Search Results - "Leslie, Alasdair J"

Structure and Interactions of the Human Programmed Cell Death 1 Receptor by Cheng, Xiaoxiao, Veverka, Vaclav, Radhakrishnan, Anand, Waters, Lorna C., Muskett, Frederick W., Morgan, Sara H., Huo, Jiandong, Yu, Chao, Evans, Edward J., Leslie, Alasdair J., Griffiths, Meryn, Stubberfield, Colin, Griffin, Robert, Henry, Alistair J., Jansson, Andreas, Ladbury, John E., Ikemizu, Shinji, Carr, Mark D., Davis, Simon J.

“…PD-1, a receptor expressed by T cells, B cells, and monocytes, is a potent regulator of immune responses and a promising therapeutic target. The structure and…”
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Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model by Ahmed, Mohamed, Tezera, Liku B, Herbert, Nicholas, Chambers, Mark, Reichmann, Michaela T, Nargan, Kievershen, Kloverpris, Henrik, Karim, Farina, Hlatshwayo, Mbali, Madensein, Rajhmun, Habesh, Munir, Hoque, Monjural, Steyn, Adrie J C, Elkington, Paul T, Leslie, Alasdair J

“…A robust immune response is required for resistance to pulmonary tuberculosis (TB), the primary disease caused by ( ). However, pharmaceutical inhibition of T…”
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HIV Control through a Single Nucleotide on the HLA-B Locus by Kløverpris, Henrik N, Harndahl, Mikkel, Leslie, Alasdair J, Carlson, Jonathan M, Ismail, Nasreen, van der Stok, Mary, Huang, Kuan-Hsiang Gary, Chen, Fabian, Riddell, Lynn, Steyn, Dewald, Goedhals, Dominique, van Vuuren, Cloete, Frater, John, Walker, Bruce D, Carrington, Mary, Ndung'u, Thumbi, Buus, Søren, Goulder, Philip

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Proliferative Capacity of Epitope-Specific CD8 T-Cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection by DAY, Cheryl L, KIEPIELA, Photini, WALKER, Bruce D, KLENERMAN, Paul, LESLIE, Alasdair J, VAN DER STOK, Mary, NAIR, Kriebashne, ISMAIL, Nasreen, HONEYBORNE, Isobella, CRAWFORD, Hayley, COOVADIA, Hoosen M, GOULDER, Philip J. R

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The paradox of immune checkpoint inhibition re-activating tuberculosis by Ahmed, Mohamed, Tezera, Liku B., Elkington, Paul T., Leslie, Alasdair J.

“…By attenuating T-cell activation, immune checkpoints (ICs) limit optimal anti-tumour responses and IC inhibition (ICI) has emerged as a new therapy for a broad…”
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HLA Footprints on Human Immunodeficiency Virus Type 1 Are Associated with Interclade Polymorphisms and Intraclade Phylogenetic Clustering by MATTHEWS, Philippa C, LESLIE, Alasdair J, HECKERMAN, David, NDUNG'U, Thumbi, WALKER, Bruce D, ALLEN, Todd M, PYBUS, Oliver G, GOULDER, Philip J. R, KATZOURAKIS, Aris, CRAWFORD, Hayley, PAYNE, Rebecca, PRENDERGAST, Andrew, POWER, Karen, KELLEHER, Anthony D, KLENERMAN, Paul, CARLSON, Jonathan

“…Author's Correction ( vol. 85 , p. 4635 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression by Brown, Julia A, Kiepiela, Photini, Reddy, Sharon, DePierres, Chantal, Coovadia, Hoosen M, Altfeld, Marcus, Kaufmann, Daniel E, Wherry, E. John, Moodley, Eshia S, Goulder, Philip J. R, Freeman, Gordon J, Mackey, Elizabeth W, Leslie, Alasdair J, Eichbaum, Quentin, Zhu, Baogong, Klenerman, Paul, Mncube, Zenele, Walker, Bruce D, Miller, Joseph D, Ahmed, Rafi, Day, Cheryl L, Duraiswamy, Jaikumar

“…Functional impairment of T cells is characteristic of many chronic mouse and human viral infections. The inhibitory receptor programmed death 1 (PD-1; also…”
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Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection by Draenert, Rika, Le Gall, Sylvie, Pfafferott, Katja J, Leslie, Alasdair J, Chetty, Polan, Brander, Christian, Holmes, Edward C, Chang, Shih-Chung, Feeney, Margaret E, Addo, Marylyn M, Ruiz, Lidia, Ramduth, Danni, Jeena, Prakash, Altfeld, Marcus, Thomas, Stephanie, Tang, Yanhua, Verrill, Cori L, Dixon, Catherine, Prado, Julia G, Kiepiela, Photini, Martinez-Picado, Javier, Walker, Bruce D, Goulder, Philip J R

“…Mutations within cytotoxic T lymphocyte (CTL) epitopes impair T cell recognition, but escape mutations arising in flanking regions that alter antigen…”
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HLA-A68: 02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective by Kløverpris, Henrik N, Stryhn, Anette, Harndahl, Mikkel, Carlson, Jonathan M, Leslie, Alasdair J, Chen, Fabian, Riddell, Lynn, Mulenga, Joseph, Walker, Bruce D, Ndung’u, Thumbi, Buus, Søren, Goulder, Philip

“…BACKGROUND:Human leukocyte allele (HLA) class I polymorphism has the greatest impact of human genetic variation on viral load set point. A substantial part of…”
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HIV escape and attenuation by cytotoxic T lymphocytes by Leslie, Alasdair J, Goulder, Philip JR

“…PURPOSE OF REVIEWMuch of the current HIV-1 vaccine research focuses on harnessing the cytotoxic T-lymphocyte arm of the immune response. However, HIV-1 appears…”
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The paradox of immune checkpoint inhibition reactivating tuberculosis by Ahmed, Mohamed, Tezera, Liku B, Elkington, Paul T, Leslie, Alasdair J

“…By attenuating T cell activation, immune checkpoints (ICs) limit optimal anti-tumor responses, and immune checkpoint inhibition (ICI) has emerged as a new…”
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Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA by Goulder, Philip J. R, Kiepiela, Photini, Leslie, Alasdair J, Honeyborne, Isobella, Ramduth, Danni, Thobakgale, Christina, Chetty, Senica, Rathnavalu, Prinisha, Moore, Corey, Pfafferott, Katja J, Hilton, Louise, Zimbwa, Peter, Moore, Sarah, Allen, Todd, Brander, Christian, Addo, Marylyn M, Altfeld, Marcus, James, Ian, Mallal, Simon, Bunce, Michael, Barber, Linda D, Szinger, James, Day, Cheryl, Klenerman, Paul, Mullins, James, Korber, Bette, Coovadia, Hoosen M, Walker, Bruce D

“…The extreme polymorphism in the human leukocyte antigen (HLA) class I region of the human genome is suggested to provide an advantage in pathogen defence…”
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HLA-A68:02-restricted Gag-specific CTL responses can drive selection pressure on HIV but are subdominant and ineffective by Kløverpris, Henrik N., Stryhn, Anette, Harndahl, Mikkel, Carlson, Jonathan M., Leslie, Alasdair J, Chen, Fabian, Riddell, Lynn, Mulenga, Joseph, Walker, Bruce D., Ndung’u, Thumbi, Buus, Søren, Goulder, Philip

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HLA Footprints on Human Immunodeficiency Virus Type 1 Are Associated with Interclade Polymorphisms and Intraclade Phylogenetic Clustering by Matthews, Philippa C., Leslie, Alasdair J., Katzourakis, Aris, Crawford, Hayley, Payne, Rebecca, Prendergast, Andrew, Power, Karen, Kelleher, Anthony D., Klenerman, Paul, Carlson, Jonathan, Heckerman, David, Ndung'u, Thumbi, Walker, Bruce D., Allen, Todd M., Pybus, Oliver G., Goulder, Philip J. R.

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