Search Results - "Lesche, R."

Super-enhancers define a proliferative PGC-1α-expressing melanoma subgroup sensitive to BET inhibition by Gelato, K A, Schöckel, L, Klingbeil, O, Rückert, T, Lesche, R, Toedling, J, Kalfon, E, Héroult, M, Lejeune, P, Mönning, U, Fernández-Montalván, A E, Bäurle, S, Siegel, S, Haendler, B

“…Metabolic changes are linked to epigenetic reprogramming and play important roles in several tumor types. PGC-1α is a transcriptional coactivator controlling…”
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Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the Pten Tumor Suppressor Gene in Vivo by Groszer, Matthias, Erickson, Rebecca, Scripture-Adams, Deirdre D., Lesche, Ralf, Trumpp, Andreas, Zack, Jerome A., Kornblum, Harley I., Liu, Xin, Wu, Hong

“…The mechanisms controlling neural stem cell proliferation are poorly understood. Here we demonstrate that the PTEN tumor suppressor plays an important role in…”
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S11.1 Stratification of systemic lupus erythematosus (SLE) patients based on the molecular patterns of mouse models by Rivas-Torrubia, M, Morell, M, Makowska, Z, Kageyama, J, Buttgereit, A, Cytometry Consortium, P, Lesche, R, Mcdonald, F, Alarcón-Riquelme, ME, Barturen-Briñas, G

“…PurposeSystemic lupus erythematosus (SLE) is an autoimmune, chronic and multisystemic autoimmune disorder, which typically affects women and presents high…”
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Experimental findings on customized mandibular implants in Göttingen minipigs – A pilot study by Markwardt, J, Sembdner, P, Lesche, R, Jung, R, Spekl, K, Mai, R, Schulz, M.C, Reitemeier, B

“…Abstract Reconstructing continuity defects of the mandible is still challenging for surgeons. The currently applied conventional titanium bridging plates have…”
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Super-enhancers define a proliferative PGC-1[alpha]-expressing melanoma subgroup sensitive to BET inhibition by Gelato, K A, Schöckel, L, Klingbeil, O, Rückert, T, Lesche, R, Toedling, J, Kalfon, E, Héroult, M, Lejeune, P, Mönning, U, Fernández-Montalván, A E, Bäurle, S, Siegel, S, Haendler, B

“…Metabolic changes are linked to epigenetic reprogramming and play important roles in several tumor types. PGC-1[alpha] is a transcriptional coactivator…”
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Live-Specific Deletion of Negative Regulator Pten Results in Fatty Liver and Insulin Hypersensitivity by Stiles, Bangyan, Wang, Ying, Stahl, Andreas, Bassilian, Sara, Lee, W. Paul, Kim, Yoon-Jung, Sherwin, Robert, Devaskar, Sherin, Lesche, Ralf, Magnuson, Mark A., Wu, Hong, Rosenfeld, Michael G.

“…In the liver, insulin controls both lipid and glucose metabolism through its cell surface receptor and intracellular mediators such as phosphatidylinositol…”
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PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms by Freeman, Daniel J., Li, Andrew G., Wei, Gang, Li, Heng-Hong, Kertesz, Nathalie, Lesche, Ralf, Whale, Andrew D., Martinez-Diaz, Hilda, Rozengurt, Nora, Cardiff, Robert D., Liu, Xuan, Wu, Hong

“…We show in this study that PTEN regulates p53 protein levels and transcriptional activity through both phosphatase-dependent and -independent mechanisms. The…”
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PTEN Modulates Cell Cycle Progression and Cell Survival by Regulating Phosphatidylinositol 3,4,5-Trisphosphate and Akt/Protein Kinase B Signaling Pathway by Sun, Hong, Lesche, Ralf, Li, Da-Ming, Liijental, Joanna, Zhang, Hui, Gao, Jing, Gavrilova, Nadia, Mueller, Brenda, Liu, Xin, Wu, Hong

“…To investigate the molecular basis of PTEN-mediated tumor suppression, we introduced a null mutation into the mouse Pten gene by homologous recombination in…”
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An elevated polyclonal free light chain level reflects a strong interferon signature in patients with systemic autoimmune diseases by Bettacchioli, Eléonore, Le Gaffric, Christelle, Mazeas, Margaux, Borghi, Maria Orietta, Frostegard, Johan, Barturen, Guillermo, Makowska, Zuzanna, Babei, Sepideh, Lesche, Ralf, Meroni, Pier Luigi, Alarcon-Riquelme, Marta E., Renaudineau, Yves

“…High amount of polyclonal free light chains (FLC) are reported in systemic autoimmune diseases (SAD) and we took advantage of the PRECISESADS study to better…”
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Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene by Lesche, Ralf, Groszer, Matthias, Gao, Jing, Wang, Ying, Messing, Albee, Sun, Hong, Liu, Xin, Wu, Hong

“…To overcome the early lethal phenotype in Pten super(-/-) mice and to study the role of PTEN in embryonic development, adult tissue function, and…”
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Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland by Li, Gang, Robinson, Gertraud W, Lesche, Ralf, Martinez-Diaz, Hilda, Jiang, Zhaorong, Rozengurt, Nora, Wagner, Kay-Uwe, Wu, De-Chang, Lane, Timothy F, Liu, Xin, Hennighausen, Lothar, Wu, Hong

“…PTEN tumor suppressor is frequently mutated in human cancers, including breast cancers. Female patients with inherited PTEN mutations suffer from virginal…”
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Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases by Liliental, J, Moon, S Y, Lesche, R, Mamillapalli, R, Li, D, Zheng, Y, Sun, H, Wu, H

“…Pten (Phosphatase and tensin homolog deleted on chromosome 10) is a recently identified tumor suppressor gene which is deleted or mutated in a variety of…”
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Tumour class prediction and discovery by microarray-based DNA methylation analysis by Adorján, Péter, Distler, Jürgen, Lipscher, Evelyne, Model, Fabian, Müller, Jürgen, Pelet, Cécile, Braun, Aron, Florl, Andrea R, Gütig, David, Grabs, Gabi, Howe, André, Kursar, Mischo, Lesche, Ralf, Leu, Erik, Lewin, André, Maier, Sabine, Müller, Volker, Otto, Thomas, Scholz, Christian, Schulz, Wolfgang A, Seifert, Hans-Helge, Schwope, Ina, Ziebarth, Heike, Berlin, Kurt, Piepenbrock, Christian, Olek, Alexander

“…Aberrant DNA methylation of CpG sites is among the earliest and most frequent alterations in cancer. Several studies suggest that aberrant methylation occurs…”
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Essential Role of AKT-1/Protein Kinase Bα in PTEN-Controlled Tumorigenesis by Stiles, Bangyan, Gilman, Valeriya, Khanzenzon, Natalya, Lesche, Ralf, Li, Annie, Qiao, Rong, Liu, Xin, Wu, Hong

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Quantitative DNA methylation profiling on a high-density oligonucleotide microarray by Fassbender, Anne, Lewin, Jörn, König, Thomas, Rujan, Tamas, Pelet, Cecile, Lesche, Ralf, Distler, Jürgen, Schuster, Matthias

“…Recently, the analysis and functional elucidation of CpG island methylation has become a focus area of genomic research. Deviations from the normal parental…”
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Transcriptome and Methylome Integrative Molecular Analysis Uncovers a New Systemic Autoimmune Disease Classification by Barturen, G, Babaei, S, Catala-Moll, F, Makowska, Z, Garcia-Gomez, A, Buttgereit, A, Carnero-Montoro, E, Hayat, S, Kerick, M, Charlon, T, Gemperline, DC, Le Lann, L, Quirantes-PIne, R, Borras-Linares, I, Muchmore, B, Kageyama, J, Rodriguez-Ubreva, J, Fernandez-Ochoa, A, Sanz, PC, Jamin, C, Lesche, R, Benschop, RJ, Chamberlain, C, Dow, ER, Gomes, T, Juarez, M, Laigle, L, Marovac, J, MacDonald, F, Wojcik, J, Ballestar, E, Beretta, L, Borghi, MO, Frostegard, J, Garcia, ML, Martin, J, Pers, JO, Renadineau, Y, Carretero, AS, Alarcon-Riquelme, M

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Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia by Osborn, Neal K, Zou, Hongzhi, Molina, Julian R, Lesche, Ralf, Lewin, Joern, Lofton-Day, Cathy, Klatt, Kristie K, Harrington, Jonathan J, Burgart, Lawrence J, Ahlquist, David A

“…This study explored the eyes absent 4 (EYA4) gene promoter methylation in noncolitic colorectal tissues and assessed its discrimination for neoplasia in…”
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DNA methylation marker and prediction of outcome in node-positive, estrogen-receptor positive breast cancer patients receiving adjuvant anthracyclin-based chemotherapy by Martens, J. W., Hartmann, O., Spyratos, F., Harbeck, N., Schmitt, M., Lerebours, F., Eppenberger-Castori, S., Vuaroqueaux, V., Foekens, J., Lesche, R.

“…Abstract only…”
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P76 - Cand1 in prostate cancer and its implication in therapy resistance to enzalutamide by Eigentler, A., Zwick, J., Tymoszuk, P., Schmitz, A.A., Pircher, A., Kocher, F., Schlicker, A., Lesche, R., Schäfer, G., Klocker, H., Heidegger, I.

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Cand1 in prostate cancer and its implication in therapy resistance to enzalutamide by Eigentler, A., Zwick, J., Tymoszuk, P., Schmitz, A.A., Pircher, A., Kocher, F., Schlicker, A., Lesche, R., Schäfer, G., Klocker, H., Heidegger, I.

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