Search Results - "Lesnefsky, Edward J"

Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies by Lesnefsky, Edward J, Chen, Qun, Tandler, Bernard, Hoppel, Charles L

“…Mitochondria have emerged as key participants in and regulators of myocardial injury during ischemia and reperfusion. This review examines the sites of damage…”
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Mitochondrial Metabolism in Aging Heart by Lesnefsky, Edward J, Chen, Qun, Hoppel, Charles L

“…Altered mitochondrial metabolism is the underlying basis for the increased sensitivity in the aged heart to stress. The aged heart exhibits impaired metabolic…”
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Leigh Syndrome: A Tale of Two Genomes by Bakare, Ajibola B, Lesnefsky, Edward J, Iyer, Shilpa

“…Leigh syndrome is a rare, complex, and incurable early onset (typically infant or early childhood) mitochondrial disorder with both phenotypic and genetic…”
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Mitochondrial Complex I Inhibition by Metformin Limits Reperfusion Injury by Mohsin, Ahmed A, Chen, Qun, Quan, Nanhu, Rousselle, Thomas, Maceyka, Michael W, Samidurai, Arun, Thompson, Jeremy, Hu, Ying, Li, Ji, Lesnefsky, Edward J

“…Transient, reversible blockade of complex I during early reperfusion after ischemia limits cardiac injury. We studied the cardioprotection of high dose of…”
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Ischemia and reperfusion injury to mitochondria and cardiac function in donation after circulatory death hearts- an experimental study by Akande, Oluwatoyin, Chen, Qun, Toldo, Stefano, Lesnefsky, Edward J, Quader, Mohammed

“…The ultimate treatment for patients with end-stage heart failure is heart transplantation. The number of donor hearts which are primarily procured from…”
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Activation of mitochondrial calpain and increased cardiac injury: beyond AIF release by Thompson, Jeremy, Hu, Ying, Lesnefsky, Edward J, Chen, Qun

“…Calpain 1 (CPN1) is a ubiquitous cysteine protease that exists in both cytosol and cardiac mitochondria. Mitochondrial CPN1 (mit-CPN1) is located in the…”
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A new strategy to decrease cardiac injury in aged heart following ischaemia-reperfusion: enhancement of the interaction between AMPK and SIRT1 by Chen, Qun, Lesnefsky, Edward J

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Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria by Chen, Qun, Moghaddas, Shadi, Hoppel, Charles L, Lesnefsky, Edward J

“…Cardiac ischemia decreases complex III activity, cytochrome c content, and respiration through cytochrome oxidase in subsarcolemmal mitochondria (SSM) and…”
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Calpain-mediated protein targets in cardiac mitochondria following ischemia–reperfusion by Li, Ling, Thompson, Jeremy, Hu, Ying, Lesnefsky, Edward J., Willard, Belinda, Chen, Qun

“…Calpain 1 and 2 (CPN1/2) are calcium-dependent cysteine proteases that exist in cytosol and mitochondria. Pharmacologic inhibition of CPN1/2 decreases cardiac…”
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Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species by Szczepanek, Karol, Chen, Qun, Derecka, Marta, Salloum, Fadi N., Zhang, Qifang, Szelag, Magdalena, Cichy, Joanna, Kukreja, Rakesh C., Dulak, Jozef, Lesnefsky, Edward J., Larner, Andrew C.

“…Expression of the STAT3 transcription factor in the heart is cardioprotective and decreases the levels of reactive oxygen species. Recent studies indicate that…”
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Inhibition of Bcl-2 sensitizes mitochondrial permeability transition pore (MPTP) opening in ischemia-damaged mitochondria by Chen, Qun, Xu, Haishan, Xu, Aijun, Ross, Thomas, Bowler, Elizabeth, Hu, Ying, Lesnefsky, Edward J

“…Mitochondria are critical to cardiac injury during reperfusion as a result of damage sustained during ischemia, including the loss of bcl-2. We asked if bcl-2…”
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Function of Mitochondrial Stat3 in Cellular Respiration by Wegrzyn, Joanna, Potla, Ramesh, Chwae, Yong-Joon, Sepuri, Naresh B.V, Zhang, Qifang, Koeck, Thomas, Derecka, Marta, Szczepanek, Karol, Szelag, Magdalena, Gornicka, Agnieszka, Moh, Akira, Moghaddas, Shadi, Chen, Qun, Bobbili, Santha, Cichy, Joanna, Dulak, Jozef, Baker, Darren P, Wolfman, Alan, Stuehr, Dennis, Hassan, Medhat O, Fu, Xin-Yuan, Avadhani, Narayan, Drake, Jennifer I, Fawcett, Paul, Lesnefsky, Edward J, Larner, Andrew C

“…Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes. We provide evidence…”
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Potential therapeutic benefits of strategies directed to mitochondria by Camara, Amadou K S, Lesnefsky, Edward J, Stowe, David F

“…The mitochondrion is the most important organelle in determining continued cell survival and cell death. Mitochondrial dysfunction leads to many human…”
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Insulin dysregulation drives mitochondrial cholesterol metabolite accumulation: initiating hepatic toxicity in nonalcoholic fatty liver disease by Minowa, Kei, Rodriguez-Agudo, Daniel, Suzuki, Mitsuyoshi, Muto, Yamato, Hirai, Saeko, Wang, Yaping, Su, Lianyong, Zhou, Huiping, Chen, Qun, Lesnefsky, Edward J., Mitamura, Kuniko, Ikegawa, Shigeo, Takei, Hajime, Nittono, Hiroshi, Fuchs, Michael, Pandak, William M., Kakiyama, Genta

“…CYP7B1 catalyzes mitochondria-derived cholesterol metabolites such as (25R)26-hydroxycholesterol (26HC) and 3β-hydroxy-5-cholesten-(25R)26-oic acid (3βHCA) and…”
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Reversible blockade of electron transport during ischemia protects mitochondria and decreases myocardial injury following reperfusion by Chen, Qun, Moghaddas, Shadi, Hoppel, Charles L, Lesnefsky, Edward J

“…Cardiac mitochondria sustain damage during ischemia and reperfusion, contributing to cell death. The reversible blockade of electron transport during ischemia…”
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Assessment of mitochondrial respiratory capacity using minimally invasive and noninvasive techniques in persons with spinal cord injury by Lai, Raymond E, Holman, Matthew E, Chen, Qun, Rivers, Jeannie, Lesnefsky, Edward J, Gorgey, Ashraf S

“…Muscle biopsies are the gold standard to assess mitochondrial respiration; however, biopsies are not always a feasible approach in persons with spinal cord…”
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Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension by Gomez-Arroyo, Jose, Mizuno, Shiro, Szczepanek, Karol, Van Tassell, Benjamin, Natarajan, Ramesh, dos Remedios, Cristobal G, Drake, Jennifer I, Farkas, Laszlo, Kraskauskas, Donatas, Wijesinghe, Dayanjan S, Chalfant, Charles E, Bigbee, John, Abbate, Antonio, Lesnefsky, Edward J, Bogaard, Harm J, Voelkel, Norbert F

“…Right ventricular (RV) dysfunction (RVD) is the most frequent cause of death in patients with pulmonary arterial hypertension. Although abnormal energy…”
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Evaluating the Bioenergetics Health Index Ratio in Leigh Syndrome Fibroblasts to Understand Disease Severity by Bakare, Ajibola B, Dean, Joseph, Chen, Qun, Thorat, Vedant, Huang, Yimin, LaFramboise, Thomas, Lesnefsky, Edward J, Iyer, Shilpa

“…Several pediatric mitochondrial disorders, including Leigh syndrome (LS), impact mitochondrial (mt) genetics, development, and metabolism, leading to complex…”
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Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion by Chen, Qun, Camara, Amadou K S, Stowe, David F, Hoppel, Charles L, Lesnefsky, Edward J

“…Mitochondria are increasingly recognized as lynchpins in the evolution of cardiac injury during ischemia and reperfusion. This review addresses the emerging…”
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Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential by Meshrkey, Fibi, Scheulin, Kelly M, Littlejohn, Christopher M, Stabach, Joshua, Saikia, Bibhuti, Thorat, Vedant, Huang, Yimin, LaFramboise, Thomas, Lesnefsky, Edward J, Rao, Raj R, West, Franklin D, Iyer, Shilpa

“…Human mitochondrial DNA mutations are associated with common to rare mitochondrial disorders, which are multisystemic with complex clinical pathologies. The…”
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