Search Results - "Leschinsky, Nicholas"

The Hypervariable Region of K-Ras4B Governs Molecular Recognition and Function by Abdelkarim, Hazem, Banerjee, Avik, Grudzien, Patrick, Leschinsky, Nicholas, Abushaer, Mahmoud, Gaponenko, Vadim

“…The flexible C-terminal hypervariable region distinguishes K-Ras4B, an important proto-oncogenic GTPase, from other Ras GTPases. This unique lysine-rich…”
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Conformational Dynamics Allows Sampling of an “Active-like” State by Oncogenic K-Ras-GDP by Grudzien, Patrick, Jang, Hyunbum, Leschinsky, Nicholas, Nussinov, Ruth, Gaponenko, Vadim

“…[Display omitted] •K-Ras-GDP can sample the “active-like” conformation found in the GTP-bound state.•Oncogenic mutations affect sampling of the “active-like”…”
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Engineered Allosteric Regulation of Protein Function by Fauser, Jordan, Leschinsky, Nicholas, Szynal, Barbara N., Karginov, Andrei V.

“…[Display omitted] •Bioengineered allostery provides a method for spatiotemporal regulation of proteins.•GPCR chimeras are used to dissect signaling of a…”
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The dynamic nature of the K-Ras/calmodulin complex can be altered by oncogenic mutations by Abdelkarim, Hazem, Leschinsky, Nicholas, Jang, Hyunbum, Banerjee, Avik, Nussinov, Ruth, Gaponenko, Vadim

“…Oncogenic mutant K-Ras promotes cancer cell proliferation, migration, invasion, and survival by assembling signaling complexes. To date, the functional and…”
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Enhancing ferryl accumulation in H2O2-dependent cytochrome P450s by Amaya, Jose A., Manley, Olivia M., Bian, Julia C., Rutland, Cooper D., Leschinsky, Nicholas, Ratigan, Steven C., Makris, Thomas M.

“…A facile strategy is presented to enhance the accumulation of ferryl (iron(IV)-oxo) species in H2O2 dependent cytochrome P450s (CYPs) of the CYP152 family. We…”
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A Distal Loop Controls Product Release and Chemo- and Regioselectivity in Cytochrome P450 Decarboxylases by Amaya, José A, Rutland, Cooper D, Leschinsky, Nicholas, Makris, Thomas M

“…Cytochrome P450 OleT utilizes hydrogen peroxide (H2O2) to catalyze the decarboxylation or hydroxylation of fatty acid (FA) substrates. Both reactions are…”
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Enhancing ferryl accumulation in H 2 O 2 -dependent cytochrome P450s by Amaya, Jose A, Manley, Olivia M, Bian, Julia C, Rutland, Cooper D, Leschinsky, Nicholas, Ratigan, Steven C, Makris, Thomas M

“…A facile strategy is presented to enhance the accumulation of ferryl (iron(IV)-oxo) species in H O dependent cytochrome P450s (CYPs) of the CYP152 family. We…”
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