Tick-borne encephalitis (TBE) vaccination: Applying the most suitable vaccination schedule

Abstract Tick-borne encephalitis (TBE) is caused by an arthropod-borne virus, belonging to the family of Flaviviridae. In case of disease, which can lead to neurological sequelae or even fatal outcomes, only symptomatic treatment is available. TBE can be prevented by vaccination. Various primary imm...

Full description

Saved in:

Bibliographic Details
Published in:	Vaccine Vol. 25; no. 8; pp. 1470 - 1475
Main Authors:	Schöndorf, I, Beran, J, Cizkova, D, Lesna, V, Banzhoff, A, Zent, O
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 09-02-2007 Elsevier Elsevier Limited
Subjects:	Adolescent Adult Allergy and Immunology Applied microbiology Arachnids Arboviral encephalitis Arboviroses Biological and medical sciences Child Demographics Encephalitis Viruses, Tick-Borne - immunology Encephalitis, Tick-Borne - immunology Encephalitis, Tick-Borne - prevention & control Female Flaviviridae Flavivirus Fundamental and applied biological sciences. Psychology Human viral diseases Humans Immune response Immunization Immunization Schedule Infectious diseases Male Medical research Medical sciences Microbiology Middle Aged Neutralization Population Primary vaccination Schedules TBE Tick-borne encephalitis Tropical viral diseases Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral diseases Viral Vaccines - administration & dosage Viral Vaccines - adverse effects Viral Vaccines - immunology Schedules Tick-borne encephalitis TBE Primary vaccination Nervous system diseases Tick borne encephalitis Vaccination Vaccination schedule Cerebral disorder Infection Viral disease Arbovirus disease Central nervous system disease
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Abstract Tick-borne encephalitis (TBE) is caused by an arthropod-borne virus, belonging to the family of Flaviviridae. In case of disease, which can lead to neurological sequelae or even fatal outcomes, only symptomatic treatment is available. TBE can be prevented by vaccination. Various primary immunization schedules have been developed. To identify the most suitable schedule, the present randomised, controlled study was designed to provide data on the immune response elicited by four different immunization schedules obtained by ELISA and by neutralization test (NT). A total of 398 healthy subjects aged ≥12 years were randomised to vaccination according to either the rapid schedule (Group R, vaccination on days 0, 7 and 21), the conventional schedule (Group C, vaccination on days 0, 28 and 300), the modified conventional schedule (Group M, vaccination on days 0, 21 and 300) or the accelerated conventional schedule (Group A, vaccination on days 0, 14 and 300). Within 3 weeks (i.e. by day 21) antibody levels were higher in Group R and Group A than in Group M and Group C. Group R and Group C both had higher titres on days 42, 180 and 300, than Group A and Group M. The rapid schedule thus combines the advantages of fast protection and of high titres over the observation period of 300 days.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 ObjectType-News-3
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2006.10.028