Search Results - "Leslie, Elaine"

Arsenic–glutathione conjugate transport by the human multidrug resistance proteins (MRPs/ABCCs) by Leslie, Elaine M.

“…Millions of people world-wide are chronically exposed to inorganic forms of the environmental toxicant arsenic in drinking water. This has led to a public…”
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Glutathione transferase P1 is modified by palmitate by Marensi, Vanessa, Yap, Megan C, Ji, Yuhuan, Lin, Cheng, Berthiaume, Luc G, Leslie, Elaine M

“…Glutathione transferase P1 (GSTP1) is a multi-functional protein that protects cells from electrophiles by catalyzing their conjugation with glutathione, and…”
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Cellular arsenic transport pathways in mammals by Roggenbeck, Barbara A., Banerjee, Mayukh, Leslie, Elaine M.

“…Natural contamination of drinking water with arsenic results in the exposure of millions of people world-wide to unacceptable levels of this metalloid. This is…”
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Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense by Leslie, Elaine M., Deeley, Roger G., Cole, Susan P.C.

“…In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease in cellular drug accumulation which is attributed to the…”
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Biliary excretion of arsenic by human HepaRG cells is stimulated by selenide and mediated by the multidrug resistance protein 2 (MRP2/ABCC2) by Zhou, Janet R., Kaur, Gurnit, Ma, Yingze, Arutyunov, Denis, Lu, Xiufen, Le, X. Chris, Leslie, Elaine M.

“…[Display omitted] Millions of people worldwide are exposed to unacceptable levels of arsenic, a proven human carcinogen, in drinking water. In animal models,…”
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Biochemical characterization of two novel mutations in the human high-affinity choline transporter 1 identified in a patient with congenital myasthenic syndrome by Rizvi, Midhat, Truong, Tina K, Zhou, Janet, Batta, Manav, Moran, Ellen S, Pappas, John, Chu, Mary Lynn, Caluseriu, Oana, Evrony, Gilad D, Leslie, Elaine M, Cordat, Emmanuelle

“…Abstract Congenital myasthenic syndrome (CMS) is a heterogeneous condition associated with 34 different genes, including SLC5A7, which encodes the…”
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Accumulation and Transport of Roxarsone, Arsenobetaine, and Inorganic Arsenic Using the Human Immortalized Caco‑2 Cell Line by Liu, Qingqing, Leslie, Elaine M, Le, X. Chris

“…Roxarsone (Rox), an organoarsenic compound, served as a feed additive in the poultry industry for more than 60 years. Residual amounts of Rox present in…”
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Fitting the US National Park Service for Change by SCHWARTZ, MARK W., REDFORD, KENT H., LESLIE, ELAINE F.

“…The US National Park Service (NPS), which manages over 85 million acres and over 400 units, contends with myriad external drivers of ecosystem change that…”
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Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites by Whitlock, Brayden D, Ma, Yingze, Conseil, Gwenaelle, O'Brien, Alicia R, Banerjee, Mayukh, Swanlund, Diane P, Lin, Z Ping, Wang, Yao, Le, X Chris, Schuetz, John D, Cole, Susan P C, Leslie, Elaine M

“…Millions of people globally are exposed to the proven human carcinogen arsenic at unacceptable levels in drinking water. In contrast, arsenic is a poor rodent…”
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Polymorphic variants of MRP4/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions by Banerjee, Mayukh, Marensi, Vanessa, Conseil, Gwenaëlle, Le, X. Chris, Cole, Susan P.C., Leslie, Elaine M.

“…[Display omitted] Broad inter-individual variation exists in susceptibility to arsenic-induced tumours, likely involving differences in the ability of…”
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Comparative Toxicity of Arsenic Metabolites in Human Bladder Cancer EJ-1 Cells by Naranmandura, Hua, Carew, Michael W, Xu, Shi, Lee, Jane, Leslie, Elaine M, Weinfeld, Michael, Le, X. Chris

“…The human bladder is one of the primary target organs for arsenic-induced carcinogenicity, and arsenic metabolites in urine have been suspected to be directly…”
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The novel p.Ser263Phe mutation in the human high‐affinity choline transporter 1 (CHT1/SLC5A7) causes a lethal form of fetal akinesia syndrome by Banerjee, Mayukh, Arutyunov, Denis, Brandwein, Daniel, Janetzki‐Flatt, Cassandra, Kolski, Hanna, Hume, Stacey, Leonard, Norma Jean, Watt, James, Lacson, Atilano, Baradi, Monica, Leslie, Elaine M., Cordat, Emmanuelle, Caluseriu, Oana

“…A subset of a larger and heterogeneous class of disorders, the congenital myasthenic syndromes (CMS) are caused by pathogenic variants in genes encoding…”
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Transporters and Toxicity: Insights From the International Transporter Consortium Workshop 4 by Hafey, Michael J., Aleksunes, Lauren M., Bridges, Christy C., Brouwer, Kenneth R., Chien, Huan‐Chieh, Leslie, Elaine M., Hu, Shuiying, Li, Yang, Shen, Jinshan, Sparreboom, Alex, Sprowl, Jason, Tweedie, Donald, Lai, Yurong

“…Over the last decade, significant progress been made in elucidating the role of membrane transporters in altering drug disposition, with important…”
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Multidrug Resistance Protein 4 (MRP4/ABCC4) Protects Cells from the Toxic Effects of Halobenzoquinones by Li, Jinhua, Bauer, Madlen, Moe, Birget, Leslie, Elaine M, Li, Xing-Fang

“…Halobenzoquinones (HBQs) are frequently detected disinfection byproducts (DBPs) in treated water. Recent studies have demonstrated that HBQs are highly…”
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Animal models of postpartum hemorrhage by Hargett, Sarah E., Leslie, Elaine F., Chapa, Hector O., Gaharwar, Akhilesh K.

“…Postpartum hemorrhage (PPH)—heavy bleeding following childbirth—is a leading cause of morbidity and mortality worldwide. PPH can affect individuals regardless…”
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Metabolism of a Phenylarsenical in Human Hepatic Cells and Identification of a New Arsenic Metabolite by Liu, Qingqing, Leslie, Elaine M, Moe, Birget, Zhang, Hongquan, Douglas, Donna N, Kneteman, Norman M, Le, X. Chris

“…Environmental contamination and human consumption of chickens could result in potential exposure to Roxarsone (3-nitro-4-hydroxyphenylarsonic acid), an organic…”
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Detection of Ophthalmic Acid in Serum from Acetaminophen-Induced Acute Liver Failure Patients Is More Frequent in Non-Survivors by Kaur, Gurnit, Leslie, Elaine M, Tillman, Holly, Lee, William M, Swanlund, Diane P, Karvellas, Constantine J

“…Acetaminophen (APAP) hepatotoxicity is related to the formation of N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified through conjugation with reduced…”
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Human red blood cell uptake and sequestration of arsenite and selenite: Evidence of seleno-bis(S-glutathionyl) arsinium ion formation in human cells by Kaur, Gurnit, Javed, Warda, Ponomarenko, Olena, Shekh, Kamran, Swanlund, Diane P., Zhou, Janet R., Summers, Kelly L., Casini, Angela, Wenzel, Margot N., Casey, Joseph R., Cordat, Emmanuelle, Pickering, Ingrid J., George, Graham N., Leslie, Elaine M.

“…[Display omitted] Over 200 million people worldwide are exposed to the human carcinogen, arsenic, in contaminated drinking water. In laboratory animals,…”
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A novel pathway for arsenic elimination: human multidrug resistance protein 4 (MRP4/ABCC4) mediates cellular export of dimethylarsinic acid (DMAV) and the diglutathione conjugate of monomethylarsonous acid (MMAIII) by Banerjee, Mayukh, Carew, Michael W, Roggenbeck, Barbara A, Whitlock, Brayden D, Naranmandura, Hua, Le, X Chris, Leslie, Elaine M

“…Hundreds of millions of people worldwide are exposed to unacceptable levels of arsenic in drinking water. This is a public health crisis because arsenic is a…”
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Absolute quantitation of acetaminophen‐modified human serum albumin in acute liver failure patients by liquid chromatography/tandem mass spectrometry by Geib, Timon, LeBlanc, André, Shiao, Tze Chieh, Roy, René, Leslie, Elaine M., Karvellas, Constantine J., Sleno, Lekha

“…Rationale Acetaminophen (APAP) is a well‐known analgesic, deemed a very safe over‐the‐counter medication. However, it is also the main cause of acute liver…”
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