Search Results - "Lesch, K.‐P."

Neural stem cell proliferation is decreased in schizophrenia, but not in depression by REIF, A, FRITZEN, S, FINGER, M, STROBEL, A, LAUER, M, SCHMITT, A, LESCH, K.-P

“…The phenomenon of adult neurogenesis (AN), that is, the generation of functional neurons from neural stem cells in the dentate gyrus of the hippocampus, has…”
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The ADHD-susceptibility gene lphn3.1 modulates dopaminergic neuron formation and locomotor activity during zebrafish development by Lange, M, Norton, W, Coolen, M, Chaminade, M, Merker, S, Proft, F, Schmitt, A, Vernier, P, Lesch, K-P, Bally-Cuif, L

“…Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, increased impulsivity and emotion…”
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Epigenetic regulation of the BDNF gene: implications for psychiatric disorders by Boulle, F, van den Hove, D L A, Jakob, S B, Rutten, B P, Hamon, M, van Os, J, Lesch, K-P, Lanfumey, L, Steinbusch, H W, Kenis, G

“…Abnormal brain-derived neurotrophic factor (BDNF) signaling seems to have a central role in the course and development of various neurological and psychiatric…”
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Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531 by WENDLAND, J. R, MARTIN, B. J, KRUSE, M. R, LESCH, K.-P, MURPHY, D. L

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The genetics of attention deficit/hyperactivity disorder in adults, a review by Franke, B, Faraone, S V, Asherson, P, Buitelaar, J, Bau, C H D, Ramos-Quiroga, J A, Mick, E, Grevet, E H, Johansson, S, Haavik, J, Lesch, K-P, Cormand, B, Reif, A

“…The adult form of attention deficit/hyperactivity disorder (aADHD) has a prevalence of up to 5% and is the most severe long-term outcome of this common…”
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Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice by Wellman, C L, Izquierdo, A, Garrett, J E, Martin, K P, Carroll, J, Millstein, R, Lesch, K-P, Murphy, D L, Holmes, A

“…A lesser-expressing form of the human 5-HT transporter (5-HTT) gene has been associated with increased fear and anxiety and vulnerability to the effects of…”
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Increased fear learning, spatial learning as well as neophobia in Rgs2−/− mice by Raab, A., Popp, S., Lesch, K.‐P., Lohse, M. J., Fischer, M., Deckert, J., Hommers, L.

“…Anxiety disorders result from a complex interplay of genetic and environmental factors such as stress. On the level of cellular signaling, regulator of G…”
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Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder by Rutten, B P F, Vermetten, E, Vinkers, C H, Ursini, G, Daskalakis, N P, Pishva, E, de Nijs, L, Houtepen, L C, Eijssen, L, Jaffe, A E, Kenis, G, Viechtbauer, W, van den Hove, D, Schraut, K G, Lesch, K-P, Kleinman, J E, Hyde, T M, Weinberger, D R, Schalkwyk, L, Lunnon, K, Mill, J, Cohen, H, Yehuda, R, Baker, D G, Maihofer, A X, Nievergelt, C M, Geuze, E, Boks, M P M

“…In order to determine the impact of the epigenetic response to traumatic stress on post-traumatic stress disorder (PTSD), this study examined longitudinal…”
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OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency by Ullrich, M, Weber, M, Post, A M, Popp, S, Grein, J, Zechner, M, Guerrero González, H, Kreis, A, Schmitt, A G, Üçeyler, N, Lesch, K-P, Schuh, K

“…Obsessive-compulsive disorder (OCD) is a common neuropsychiatric disease affecting about 2% of the general population. It is characterized by persistent…”
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A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function by REIF, A, HERTERICH, S, SCHMITT, A, FALLGATTER, A. J, LESCH, K.-P, STROBEL, A, EHLIS, A.-C, SAUR, D, JACOB, C. P, WIENKER, T, TÖPNER, T, FRITZEN, S, WALTER, U

“…Nitric oxide (NO) is a gaseous neurotransmitter thought to play important roles in several behavioral domains. On a neurobiological level, NO acts as the…”
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Serotonergic innervation and serotonin receptor expression of NPY-producing neurons in the rat lateral and basolateral amygdaloid nuclei by Bonn, M., Schmitt, A., Lesch, K.-P., Van Bockstaele, E. J., Asan, E.

“…Pharmacobehavioral studies in experimental animals, and imaging studies in humans, indicate that serotonergic transmission in the amygdala plays a key role in…”
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Genome-wide copy number variation analysis in attention-deficit hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree by Lesch, K-P, Selch, S, Renner, T J, Jacob, C, Nguyen, T T, Hahn, T, Romanos, M, Walitza, S, Shoichet, S, Dempfle, A, Heine, M, Boreatti-Hümmer, A, Romanos, J, Gross-Lesch, S, Zerlaut, H, Wultsch, T, Heinzel, S, Fassnacht, M, Fallgatter, A, Allolio, B, Schäfer, H, Warnke, A, Reif, A, Ropers, H-H, Ullmann, R

“…Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental syndrome characterized by hyperactivity, inattention and…”
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MAOA gene hypomethylation in panic disorder—reversibility of an epigenetic risk pattern by psychotherapy by Ziegler, C, Richter, J, Mahr, M, Gajewska, A, Schiele, M A, Gehrmann, A, Schmidt, B, Lesch, K-P, Lang, T, Helbig-Lang, S, Pauli, P, Kircher, T, Reif, A, Rief, W, Vossbeck-Elsebusch, A N, Arolt, V, Wittchen, H-U, Hamm, A O, Deckert, J, Domschke, K

“…Epigenetic signatures such as methylation of the monoamine oxidase A ( MAOA ) gene have been found to be altered in panic disorder (PD). Hypothesizing temporal…”
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A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication by Arcos-Burgos, M, Jain, M, Acosta, M T, Shively, S, Stanescu, H, Wallis, D, Domené, S, Vélez, J I, Karkera, J D, Balog, J, Berg, K, Kleta, R, Gahl, W A, Roessler, E, Long, R, Lie, J, Pineda, D, Londoño, A C, Palacio, J D, Arbelaez, A, Lopera, F, Elia, J, Hakonarson, H, Johansson, S, Knappskog, P M, Haavik, J, Ribases, M, Cormand, B, Bayes, M, Casas, M, Ramos-Quiroga, J A, Hervas, A, Maher, B S, Faraone, S V, Seitz, C, Freitag, C M, Palmason, H, Meyer, J, Romanos, M, Walitza, S, Hemminger, U, Warnke, A, Romanos, J, Renner, T, Jacob, C, Lesch, K-P, Swanson, J, Vortmeyer, A, Bailey-Wilson, J E, Castellanos, F X, Muenke, M

“…Attention-Deficit/Hyperactivity Disorder (ADHD) has a very high heritability (0.8), suggesting that about 80% of phenotypic variance is due to genetic factors…”
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Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder by Jarick, I, Volckmar, A-L, Pütter, C, Pechlivanis, S, Nguyen, T T, Dauvermann, M R, Beck, S, Albayrak, Ö, Scherag, S, Gilsbach, S, Cichon, S, Hoffmann, P, Degenhardt, F, Nöthen, M M, Schreiber, S, Wichmann, H-E, Jöckel, K-H, Heinrich, J, Tiesler, C M T, Faraone, S V, Walitza, S, Sinzig, J, Freitag, C, Meyer, J, Herpertz-Dahlmann, B, Lehmkuhl, G, Renner, T J, Warnke, A, Romanos, M, Lesch, K-P, Reif, A, Schimmelmann, B G, Hebebrand, J, Scherag, A, Hinney, A

“…Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental disorder. Genetic loci have not yet been identified by…”
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Dopamine D4 receptor gene variation impacts self-reported altruism by Anacker, K, Enge, S, Reif, A, Lesch, K-P, Strobel, A

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No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state by Bruzzone, S E P, Ozenne, B, Fisher, P M, Ortega, G, Jensen, P S, Dam, V H, Svarer, C, Knudsen, G M, Lesch, K P, Frokjaer, V G

“…Methylation of serotonin-related genes has been proposed as a plausible gene-by-environment link which may mediate environmental stress, depressive and anxiety…”
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Serotonin deficiency induced after brain maturation rescues consequences of early life adversity by Aboagye, B., Weber, T., Merdian, H. L., Bartsch, D., Lesch, K. P., Waider, J.

“…Brain serotonin (5-HT) system dysfunction is implicated in depressive disorders and acute depletion of 5-HT precursor tryptophan has frequently been used to…”
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Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition by Rivero, O, Selten, M M, Sich, S, Popp, S, Bacmeister, L, Amendola, E, Negwer, M, Schubert, D, Proft, F, Kiser, D, Schmitt, A G, Gross, C, Kolk, S M, Strekalova, T, van den Hove, D, Resink, T J, Nadif Kasri, N, Lesch, K P

“…Cadherin-13 (CDH13), a unique glycosylphosphatidylinositol-anchored member of the cadherin family of cell adhesion molecules, has been identified as a risk…”
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The ADHD-linked gene Lphn3.1 controls locomotor activity and impulsivity in zebrafish by Lange, M, Norton, W, Coolen, M, Chaminade, M, Merker, S, Proft, F, Schmitt, A, Vernier, P, Lesch, K-P, Bally-Cuif, L

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