Search Results - "Lesch, Michael"

Baseline severity and the prediction of placebo response in clinical trials for alcohol dependence: A meta‐regression analysis to develop an enrichment strategy by Scherrer, Bruno, Guiraud, Julien, Addolorato, Giovanni, Aubin, Henri‐Jean, Bejczy, Andrea, Benyamina, Amine, Brink, Wim, Caputo, Fabio, Dematteis, Maurice, Goudriaan, Anna E., Gual, Antoni, Kiefer, Falk, Leggio, Lorenzo, Lesch, Otto‐Michael, Maremmani, Icro, Nutt, David J., Paille, François, Perney, Pascal, Poulnais, Roch, Raffaillac, Quentin, Rehm, Jürgen, Rolland, Benjamin, Simon, Nicolas, Söderpalm, Bo, Sommer, Wolfgang H., Walter, Henriette, Spanagel, Rainer

“…Background There is considerable unexplained variability in alcohol abstinence rates (AR) in the placebo groups of randomized controlled trials (RCTs) for…”
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Efficacy and safety of sodium oxybate in alcohol‐dependent patients with a very high drinking risk level by Brink, Wim, Addolorato, Giovanni, Aubin, Henri‐Jean, Benyamina, Amine, Caputo, Fabio, Dematteis, Maurice, Gual, Antoni, Lesch, Otto‐Michael, Mann, Karl, Maremmani, Icro, Nutt, David, Paille, François, Perney, Pascal, Rehm, Jürgen, Reynaud, Michel, Simon, Nicolas, Söderpalm, Bo, Sommer, Wolfgang H., Walter, Henriette, Spanagel, Rainer

“…Medication development for alcohol relapse prevention or reduction of consumption is highly challenging due to methodological issues of pharmacotherapy trials…”
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Idiopathic Dilated Cardiomyopathy as a Late Complication of Healed Viral (Coxsackie B virus) Myocarditis: Historical Analysis, Review of the Lliterature, and a Postulated Unifying Hypothesis by Spotnitz, Michelle D., Lesch, Michael

“…A historically based literature review of the relationship between acute viral myocarditis and the subsequent development of a dilated cardiomyopathic state is…”
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In Memoriam: Edmund H. Sonnenblick by Michael, Lesch, MD

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Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes by MALTSEV, V. A, SABBAH, H. N, HIGGINS, R. S. D, SILVERMAN, N, LESCH, M, UNDROVINAS, A. I

“…Alterations in K+ channel expression and gating are thought to be the major cause of action potential remodeling in heart failure (HF). We previously reported…”
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Post-marketing and clinical safety experience with sodium oxybate for the treatment of alcohol withdrawal syndrome and maintenance of abstinence in alcohol-dependent subjects by Addolorato, Giovanni, Lesch, Otto-Michael, Maremmani, Icro, Walter, Henriette, Nava, Felice, Raffaillac, Quentin, Caputo, Fabio

“…: Sodium oxybate (SMO) has been approved in Italy and in Austria for the treatment of alcohol use disorder (AUD). This study describes the cumulative…”
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Cannabinoid Receptor 1 Blocker Rimonabant (SR 141 716) for Treatment of Alcohol Dependence : Results From a Placebo-Controlled, Double-Blind Trial by SOYKA, Michael, KOLLER, Gabriele, SCHMIDT, Peggy, LESCH, Otto-Michael, LEWEKE, Markus, FEHR, Christoph, GANN, Horst, MANN, Karl F

“…Multiple lines of evidence suggest that the endocannabinoid system is implicated in the development of alcohol dependence. In addition, in animal models, the…”
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Sodium oxybate for the maintenance of abstinence in alcohol-dependent patients: An international, multicenter, randomized, double-blind, placebo-controlled trial by Guiraud, Julien, Addolorato, Giovanni, Antonelli, Mariangela, Aubin, Henri-Jean, de Bejczy, Andrea, Benyamina, Amine, Cacciaglia, Roberto, Caputo, Fabio, Dematteis, Maurice, Ferrulli, Anna, Goudriaan, Anna E, Gual, Antoni, Lesch, Otto-Michael, Maremmani, Icro, Mirijello, Antonio, Nutt, David J, Paille, François, Perney, Pascal, Poulnais, Roch, Raffaillac, Quentin, Rehm, Jürgen, Rolland, Benjamin, Rotondo, Claudia, Scherrer, Bruno, Simon, Nicolas, Skala, Katrin, Söderpalm, Bo, Somaini, Lorenzo, Sommer, Wolfgang H, Spanagel, Rainer, Vassallo, Gabriele A, Walter, Henriette, van den Brink, Wim

“…Background: Sodium oxybate (SMO) has been shown to be effective in the maintenance of abstinence (MoA) in alcohol-dependent patients in a series of small…”
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Sodium Oxybate for Alcohol Dependence: A Network Meta-Regression Analysis Considering Population Severity at Baseline and Treatment Duration by Guiraud, Julien, Addolorato, Giovanni, Aubin, Henri-Jean, Bachelot, Sylvie, Batel, Philippe, de Bejczy, Andrea, Benyamina, Amine, Caputo, Fabio, Couderc, Monique, Dematteis, Maurice, Goudriaan, Anna E, Gual, Antoni, Lecoustey, Sylvie, Lesch, Otto-Michael, Maremmani, Icro, Nutt, David J, Paille, François, Perney, Pascal, Rehm, Jürgen, Rolland, Benjamin, Scherrer, Bruno, Simon, Nicolas, Söderpalm, Bo, Somaini, Lorenzo, Sommer, Wolfgang H, Spanagel, Rainer, Walter, Henriette, van den Brink, Wim

“…Abstract Aims The estimated effect of sodium oxybate (SMO) in the treatment of alcohol dependence is heterogeneous. Population severity and treatment duration…”
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Progression of heart failure: a role for interstitial fibrosis by Sabbah, H N, Sharov, V G, Lesch, M, Goldstein, S

“…Progressive deterioration of left ventricular (LV) function is a characteristic feature of the heart failure (HF) state. The mechanism or mechanisms…”
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The concept of temperament in psychoactive substance use among college students by Unseld, Matthias, Dworschak, Giselle, Tran, Ulrich S, Plener, Paul L, Erfurth, Andreas, Walter, Henriette, Lesch, Otto-Michael, Kapusta, Nestor D

“…Abstract Background Substance abuse is among the leading causes of preventable diseases and premature death but reasons and conditions leading to substance…”
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Efficacy of flupentixol and risperidone in chronic schizophrenia with predominantly negative symptoms by Ruhrmann, Stephan, Kissling, Werner, Lesch, Otto-Michael, Schmauss, Max, Seemann, Ute, Philipp, Michael

“…The study investigated the non-inferiority of flupentixol compared to risperidone in the treatment of negative symptoms. In addition, the effects of…”
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Pesticide contamination of the upper Elbe River and an adjacent floodplain area by Karlsson, Anneli S., Lesch, Michael, Weihermüller, Lutz, Thiele, Björn, Disko, Ulrich, Hofmann, Diana, Vereecken, Harry, Spielvogel, Sandra

“…Purpose Pesticide contamination of river waters is a global problem, and therefore, authorities regularly monitor the water quality status. Especially, flood…”
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Reinnervation of the transplanted human heart as evidenced from heart rate variability studies by Halpert, Igor, Goldberg, A.David, Levine, Arlene B., Levine, T.Barry, Kornberg, Robert, Kelly, Colleen, Lesch, Michael

“…This study evaluated heart rate variability (HRV) after cardiac transplantation in humans in an attempt to test the hypothesis that cardiac reinnervation…”
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Myocardial Infarction (STEMI, Non-STEMI) by LESCH, Michael

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Heart rate variability and sudden death secondary to coronary artery disease during ambulatory electrocardiographic monitoring by Martin, Gary J., Magid, Norman M., Myers, Glenn, Barnett, Phillip S., Schaad, John W., Weiss, Jerry S., Lesch, Michael, Singer, Donald H.

“…Data are analyzed from 5 patients who died suddenly during ambulatory electrocardiographic monitoring. Three of the patients were also assessed in terms of 2…”
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Coronary artery aneurysm: A review by Syed, Mushabbar, Lesch, Michael

“…Coronary artery aneurysm is defined as coronary dilatation which exceeds the diameter of normal adjacent segments or the diameter of the patient's largest…”
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PL6SUBGROUPS OF ADDICTION: FROM BASIC RESEARCH TO THERAPY by Lesch, Otto Michael

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Abnormalities of contractile structures in viable myocytes of the failing heart by Sharov, V G, Sabbah, H N, Shimoyama, H, Ali, A S, Levine, T B, Lesch, M, Goldstein, S

“…We examined the incidence and severity of abnormalities of contractile structures of residual viable cardiomyocytes in the left ventricular free wall, septum…”
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Idiopathic dilated cardiomyopathy as a late complication of healed viral (Coxsackie B virus) myocarditis: historical analysis, review of the literature, and a postulated unifying hypothesis by Spotnitz, Michelle D, Lesch, Michael

“…A historically based literature review of the relationship between acute viral myocarditis and the subsequent development of a dilated cardiomyopathic state is…”
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