Search Results - "Leschek, Ellen"

Iatrogenic Creutzfeldt-Jakob disease, final assessment by Brown, Paul, Brandel, Jean-Philippe, Sato, Takeshi, Nakamura, Yosikazu, MacKenzie, Jan, Will, Robert G, Ladogana, Anna, Pocchiari, Maurizio, Leschek, Ellen W, Schonberger, Lawrence B

“…The era of iatrogenic Creutzfeldt-Jakob disease (CJD) has nearly closed; only occasional cases with exceptionally long incubation periods are still appearing…”
Get full text

Plasma midkine concentrations in healthy children, children with increased and decreased adiposity, and children with short stature by Jee, Youn Hee, Lee, Kun Song, Yue, Shanna, Leschek, Ellen W, Boden, Matthew G, Jadra, Aysha, Klibanski, Anne, Vaidyanathan, Priya, Misra, Madhusmita, Chang, Young Pyo, Yanovski, Jack A, Baron, Jeffrey

“…Midkine (MDK), one of the heparin-binding growth factors, is highly expressed in multiple organs during embryogenesis. Plasma concentrations have been reported…”
Get full text

Psychiatric characterization of children with genetic causes of hyperandrogenism by Mueller, Sven C, Ng, Pamela, Sinaii, Ninet, Leschek, Ellen W, Green-Golan, Liza, VanRyzin, Carol, Ernst, Monique, Merke, Deborah P

“…ObjectiveVery little is known about the mental health status in children with genetic causes of hyperandrogenism. This study sought to characterize psychiatric…”
Get full text

DLG2 variants in patients with pubertal disorders by Jee, Youn Hee, Won, Sehoon, Lui, Julian C., Jennings, Melissa, Whalen, Philip, Yue, Shanna, Temnycky, Adrian G., Barnes, Kevin M., Cheetham, Tim, Boden, Matthew G., Radovick, Sally, Quinton, Richard, Leschek, Ellen W., Aguilera, Greti, Yanovski, Jack A., Seminara, Stephanie B., Crowley, William F., Delaney, Angela, Roche, Katherine W., Baron, Jeffrey

“…Purpose Impaired function of gonadotropin-releasing hormone (GnRH) neurons can cause a phenotypic spectrum ranging from delayed puberty to isolated…”
Get full text

Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study by Cali, Ignazio, Cohen, Mark L, Haik, Stephane, Parchi, Piero, Giaccone, Giorgio, Collins, Steven J, Kofskey, Diane, Wang, Han, McLean, Catriona A, Brandel, Jean-Philippe, Privat, Nicolas, Sazdovitch, Véronique, Duyckaerts, Charles, Kitamoto, Tetsuyuki, Belay, Ermias D, Maddox, Ryan A, Tagliavini, Fabrizio, Pocchiari, Maurizio, Leschek, Ellen, Appleby, Brian S, Safar, Jiri G, Schonberger, Lawrence B, Gambetti, Pierluigi

“…The presence of pathology related to the deposition of amyloid-β (Aβ) has been recently reported in iatrogenic Creutzfeldt-Jakob disease (iCJD) acquired from…”
Get full text

Suicides in National Hormone Pituitary Program Recipients of Cadaver-Derived Human Growth Hormone by Abrams, Joseph Y, Mills, James L, Schonberger, Lawrence B, Chang, David, Maddox, Ryan A, Belay, Ermias D, Leschek, Ellen W

“…Abstract Context Numerous reports of suicide among individuals who received cadaver-derived human growth hormone (c-hGH) through the National Hormone Pituitary…”
Get full text

Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone by Irwin, David J, Abrams, Joseph Y, Schonberger, Lawrence B, Leschek, Ellen Werber, Mills, James L, Lee, Virginia M-Y, Trojanowski, John Q

“…Growing evidence of cell-to-cell transmission of neurodegenerative disease (ND)-associated proteins (NDAPs) (ie, tau, Aβ, and α-synuclein) suggests possible…”
Get more information

Lower Risk of Creutzfeldt-Jakob Disease in Pituitary Growth Hormone Recipients Initiating Treatment after 1977 by Abrams, Joseph Y, Schonberger, Lawrence B, Belay, Ermias D, Maddox, Ryan A, Leschek, Ellen W, Mills, James L, Wysowski, Diane K, Fradkin, Judith E

“…Context: Creutzfeldt-Jakob disease (CJD) caused by contaminated cadaveric pituitary-derived human GH (hGH) has been responsible for hundreds of deaths…”
Get full text

Increased medial temporal lobe and striatal grey-matter volume in a rare disorder of androgen excess: a voxel-based morphometry (VBM) study by Mueller, Sven C., Merke, Deborah P., Leschek, Ellen W., Fromm, Steven, VanRyzin, Carol, Ernst, Monique

“…Major questions remain about how sex hormones influence human brain development and cognition. Studies in humans and animals suggest a strong impact of…”
Get full text

Early hyperandrogenism affects the development of hippocampal function: preliminary evidence from a functional magnetic resonance imaging study of boys with familial male precocious puberty by Mueller, Sven C, Mandell, Darcy, Leschek, Ellen W, Pine, Daniel S, Merke, Deborah P, Ernst, Monique

“…The way in which sex hormones influence cognitive and affective brain development is poorly understood. Despite increasing knowledge in the area of pediatric…”
Get more information

Quetiapine-Induced Central Hypothyroidism by Zenno, Anna, Leschek, Ellen

“…Hypothyroidism has been associated with quetiapine, but the underlying mechanism is not well understood and has been presumed to result from thyroid gland…”
Get full text

Does early growth hormone therapy prevent glucocorticoid-associated growth retardation in children with JIA? by Rider, Lisa G, Leschek, Ellen W

“…BACKGROUND Glucocorticoid therapy is associated with decreased growth; however, studies have shown that growth hormone (GH) treatment can restore growth in…”
Get full text

In Boys with Abnormal Developmental Tempo, Maturation of the Skeleton and the Hypothalamic-Pituitary-Gonadal Axis Remains Synchronous by Flor-Cisneros, Armando, Leschek, Ellen W., Merke, Deborah P., Barnes, Kevin M., Coco, Marilena, Cutler, Gordon B., Baron, Jeffrey

“…The primary mechanism that initiates puberty is unknown. One possible clue is that pubertal maturation often parallels skeletal maturation. Conditions that…”
Get full text

SUN-419 Quetiapine-Induced Central Hypothyroidism by Zenno, Anna, Leschek, Ellen

“…Background: Thyroid dysfunction has been associated with the use of quetiapine, but the underlying mechanism is not well understood. The scant data published…”
Get full text

Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp by Ehrmann, David A., Temple, Karla A., Rue, Abby, Barengolts, Elena, Mokhlesi, Babak, Van Cauter, Eve, Sam, Susan, Miller, M. Annette, Kahn, Steven E., Atkinson, Karen M., Palmer, Jerry P., Utzschneider, Kristina M., Gebremedhin, Tsige, Kernan-Schloss, Abigail, Kozedub, Alexandra, Montgomery, Brenda K., Morse, Emily J., Mather, Kieren J., Garrett, Tammy, Hannon, Tamara S., Lteif, Amale, Patel, Aniket, Chisholm, Robin, Moore, Karen, Pirics, Vivian, Pratt, Linda, Nadeau, Kristen J., Gross, Susan, Zeitler, Philip S., Williams, Jayne, Cree-Green, Melanie, Garcia Reyes, Yesenia, Vissat, Krista, Arslanian, Silva A., Brown, Kathleen, Guerra, Nancy, Porter, Kristin, Caprio, Sonia, Savoye, Mary, Pierpont, Bridget, Buchanan, Thomas A., Xiang, Anny H., Trigo, Enrique, Beale, Elizabeth, Hendee, Fadi N., Katkhouda, Namir, Nayak, Krishan, Martinez, Mayra, Montgomery, Cortney, Wang, Xinhui, Edelstein, Sharon L., Lachin, John M., Hogan, Ashley N., Marcovina, Santica, Harting, Jessica, Albers, John, Hill, Dave, Savage, Peter J., Leschek, Ellen W.

“…To compare insulin sensitivity (M/I) and β-cell responses in youth versus adults with impaired glucose tolerance (IGT) or drug-naïve, recently diagnosed type 2…”
Get full text

Insufficient evidence for an association between iatrogenic Alzheimer's disease and cadaveric pituitary‐derived growth hormone by Nath, Avi, Holtzman, David M., Miller, Bruce L., Grinberg, Lea T., Leschek, Ellen Werber

“…A Nature Medicine paper published in January 2024 describes eight cases of iatrogenic Alzheimer's disease in individuals who received cadaveric…”
Get full text

Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data by Haller, Michael J., Long, S. Alice, Blanchfield, J. Lori, Schatz, Desmond A., Skyler, Jay S., Krischer, Jeffrey P., Bundy, Brian N., Geyer, Susan M., Warnock, Megan V., Miller, Jessica L., Atkinson, Mark A., Becker, Dorothy J., Baidal, David A., DiMeglio, Linda A., Gitelman, Stephen E., Goland, Robin, Gottlieb, Peter A., Herold, Kevan C., Marks, Jennifer B., Moran, Antoinette, Rodriguez, Henry, Russell, William E., Wilson, Darrell M., Greenbaum, Carla J., Greenbaum, Carla J., Atkinson, Mark A., Baidal, David A., Battaglia, Manuela, Becker, Dorothy, Bingley, Penelope, Bosi, Emanuele, Buckner, Jane, Clements, Mark, Colman, Peter G., DiMeglio, Linda, Evans-Molina, Carmella, Gitelman, Stephen E., Goland, Robin, Gottlieb, Peter, Herold, Kevan, Knip, Mikael, Krischer, Jeffrey P., Lernmark, Ake, Moore, Wayne, Moran, Antoinette, Muir, Andrew, Palmer, Jerry, Peakman, Mark, Philipson, Louis, Raskin, Philip, Redondo, Maria, Rodriguez, Henry, Russell, William, Schatz, Desmond A., Sosenko, Jay M., Spain, Lisa, Wentworth, John, Wherrett, Diane, Wilson, Darrell M., Winter, William, Ziegler, Anette, Anderson, Mark, Antinozzi, Peter, Insel, Richard, Kay, Thomas, Marks, Jennifer B., Pugliese, Alberto, Roep, Bart, Skyler, Jay S., Toppari, Jorma, Leschek, Ellen, Bourcier, Katarzyna, Ridge, John, Rafkin, Lisa, Santiago, Irene, Bundy, Brian, Abbondondolo, Michael, Adams, Timothy, Asif, Ilma, Bjellquist, Jenna, Boonstra, Matthew, Burroughs, Cristina, Cleves, Mario, Cuthbertson, David, DeSalvatore, Meagan, Eberhard, Christopher, Fiske, Steve, Ford, Julie, Garmeson, Jennifer, Geyer, Susan, Hays, Brian, Henderson, Courtney, Henry, Martha, Heyman, Kathleen, Hsiao, Belinda, Karges, Christina, Koziol, Beata-Gabriela, Lane, Lindsay, Liu, Shu, Lloyd, Jennifer

“…A three-arm, randomized, double-masked, placebo-controlled phase 2b trial performed by the Type 1 Diabetes TrialNet Study Group previously demonstrated that…”
Get full text

Impact of Insulin and Metformin Versus Metformin Alone on β-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes by Nadeau, Kristen J., Hannon, Tamara S., Edelstein, Sharon L., Arslanian, Silva A., Caprio, Sonia, Leschek, Ellen W., Zeitler, Philip S., Buchanan, Thomas A., Ehrmann, David A., Mather, Kieren J., Kahn, Steven E., Gross, Susan, Williams, Jayne, Cree-Green, Melanie, Reyes, Yesenia Garcia, Vissat, Krista, Brown, Kathleen, Guerra, Nancy, Porter, Kristin, Savoye, Mary, Pierpont, Bridget, Garrett, Tammy, Lteif, Amale, Patel, Aniket, Chisholm, Robin, Moore, Karen, Pirics, Vivian, Pratt, Linda, Temple, Karla A., Rue, Abby, Barengolts, Elena, Mokhlesi, Babak, Van Cauter, Eve, Sam, Susan, Miller, M. Annette, Atkinson, Karen M., Palmer, Jerry P., Utzschneider, Kristina M., Gebremedhin, Tsige, Kernan-Schloss, Abigail, Kozedub, Alexandra, Montgomery, Brenda K., Morse, Emily J., Xiang, Anny H., Trigo, Enrique, Beale, Elizabeth, Hendee, Fadi N., Katkhouda, Namir, Nayak, Krishan, Martinez, Mayra, Montgomery, Cortney, Wang, Xinhui, Lachin, John M., Hogan, Ashley N., Marcovina, Santica, Harting, Jessica, Albers, John, Hill, Dave, Savage, Peter J.

“…Pediatric type 2 diabetes prevalence is increasing, with β-cell dysfunction key in its pathogenesis. The RISE Pediatric Medication Study compared two…”
Get full text

Effect of Oral Insulin on Prevention of Diabetes in Relatives of Patients With Type 1 Diabetes: A Randomized Clinical Trial by Krischer, Jeffrey P, Schatz, Desmond A, Bundy, Brian, Skyler, Jay S, Greenbaum, Carla J

“…IMPORTANCE: Type 1 diabetes requires major lifestyle changes and carries increased morbidity and mortality. Prevention or delay of diabetes would have major…”
Get full text

A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk by Redondo, Maria J, Geyer, Susan, Steck, Andrea K, Sharp, Seth, Wentworth, John M, Weedon, Michael N, Antinozzi, Peter, Sosenko, Jay, Atkinson, Mark, Pugliese, Alberto, Oram, Richard A

“…We tested the ability of a type 1 diabetes (T1D) genetic risk score (GRS) to predict progression of islet autoimmunity and T1D in at-risk individuals. We…”
Get full text