicholas P, Mishra, Prashant, Brabletz, Thomas, Shay, Jerry W, DeBerardinis, Ralph J, Williams, Noelle S, Yilmaz, Omer H, Conacci-Sorrell, Maralice

“…Tumors display increased uptake and processing of nutrients to fulfill the demands of rapidly proliferating cancer cells. Seminal studies have shown that the…”
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A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle by Wang, Xun, Jia, Yuemeng, Zhao, Jiawei, Lesner, Nicholas P, Menezes, Cameron J, Shelton, Spencer D, Venigalla, Siva Sai Krishna, Xu, Jian, Cai, Chunyu, Mishra, Prashant

“…A fundamental issue in regenerative medicine is whether there exist endogenous regulatory mechanisms that limit the speed and efficiency of the repair process…”
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Autosomal recessive progeroid syndrome due to homozygosity for a TOMM7 variant by Garg, Abhimanyu, Keng, Wee-Teik, Chen, Zhenkang, Sathe, Adwait Amod, Xing, Chao, Kailasam, Pavithira Devi, Shao, Yanqiu, Lesner, Nicholas P, Llamas, Claire B, Agarwal, Anil K, Mishra, Prashant

“…Multiple genetic loci have been reported for progeroid syndromes. However, the molecular defects in some extremely rare forms of progeria have yet to be…”
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Differential requirements for mitochondrial electron transport chain components in the adult murine liver by Lesner, Nicholas P, Wang, Xun, Chen, Zhenkang, Frank, Anderson, Menezes, Cameron J, House, Sara, Shelton, Spencer D, Lemoff, Andrew, McFadden, David G, Wansapura, Janaka, DeBerardinis, Ralph J, Mishra, Prashant

“…Mitochondrial electron transport chain (ETC) dysfunction due to mutations in the nuclear or mitochondrial genome is a common cause of metabolic disease in…”
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HIF: a master regulator of nutrient availability and metabolic cross‐talk in the tumor microenvironment by Missiaen, Rindert, Lesner, Nicholas P, Simon, M Celeste

“…A role for hypoxia‐inducible factors (HIFs) in hypoxia‐dependent regulation of tumor cell metabolism has been thoroughly investigated and covered in reviews…”
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Detection of RNA nucleoside modifications with the uridine-specific ribonuclease MC1 from Momordica charantia by Addepalli, Balasubrahmanym, Lesner, Nicholas P, Limbach, Patrick A

“…A codon-optimized recombinant ribonuclease, MC1 is characterized for its uridine-specific cleavage ability to map nucleoside modifications in RNA. The…”
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Emerging metabolomic tools to study cancer metastasis by Nascentes Melo, Luiza Martins, Lesner, Nicholas P, Sabatier, Marie, Ubellacker, Jessalyn M, Tasdogan, Alpaslan

“…Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the role of metabolism during metastasis has been limited by the development…”
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α-ketobutyrate links alterations in cystine metabolism to glucose oxidation in mtDNA mutant cells by Lesner, Nicholas P., Gokhale, Amrita S., Kota, Kalyani, DeBerardinis, Ralph J., Mishra, Prashant

“…Pathogenic mutations in the mitochondrial genome (mtDNA) impair organellar ATP production, requiring mutant cells to activate metabolic adaptations for…”
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Mitochondrial complex I promotes kidney cancer metastasis by Bezwada, Divya, Perelli, Luigi, Lesner, Nicholas P., Cai, Ling, Brooks, Bailey, Wu, Zheng, Vu, Hieu S., Sondhi, Varun, Cassidy, Daniel L., Kasitinon, Stacy, Kelekar, Sherwin, Cai, Feng, Aurora, Arin B., Patrick, McKenzie, Leach, Ashley, Ghandour, Rashed, Zhang, Yuanyuan, Do, Duyen, McDaniel, Phyllis, Sudderth, Jessica, Dumesnil, Dennis, House, Sara, Rosales, Tracy, Poole, Alan M., Lotan, Yair, Woldu, Solomon, Bagrodia, Aditya, Meng, Xiaosong, Cadeddu, Jeffrey A., Mishra, Prashant, Garcia-Bermudez, Javier, Pedrosa, Ivan, Kapur, Payal, Courtney, Kevin D., Malloy, Craig R., Genovese, Giannicola, Margulis, Vitaly, DeBerardinis, Ralph J.

“…Most kidney cancers are metabolically dysfunctional 1 – 4 , but how this dysfunction affects cancer progression in humans is unknown. We infused 13 C-labelled…”
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Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer by Li, Fuming, Liu, Pingyu, Mi, Wen, Li, Liucheng, Anderson, Nicole M, Lesner, Nicholas P, Burrows, Michelle, Plesset, Jacqueline, Majer, Ariana, Wang, Guanlin, Li, Jinyang, Zhu, Lingzhi, Keith, Brian, Simon, M Celeste

“…Availability of the essential amino acid methionine affects cellular metabolism and growth, and dietary methionine restriction has been implicated as a cancer…”
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Lactate metabolism is essential in early-onset mitochondrial myopathy by Chen, Zhenkang, Bordieanu, Bogdan, Kesavan, Rushendhiran, Lesner, Nicholas P, Venigalla, Siva Sai Krishna, Shelton, Spencer D, DeBerardinis, Ralph J, Mishra, Prashant

“…Myopathies secondary to mitochondrial electron transport chain (ETC) dysfunction can result in devastating disease. While the consequences of ETC defects have…”
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Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers by Wang, Xun, Shelton, Spencer D, Bordieanu, Bogdan, Frank, Anderson R, Yi, Yating, Venigalla, Siva Sai Krishna, Gu, Zhimin, Lenser, Nicholas P, Glogauer, Michael, Chandel, Navdeep S, Zhao, Hu, Zhao, Zhiyu, McFadden, David G, Mishra, Prashant

“…Muscle stem cells (MuSCs) experience age-associated declines in number and function, accompanied by mitochondrial electron transport chain (ETC) dysfunction…”
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A mitofusin 2/HIF1[alpha] axis sets a maturation checkpoint in regenerating skeletal muscle by Wang, Xun, Jia, Yuemeng, Zhao, Jiawei, Lesner, Nicholas P, Menezes, Cameron J, Shelton, Spencer D, Venigalla, Siva Sai Krishna, Xu, Jian, Cai, Chunyu, Mishra, Prashant

“…A fundamental issue in regenerative medicine is whether there exist endogenous regulatory mechanisms that limit the speed and efficiency of the repair process…”
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Characterization and Identification of Metabolites in the Oxidation of Nicotinic Acid by Bacillus Niacini by Lesner, Nicholas P., Peterson, Michael T., Snider, Mark J.

“…Abstract only N‐Heterocylic compounds are of environmental concern due to their ubiquitous contamination in groundwater and soil. Nicotinic acid is a simple…”
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Mitochondrial complex I promotes kidney cancer metastasis by Bezwada, Divya, Perelli, Luigi, Lesner, Nicholas P, Cai, Ling, Brooks, Bailey, Wu, Zheng, Vu, Hieu S, Sondhi, Varun, Cassidy, Daniel L, Kasitinon, Stacy, Kelekar, Sherwin, Cai, Feng, Aurora, Arin B, Patrick, McKenzie, Leach, Ashley, Ghandour, Rashed, Zhang, Yuanyuan, Do, Duyen, Mcdaniel, Phyllis, Sudderth, Jessica, Dumesnil, Dennis, House, Sara, Rosales, Tracy, Poole, Alan M, Lotan, Yair, Woldu, Solomon, Bagrodia, Aditya, Meng, Xiaosong, Cadeddu, Jeffrey A, Mishra, Prashant, Garcia-Bermudez, Javier, Pedrosa, Ivan, Kapur, Payal, Courtney, Kevin D, Malloy, Craig R, Genovese, Giannicola, Margulis, Vitaly, DeBerardinis, Ralph J

“…Most kidney cancers are metabolically dysfunctional14, but how this dysfunction affects cancer progression in humans is unknown. We infused 13C-labelled…”
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Abstract B003: Increasing branched-chain amino acid metabolism reduces clear cell renal cell carcinoma growth by Coffey, Nathan J., Riscal, Romain, Skuli, Nicolas, Lesner, Nicholas P., Noji, Michael, Jiang, Christine, Kim, Laura C., Han, Xu, Blair, Megan C., Keith, Brian, Arany, Zoltan, Simon, M. Celeste

“…Abstract North America has the highest incidence of renal cancer in the world with the most common subtype being clear cell renal cell carcinoma (ccRCC)…”
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