Search Results - "Lesnefsky, E."

Anakinra improves exercise peak aerobic capacity in patients with recently decompensated systolic heart failure by Van Tassell, B.W., Viscusi, M.M., Del Buono, M.G., Canada, J., Carbone, S., Trankle, C., Buckley, L., Lesnefsky, E., Arena, R., Abbate, A.

“…Objective: To evaluate the effects of anakinra on aerobic exercise capacity in patients with recently decompensated systolic HF and systemic inflammation…”
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Myocardial ischemia decreases oxidative phosphorylation through cytochrome oxidase in subsarcolemmal mitochondria by Lesnefsky, E J, Tandler, B, Ye, J, Slabe, T J, Turkaly, J, Hoppel, C L

“…The effect of myocardial ischemia on mitochondrial oxidative phosphorylation was investigated using isolated, buffer-perfused rabbit hearts. After 45 min of…”
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Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure by Lesnefsky, Edward J., Moghaddas, Shadi, Tandler, Bernard, Kerner, Janos, Hoppel, Charles L.

“…Mitochondria contribute to cardiac dysfunction and myocyte injury via a loss of metabolic capacity and by the production and release of toxic products. This…”
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Intracoronary ultrasound imaging: Correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty by Hodgson, John McB, Reddy, Karan G., Suneja, Randeep, Nair, Ravi N., Lesnefsky, Edward J., Sheehan, Helen M.

“…Objectives. This study was designed to establish the relation between ultrasound-derived atheroma morphology and the clinical, procedural and angiographie…”
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Aging Selectively Decreases Oxidative Capacity in Rat Heart Interfibrillar Mitochondria by Fannin, Stephen W., Lesnefsky, Edward J., Slabe, Thomas J., Hassan, Mehat O., Hoppel, Charles L.

“…Mitochondrial-derived oxidative injury contributes to cellular aging as well as to reperfusion-induced tissue damage. While the aging-heart suffers greater…”
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Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria by Lesnefsky, E J, Slabe, T J, Stoll, M S, Minkler, P E, Hoppel, C L

“…Mitochondria contribute to myocyte injury during ischemia. After 30 and 45 min of ischemia in the isolated perfused rabbit heart, subsarcolemmal mitochondria…”
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Tissue iron overload and mechanisms of iron-catalyzed oxidative injury by Lesnefsky, E J

“…Tissue iron overload causes clinical syndromes that involve the heart, liver, and pancreas. While tissue iron uptake occurs by both transferrin-dependent and…”
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Exogenous intracellular, but not extracellular, iron augments myocardial reperfusion injury by Lesnefsky, E J, Ye, J

“…Although previous studies using iron chelators suggest that iron-catalyzed reactions exacerbate myocardial injury, a direct demonstration of the timing, sites,…”
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Increased left ventricular dysfunction in elderly patients despite successful thrombolysis: The GUSTO-I angiographic experience by Lesnefsky, Edward J., Lundergan, Conor F., Hodgson, John McB, Nair, Ravi, Reiner, Jonathan S., Greenhouse, Samuel W., Califf, Robert M., Ross, Allan M.

“…This study sought to determine whether the recovery of regional and global left ventricular function is reduced in elderly patients despite successful…”
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Ischemic Injury to Mitochondrial Electron Transport in the Aging Heart: Damage to the Iron–Sulfur Protein Subunit of Electron Transport Complex III by Lesnefsky, Edward J., Gudz, Tatyana I., Migita, Catharina T., Ikeda-Saito, Masao, Hassan, Medhat O., Turkaly, Peter J., Hoppel, Charles L.

“…The aging heart sustains greater injury during ischemia and reperfusion compared to adult hearts. Aging decreases oxidative function in interfibrillar…”
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Aging Decreases Electron Transport Complex III Activity in Heart Interfibrillar Mitochondria by Alteration of the Cytochrome c Binding Site by Lesnefsky, Edward J., Gudz, Tatyana I., Moghaddas, Shadi, Migita, Catharina T., Ikeda-Saito, Masao, Turkaly, Peter J., Hoppel, Charles L.

“…Aging alters cardiac physiology and structure and enhances damage during ischemia and reperfusion. Aging selectively decreases the rate of oxidative…”
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Separation and Quantitation of Phospholipids and Lysophospholipids by High-Performance Liquid Chromatography by Lesnefsky, Edward J., Stoll, Maria S.K., Minkler, Paul E., Hoppel, Charles L.

“…We describe a comprehensive approach to the separation, quantitation, and characterization of phospholipids and lysophospholipids present in complex biological…”
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Role of Leukocytes in Coronary Vascular Endothelial Injury Due to Ischemia and Reperfusion by Sheridan, Frank M, Dauber, Ira M, McMurtry, Ivan F, Lesnefsky, Edward J, Horwitz, Lawrence D

“…A possible cause of the coronary endothelial injury that occurs with ischemia and reperfusion is the local accumulation of leukocytes during these events. To…”
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Functional Coronary Microvascular Injury Evident As Increased Permeability Due to Brief Ischemia and Reperfusion by Dauber, Ira M, VanBenthuysen, Karyl M, McMurtry, Ivan F, Wheeler, Gretchen S, Lesnefsky, Edward J, Horwitz, Lawrence D, Weil, John V

“…Although morphological studies suggest that coronary vascular injury is a result of prolonged ischemia and subsequent reperfusion, whether functional coronary…”
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Preservation of cardiolipin content during aging in rat heart interfibrillar mitochondria by Moghaddas, Shadi, Stoll, Maria S K, Minkler, Paul E, Salomon, Robert G, Hoppel, Charles L, Lesnefsky, Edward J

“…Aging selectively decreases the rate of oxidative phosphorylation in the interfibrillar population of cardiac mitochondria (IFM) located between the myofibers…”
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Myocardial Sulfhydryl Pool Alterations Occur During Reperfusion After Brief and Prolonged Myocardial Ischemia In Vivo by Lesnefsky, Edward J, Dauber, Ira M, Horwitz, Lawrence D

“…Myocardial sulfhydryl (SH)-containing compounds, including reduced glutathione (GSH), are both defenses against and potential markers of reactive oxygen…”
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Reduction of infarct size by cell-permeable oxygen metabolite scavengers by Lesnefsky, E J

“…The timely restoration of blood flow to severely ischemic myocardium limits myocardial infarct size. However, experimental studies demonstrate that the…”
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Deferoxamine pretreatment reduces canine infarct size and oxidative injury by Lesnefsky, E J, Repine, J E, Horwitz, L D

“…To test whether iron-catalyzed processes contribute to myocardial necrosis during ischemia and reperfusion, we administered the iron chelator, deferoxamine, to…”
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Prevention of lipid peroxidation does not prevent oxidant-induced myocardial contractile dysfunction by Kong, Y, Lesnefsky, E J, Ye, J, Horwitz, L D

“…We tested whether, with exposure to an extraneous iron-catalyzed free radical-generating system, prevention of lipid peroxidation with U74006F, a…”
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Existence and participation of xanthine oxidase in reperfusion injury of ischemic rabbit myocardium by Terada, L S, Rubinstein, J D, Lesnefsky, E J, Horwitz, L D, Leff, J A, Repine, J E

“…Using a highly specific assay that minimizes enzyme inactivation in vitro, we found that rabbit myocardial tissue contained low levels of xanthine oxidase (XO)…”
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