Search Results - "Lesburg, C A"

Crystal Structure of Pentalenene Synthase: Mechanistic Insights on Terpenoid Cyclization Reactions in Biology by Lesburg, Charles A., Zhai, Guangzhi, Cane, David E., Christianson, David W.

“…The crystal structure of pentalenene synthase at 2.6 angstrom resolution reveals critical active site features responsible for the cyclization of farnesyl…”
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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site by Weber, Patricia C, Lesburg, Charles A, Cable, Michael B, Ferrari, Eric, Hong, Zhi, Mannarino, Anthony F

“…Various classes of nucleotidyl polymerases with different transcriptional roles contain a conserved core structure. Less is known, however, about the…”
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Template/Primer Requirements and Single Nucleotide Incorporation by Hepatitis C Virus Nonstructural Protein 5B Polymerase by Zhong, W, Ferrari, E, Lesburg, C A, Maag, D, Ghosh, S K, Cameron, C E, Lau, J Y, Hong, Z

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Reversal of the Hydrogen Bond to Zinc Ligand Histidine-119 Dramatically Diminishes Catalysis and Enhances Metal Equilibration Kinetics in Carbonic Anhydrase II by Huang, Chih-chin, Lesburg, Charles A, Kiefer, Laura L, Fierke, Carol A, Christianson, David W

“…Direct metal ligands to transition metals in metalloproteins exert a profound effect on protein−metal affinity and function. Indirect ligands, i.e.,…”
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Managing and manipulating carbocations in biology: terpenoid cyclase structure and mechanism by Lesburg, Charles A, Caruthers, Jonathan M, Paschall, Chiana M, Christianson, David W

“…Terpenoid cyclases catalyze remarkably complex cyclization cascades that are initiated by the formation of a highly reactive carbocation in a polyisoprene…”
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Crystallization and preliminary X‐ray diffraction analysis of recombinant pentalenene synthase by Lesburg, Charles A., Lloyd, Matthew D., Cane, David E., Christianson, David W.

“…Recombinant pentalenene synthase, a 42.5‐kDa sesquiterpene cyclase originally isolated from Streptomyces UC5319 and cloned in Escherichia coli, has been…”
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Histidine → Carboxamide Ligand Substitutions in the Zinc Binding Site of Carbonic Anhydrase II Alter Metal Coordination Geometry but Retain Catalytic Activity by Lesburg, Charles A, Huang, Chih-chin, Christianson, David W, Fierke, Carol A

“…The catalytic zinc ion of human carbonic anhydrase II (CAII) is coordinated by three histidine ligands (H94, H96, and H119) and a hydroxide ion with…”
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Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability by Wang, Wenyan, Prosise, Winifred W., Chen, Jun, Taremi, S. Shane, Le, Hung V., Madison, Vincent, Cui, Xiaoming, Thomas, Ann, Cheng, K.-C., Lesburg, Charles A.

“…The nuclear xenobiotic receptor PXR is a ligand-inducible transcription factor regulating drug-metabolizing enzymes and transporters and a master switch…”
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soaPDB: a web application for searching the Protein Data Bank, organizing results, and receiving automatic email alerts by Lesburg, Charles A, Duca, José S

“…soaPDB is a web application that allows generation and organization of saved PDB searches, and offers automatic email alerts. This tool is used from a web…”
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Active-site engineering of carbonic anhydrase and its application to biosensors by Hunt, J A, Lesburg, C A, Christianson, D W, Thompson, R B, Fierke, C A

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X-ray crystallographic studies of engineered hydrogen bond networks in a protein-zinc binding site by Lesburg, Charles A, Christianson, David W

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Recent advances in the analysis of HCV NS5B RNA-dependent RNA polymerase by Lesburg, C A, Radfar, R, Weber, P C

“…An RNA-dependent RNA polymerase denoted nonstructural protein 5B (NS5B) is the central enzyme in replication of the hepatitis C virus genome. Recent advances…”
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