Search Results - "Lesch, Charles"

Radical Democracy’s Religion: Hobbes on Language, Domination, and Self-Creation by Lesch, Charles H. T

“…In recent decades, prominent political theorists have responded to perceived flaws in liberalism by proposing more “radical” forms of democracy. What might a…”
Get full text

Against Politics: Walter Benjamin on Justice, Judaism, and the Possibility of Ethics by LESCH, CHARLES H. T.

“…Is politics compatible with the moral life? Recent attempts to revivify democracy have stressed the lived experience of political activity, the democratic…”
Get full text

Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor‑γ (RORγ) Agonist for Use in Treating Cancer by Aicher, Thomas D, Van Huis, Chad A, Hurd, Alexander R, Skalitzky, Donald J, Taylor, Clarke B, Beleh, Omar M, Glick, Gary, Toogood, Peter L, Yang, Bing, Zheng, Tao, Huo, Changxin, Gao, Jie, Qiao, Chenxi, Tian, Xiaolong, Zhang, Junping, Demock, Kellie, Hao, Ling-Yang, Lesch, Charles A, Morgan, Rodney W, Moisan, Jacques, Wang, Yahong, Scatina, JoAnn, Paulos, Chrystal M, Zou, Weiping, Carter, Laura L, Hu, Xiao

“…Retinoic acid receptor-related orphan receptor γ (RORc, RORγ, or NR1F3) is the nuclear receptor master transcription factor that drives the function and…”
Get full text

What undermines solidarity? Four approaches and their implications for contemporary political theory by Lesch, Charles H. T.

“…Solidarity is crucial for realizing justice, securing public goods, and reducing domination. Yet there have been few theoretical studies of its threats and…”
Get full text

Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity by Hu, Xiao, Liu, Xikui, Moisan, Jacques, Wang, Yahong, Lesch, Charles A., Spooner, Chauncey, Morgan, Rodney W., Zawidzka, Elizabeth M., Mertz, David, Bousley, Dick, Majchrzak, Kinga, Kryczek, Ilona, Taylor, Clarke, Van Huis, Chad, Skalitzky, Don, Hurd, Alexander, Aicher, Thomas D., Toogood, Peter L., Glick, Gary D., Paulos, Chrystal M., Zou, Weiping, Carter, Laura L.

“…RORγt is the key transcription factor controlling the development and function of CD4 + Th17 and CD8 + Tc17 cells. Across a range of human tumors, about 15% of…”
Get full text

Junctional adhesion molecule-C is a soluble mediator of angiogenesis by Rabquer, Bradley J, Amin, Mohammad A, Teegala, Nanditha, Shaheen, Matthew K, Tsou, Pei-Suen, Ruth, Jeffrey H, Lesch, Charles A, Imhof, Beat A, Koch, Alisa E

“…Junctional adhesion molecule-C (JAM-C) is an adhesion molecule expressed by endothelial cells (ECs) that plays a role in tight junction formation, leukocyte…”
Get full text

Discovery and Characterization of a Novel Inhibitor of Matrix Metalloprotease-13 That Reduces Cartilage Damage in Vivo without Joint Fibroplasia Side Effects by Johnson, Adam R., Pavlovsky, Alexander G., Ortwine, Daniel F., Prior, Faith, Man, Chiu-Fai, Bornemeier, Dirk A., Banotai, Craig A., Mueller, W. Thomas, McConnell, Patrick, Yan, Chunhong, Baragi, Vijay, Lesch, Charles, Roark, W. Howard, Wilson, Michael, Datta, Kaushik, Guzman, Roberto, Han, Hyo-Kyung, Dyer, Richard D.

“…Matrix metalloproteinase-13 (MMP13) is a Zn2+-dependent protease that catalyzes the cleavage of type II collagen, the main structural protein in articular…”
Get full text

Lesch, Charles H.T.: Solidarity in a secular age: from political theology to Jewish philosophy by Kaminsky, J.S

Get full text

Phenotypic and Functional Analysis of Murine Resident and Induced Peritoneal Macrophages by Turchyn, Lyubomyr R, Baginski, Theodore J, Renkiewicz, Richard R, Lesch, Charles A, Mobley, James L

“…Primary macrophages from the peritoneal cavities of mice are commonly used ex vivo to produce inflammatory cytokines and test anti-inflammatory agents…”
Get full text

Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease by Glick, Gary D, Rossignol, Rodrigue, Lyssiotis, Costas A, Wahl, Daniel, Lesch, Charles, Sanchez, Brian, Liu, Xikui, Hao, Ling-Yang, Taylor, Clarke, Hurd, Alexander, Ferrara, James L M, Tkachev, Victor, Byersdorfer, Craig A, Boros, Laszlo, Opipari, Anthony W

“…T-cell activation requires increased ATP and biosynthesis to support proliferation and effector function. Most models of T-cell activation are based on in…”
Get more information

Broad‐spectrum matrix metalloproteinase inhibitor marimastat–induced musculoskeletal side effects in rats by Renkiewicz, Richard, Qiu, Luping, Lesch, Charles, Sun, Xin, Devalaraja, Radhika, Cody, Theresa, Kaldjian, Eric, Welgus, Howard, Baragi, Vijaykumar

“…Objective To characterize the clinical and histopathologic changes in a rat model of broad‐spectrum matrix metalloproteinase (MMP)–induced musculoskeletal…”
Get full text

Abstract 565: RORγ agonists regulate immune checkpoint receptors to enhance anti-tumor immunity by Hu, Xiao, Liu, Xikui, Moisan, Jacques, Paulos, Chrystal, Wang, Yahong, Spooner, Chauncey, Lesch, Charles, Morgan, Rodney, Mertz, David, Bousley, Dick, Taylor, Clarke, Van Huis, Chad, Skalitzky, Don, Aicher, Thomas, Toogood, Peter, Carter, Laura

“…Abstract As the master transcription factor for Type 17 T cells, RORγt activates a program of gene expression associated with enhancing effector function and…”
Get full text

Abstract 565: ROR agonists regulate immune checkpoint receptors to enhance anti-tumor immunity by Hu, Xiao, Liu, Xikui, Moisan, Jacques, Paulos, Chrystal, Wang, Yahong, Spooner, Chauncey, Lesch, Charles, Morgan, Rodney, Mertz, David, Bousley, Dick, Taylor, Clarke, Van Huis, Chad, Skalitzky, Don, Aicher, Thomas, Toogood, Peter, Carter, Laura

“…As the master transcription factor for Type 17 T cells, RORt activates a program of gene expression associated with enhancing effector function and overcoming…”
Get full text

Abstract 4273: RORγ agonists as a novel immunotherapy approach for cancer by Hu, Xiao, Moisan, Jacques, Lesch, Charles, Wang, Yahong, Liu, Xikui, Morgan, Rodney, Mertz, David, Sanchez, Brian, Bousley, Dick, Taylor, Clark, Van Huis, Chad, Aicher, Thomas, Toogood, Peter, Zou, Weiping, Glick, Gary, Carter, Laura L.

“…Abstract Agents that enhance activation or release suppression of the immune system could form the basis of new treatments for cancer. RORγt is the key…”
Get full text

Interleukin-18 as an in vivo mediator of monocyte recruitment in rodent models of rheumatoid arthritis by Ruth, Jeffrey H, Park, Christy C, Amin, M Asif, Lesch, Charles, Marotte, Hubert, Shahrara, Shiva, Koch, Alisa E

“…The function of interleukin-18 (IL-18) was investigated in pertinent animal models of rodent rheumatoid arthritis (RA) to determine its proinflammatory and…”
Get full text

Deep Solidarity: Political Theology, Jewish Thought, and Liberal Commitment in a Secular Age by Taylor Lesch, Charles Harry

“…Solidarity is crucial for liberalism. It helps to stabilize society, realize justice, diminish domination, and cultivate moral personality. Yet the sources of…”
Get full text

Su1387 F1F0-ATPase Modulation Is Efficacious in Models in IBD and Induces Apoptosis of Human CCR9+ Gut-Tropic T-cells by Franchi, Luigi, Hlavaty, Kelan A, Monteleone, Ivan, Morgan, Rodney, Porzondek, Kelli, Sanchez, Brian, Lesch, Charles, Spahr, Mark A, Hepburn, Corrin, Opipari, Anthony W, Monteleone, Giovanni, Glick, Gary, Carter, Laura, Higgins, Peter D

Get full text

Suppression of CC chemokine production and HMVEC chemotaxis by green tea extract by Ahmed, Salahuddin, Marotte, Hubert, Ruth, Jeffrey H, Campbell, Phillip L, Lesch, Charles, Koch, Alisa E

“…In the present study, we tested the efficacy of polyphenol‐containing green tea extract (GTE) in regulating CC chemokine production in human rheumatoid…”
Get full text

Interleukin-18 as an in vivomediator of monocyte recruitment in rodent models of rheumatoid arthritis by Ruth, Jeffrey H, Park, Christy C, Amin, M Asif, Lesch, Charles, Marotte, Hubert, Shahrara, Shiva, Koch, Alisa E

“…Abstract Introduction The function of interleukin-18 (IL-18) was investigated in pertinent animal models of rodent rheumatoid arthritis (RA) to determine its…”
Get full text

Novel synthetic RORγ agonist compounds as a potential anti-tumor therapeutic approach by Hu, Xiao, Liu, Xikui, Morgan, Rodney, Moisan, Jacques, Hao, Ling-Yang, Wang, Yahong, Sanchez, Brian, Lesch, Charles, Bousley, Dick, Taylor, Clark, Aicher, Thomas, Toogood, Peter, Zou, Weiping, Glick, Gary, Carter, Laura

“…IntroductionSelective enhancement (or activation) of the immune system by novel small molecules may be a potential therapeutic approach for the treatment of…”
Get full text