Search Results - "Lesner, Adam"

Elastolytic activity is associated with inflammation in bladder cancer by Gruba, Natalia, Stachurski, Lech, Lesner, Adam

“…Abstract Cancer development and progression is often associated with inflammation. Late diagnosis of inflammation that directly leads to the development of…”
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Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases by Hahn, Jonas, Schauer, Christine, Czegley, Christine, Kling, Lasse, Petru, Lenka, Schmid, Benjamin, Weidner, Daniela, Reinwald, Christiane, Biermann, Mona H. C., Blunder, Stefan, Ernst, Jürgen, Lesner, Adam, Bäuerle, Tobias, Palmisano, Ralf, Christiansen, Silke, Herrmann, Martin, Bozec, Aline, Gruber, Robert, Schett, Georg, Hoffmann, Markus H.

“…ABSTRACT Papillon‐Lefèvre syndrome (PLS) is characterized by nonfunctional neutrophil serine proteases (NSPs) and fulminant periodontal inflammation of unknown…”
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Theoretical Investigation of the Coronavirus SARS-CoV-2 (COVID-19) Infection Mechanism and Selectivity by Biskupek, Iga, Sieradzan, Adam, Czaplewski, Cezary, Liwo, Adam, Lesner, Adam, Giełdoń, Artur

“…The SARS-CoV-2 virus, commonly known as COVID-19, first occurred in December 2019 in Wuhan, Hubei Province, China. Since then, it has become a tremendous…”
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Fecal Serine Protease Profiling in Inflammatory Bowel Diseases by Jablaoui, Amin, Kriaa, Aicha, Mkaouar, Héla, Akermi, Nizar, Soussou, Souha, Wysocka, Magdalena, Wołoszyn, Dominika, Amouri, Ali, Gargouri, Ali, Maguin, Emmanuelle, Lesner, Adam, Rhimi, Moez

“…Serine proteases are extensively known to play key roles in many physiological processes. However, their dysregulation is often associated to several diseases…”
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Digestive Inflammation: Role of Proteolytic Dysregulation by Mariaule, Vincent, Kriaa, Aicha, Soussou, Souha, Rhimi, Soufien, Boudaya, Houda, Hernandez, Juan, Maguin, Emmanuelle, Lesner, Adam, Rhimi, Moez

“…Dysregulation of the proteolytic balance is often associated with diseases. Serine proteases and matrix metalloproteases are involved in a multitude of…”
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Serine proteases and metalloproteases are highly increased in irritable bowel syndrome Tunisian patients by Soussou, Souha, Jablaoui, Amin, Mariaule, Vincent, Kriaa, Aicha, Boudaya, Houda, Wysocka, Magdalena, Amouri, Ali, Gargouri, Ali, Lesner, Adam, Maguin, Emmanuelle, Rhimi, Moez

“…Serine proteases are involved in many biological processes and are associated with irritable bowel syndrome (IBS) pathology. An increase in serine protease…”
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A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA by Wong, Alicia, Bryzek, Danuta, Dobosz, Ewelina, Scavenius, Carsten, Svoboda, Pavel, Rapala-Kozik, Maria, Lesner, Adam, Frydrych, Ivo, Enghild, Jan, Mydel, Piotr, Pohl, Jan, Thompson, Paul R, Potempa, Jan, Koziel, Joanna

“…LL-37, the only human cathelicidin that is released during inflammation, is a potent regulator of immune responses by facilitating delivery of oligonucleotides…”
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A Peptidomimetic Fluorescent Probe to Detect the Trypsin β2 Subunit of the Human 20S Proteasome by Wysocka, Magdalena, Romanowska, Anita, Gruba, Natalia, Michalska, Michalina, Giełdoń, Artur, Lesner, Adam

“…This work describes the chemical synthesis, combinatorial selection, and enzymatic evaluation of peptidomimetic fluorescent substrates specific for the…”
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Gut Serpinome: Emerging Evidence in IBD by Mkaouar, Héla, Mariaule, Vincent, Rhimi, Soufien, Hernandez, Juan, Kriaa, Aicha, Jablaoui, Amin, Akermi, Nizar, Maguin, Emmanuelle, Lesner, Adam, Korkmaz, Brice, Rhimi, Moez

“…Inflammatory bowel diseases (IBD) are incurable disorders whose prevalence and global socioeconomic impact are increasing. While the role of host genetics and…”
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Synthesis and Evaluation of Biological Activity of Antimicrobial--Pro-Proliferative Peptide Conjugates by Kosikowska, Paulina, Pikula, Michal, Langa, Paulina, Trzonkowski, Piotr, Obuchowski, Michał, Lesner, Adam

“…Skin represents the largest organ of the human body and plays a crucial role in its protection from the negative impact of the outside environment, maintains…”
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Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery by Lesner, Adam, Łęgowska, Anna, Wysocka, Magdalena, Rolka, Krzysztof

“…This work is focused on SFTI-1, a member of the Bowman-Birk family of inhibitors. This 14 amino acid cyclic peptide exhibits several features i.e. compact…”
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Properties of the HtrA Protease From Bacterium Helicobacter pylori Whose Activity Is Indispensable for Growth Under Stress Conditions by Zarzecka, Urszula, Modrak-Wójcik, Anna, Figaj, Donata, Apanowicz, Malgorzata, Lesner, Adam, Bzowska, Agnieszka, Lipinska, Barbara, Zawilak-Pawlik, Anna, Backert, Steffen, Skorko-Glonek, Joanna

“…The protease high temperature requirement A from the gastric pathogen (HtrA ) belongs to the well conserved family of serine proteases. HtrA is an important…”
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Future of protease activity assays by Wysocka, Magdalena, Lesner, Adam

“…Proteolysis is doubtlessly the most widespread mechanism of biological regulation. By controlling protein synthesis, turnover and activity, it is involved in…”
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The Bactericidal Activity of Temporin Analogues Against Methicillin Resistant Staphylococcus aureus by Golda, Anna, Kosikowska-Adamus, Paulina, Kret, Aleksandra, Babyak, Olena, Wójcik, Kinga, Dobosz, Ewelina, Potempa, Jan, Lesner, Adam, Koziel, Joanna

“…is a major infectious agent responsible for a plethora of superficial skin infections and systemic diseases, including endocarditis and septic arthritis…”
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Novel Cell Permeable Polymers of N -Substituted L-2,3-Diaminopropionic Acid (DAPEGs) and Cellular Consequences of Their Interactions with Nucleic Acids by Romanowska, Anita, Węgrzyn, Katarzyna, Bury, Katarzyna, Sikorska, Emilia, Gnatek, Aleksandra, Piwkowska, Agnieszka, Konieczny, Igor, Lesner, Adam, Wysocka, Magdalena

“…The present study aimed to synthesize novel polycationic polymers composed of -substituted L-2,3-diaminopropionic acid residues (DAPEGs) and investigate their…”
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Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases by Hamon, Yveline, Legowska, Monika, Hervé, Virginie, Dallet-Choisy, Sandrine, Marchand-Adam, Sylvain, Vanderlynden, Lise, Demonte, Michèle, Williams, Rich, Scott, Christopher J., Si-Tahar, Mustapha, Heuzé-Vourc'h, Nathalie, Lalmanach, Gilles, Jenne, Dieter E., Lesner, Adam, Gauthier, Francis, Korkmaz, Brice

“…The cysteine protease cathepsin C (CatC) activates granule-associated proinflammatory serine proteases in hematopoietic precursor cells. Its early inhibition…”
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Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains by Glaza, Przemyslaw, Osipiuk, Jerzy, Wenta, Tomasz, Zurawa-Janicka, Dorota, Jarzab, Miroslaw, Lesner, Adam, Banecki, Bogdan, Skorko-Glonek, Joanna, Joachimiak, Andrzej, Lipinska, Barbara

“…Human HtrA3 protease, which induces mitochondria-mediated apoptosis, can be a tumor suppressor and a potential therapeutic target in the treatment of cancer…”
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Structural Determinants of Substrate Specificity of SplF Protease from Staphylococcus aureus by Stach, Natalia, Karim, Abdulkarim, Golik, Przemyslaw, Kitel, Radoslaw, Pustelny, Katarzyna, Gruba, Natalia, Groborz, Katarzyna, Jankowska, Urszula, Kedracka-Krok, Sylwia, Wladyka, Benedykt, Drag, Marcin, Lesner, Adam, Dubin, Grzegorz

“…Accumulating evidence suggests that six proteases encoded in the operon of a dangerous human pathogen, , may play a role in virulence. Interestingly, SplA, B,…”
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Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis by Lamort, Anne-Sophie, Hamon, Yveline, Czaplewski, Cezary, Gieldon, Artur, Seren, Seda, Coquet, Laurent, Lecaille, Fabien, Lesner, Adam, Lalmanach, Gilles, Gauthier, Francis, Jenne, Dieter, Korkmaz, Brice

“…Cysteine cathepsin C (CatC) is a ubiquitously expressed, lysosomal aminopeptidase involved in the activation of zymogens of immune-cell-associated serine…”
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Lipidation of Temporin-1CEb Derivatives as a Tool for Activity Improvement, Pros and Cons of the Approach by Kosikowska-Adamus, Paulina, Sikorska, Emilia, Wyrzykowski, Dariusz, Walewska, Aleksandra, Golda, Anna, Deptuła, Milena, Obuchowski, Michał, Prahl, Adam, Pikuła, Michał, Lesner, Adam

“…The alarming raise of multi-drug resistance among human microbial pathogens makes the development of novel therapeutics a priority task. In contrast to…”
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