Search Results - "Leslie, Theresa K."

Inhibitory Effect of Eslicarbazepine Acetate and S-Licarbazepine on Nav1.5 Channels by Leslie, Theresa K., Brückner, Lotte, Chawla, Sangeeta, Brackenbury, William J.

“…Eslicarbazepine acetate (ESL) is a dibenzazepine anticonvulsant approved as adjunctive treatment for partial-onset epileptic seizures. Following first pass…”
Get full text

Sodium channels and the ionic microenvironment of breast tumours by Leslie, Theresa K., Brackenbury, William J.

“…Cancers of epithelial origin such as breast, prostate, cervical, gastric, colon and lung cancer account for a large proportion of deaths worldwide. Better…”
Get full text

Sodium homeostasis in the tumour microenvironment by Leslie, Theresa K., James, Andrew D., Zaccagna, Fulvio, Grist, James T., Deen, Surrin, Kennerley, Aneurin, Riemer, Frank, Kaggie, Joshua D., Gallagher, Ferdia A., Gilbert, Fiona J., Brackenbury, William J.

“…The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at the cellular, tissue and patient levels. At the cellular level, the…”
Get full text

Sodium accumulation in breast cancer predicts malignancy and treatment response by James, Andrew D., Leslie, Theresa K., Kaggie, Joshua D., Wiggins, Laura, Patten, Lewis, Murphy O’Duinn, John, Langer, Swen, Labarthe, Marie-Christine, Riemer, Frank, Baxter, Gabrielle, McLean, Mary A., Gilbert, Fiona J., Kennerley, Aneurin J., Brackenbury, William J.

“…Background Breast cancer remains a leading cause of death in women and novel imaging biomarkers are urgently required. Here, we demonstrate the diagnostic and…”
Get full text

A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis by Leslie, Theresa K., Tripp, Aurelien, James, Andrew D., Fraser, Scott P., Nelson, Michaela, Sajjaboontawee, Nattanan, Capatina, Alina L., Toss, Michael, Fadhil, Wakkas, Salvage, Samantha C., Garcia, Mar Arias, Beykou, Melina, Rakha, Emad, Speirs, Valerie, Bakal, Chris, Poulogiannis, George, Djamgoz, Mustafa B. A., Jackson, Antony P., Matthews, Hugh R., Huang, Christopher L-H, Holding, Andrew N., Chawla, Sangeeta, Brackenbury, William J.

“…Solid tumours have abnormally high intracellular [Na + ]. The activity of various Na + channels may underlie this Na + accumulation. Voltage-gated Na +…”
Get full text

Inhibitory Effect of Eslicarbazepine Acetate and S-Licarbazepine on Na v 1.5 Channels by Leslie, Theresa K, Brückner, Lotte, Chawla, Sangeeta, Brackenbury, William J

“…Eslicarbazepine acetate (ESL) is a dibenzazepine anticonvulsant approved as adjunctive treatment for partial-onset epileptic seizures. Following first pass…”
Get full text

A novel Na v 1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis by Leslie, Theresa K, Tripp, Aurelien, James, Andrew D, Fraser, Scott P, Nelson, Michaela, Sajjaboontawee, Nattanan, Capatina, Alina L, Toss, Michael, Fadhil, Wakkas, Salvage, Samantha C, Garcia, Mar Arias, Beykou, Melina, Rakha, Emad, Speirs, Valerie, Bakal, Chris, Poulogiannis, George, Djamgoz, Mustafa B A, Jackson, Antony P, Matthews, Hugh R, Huang, Christopher L-H, Holding, Andrew N, Chawla, Sangeeta, Brackenbury, William J

“…Solid tumours have abnormally high intracellular [Na ]. The activity of various Na channels may underlie this Na accumulation. Voltage-gated Na channels…”
Get full text