Search Results - "Leroy, Kaat"

Benchmarking of methods for DNA methylome deconvolution by De Ridder, Kobe, Che, Huiwen, Leroy, Kaat, Thienpont, Bernard

“…Defining the number and abundance of different cell types in tissues is important for understanding disease mechanisms as well as for diagnostic and prognostic…”
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Connexin-Based Channel Activity Is Not Specifically Altered by Hepatocarcinogenic Chemicals by Leroy, Kaat, Pieters, Alanah, Cooreman, Axelle, Van Campenhout, Raf, Cogliati, Bruno, Vinken, Mathieu

“…Connexin-based channels play key roles in cellular communication and can be affected by deleterious chemicals. In this study, the effects of various genotoxic…”
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In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach by Tabernilla, Andrés, dos Santos Rodrigues, Bruna, Pieters, Alanah, Caufriez, Anne, Leroy, Kaat, Van Campenhout, Raf, Cooreman, Axelle, Gomes, Ana Rita, Arnesdotter, Emma, Gijbels, Eva, Vinken, Mathieu

“…The liver is among the most frequently targeted organs by noxious chemicals of diverse nature. Liver toxicity testing using laboratory animals not only raises…”
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Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals by Vilas-Boas, Vânia, Gijbels, Eva, Leroy, Kaat, Pieters, Alanah, Baze, Audrey, Parmentier, Céline, Vinken, Mathieu

“…Drug-induced liver injury, including cholestasis, is an important clinical issue and economic burden for pharmaceutical industry and healthcare systems…”
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Expression and Functionality of Connexin-Based Channels in Human Liver Cancer Cell Lines by Leroy, Kaat, Silva Costa, Cícero Júlio, Pieters, Alanah, Dos Santos Rodrigues, Bruna, Van Campenhout, Raf, Cooreman, Axelle, Tabernilla, Andrés, Cogliati, Bruno, Vinken, Mathieu

“…Liver cancer cell lines are frequently used in vitro tools to test candidate anti-cancer agents as well as to elucidate mechanisms of liver carcinogenesis…”
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Effects of Drugs Formerly Suggested for COVID-19 Repurposing on Pannexin1 Channels by Caufriez, Anne, Tabernilla, Andrés, Van Campenhout, Raf, Cooreman, Axelle, Leroy, Kaat, Sanz Serrano, Julen, Kadam, Prashant, Dos Santos Rodrigues, Bruna, Lamouroux, Arthur, Ballet, Steven, Vinken, Mathieu

“…Although many efforts have been made to elucidate the pathogenesis of COVID-19, the underlying mechanisms are yet to be fully uncovered. However, it is known…”
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Effects of Drugs Formerly Proposed for COVID-19 Treatment on Connexin43 Hemichannels by Cooreman, Axelle, Caufriez, Anne, Tabernilla, Andrés, Van Campenhout, Raf, Leroy, Kaat, Kadam, Prashant, Sanz Serrano, Julen, Dos Santos Rodrigues, Bruna, Annaert, Pieter, Vinken, Mathieu

“…Connexin43 (Cx43) hemichannels form a pathway for cellular communication between the cell and its extracellular environment. Under pathological conditions,…”
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Cholestasis Differentially Affects Liver Connexins by Cooreman, Axelle, Van Campenhout, Raf, Crespo Yanguas, Sara, Gijbels, Eva, Leroy, Kaat, Pieters, Alanah, Tabernilla, Andrés, Van Brantegem, Pieter, Annaert, Pieter, Cogliati, Bruno, Vinken, Mathieu

“…Connexins are goal keepers of tissue homeostasis, including in the liver. As a result, they are frequently involved in disease. The current study was set up to…”
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Expression of connexins and pannexins in diseased human liver by Leroy, Kaat, Vilas-Boas, Vânia, Gijbels, Eva, Vanderborght, Bart, Devisscher, Lindsey, Cogliati, Bruno, Van Den Bossche, Bert, Colle, Isabelle, Vinken, Mathieu

“…Connexin proteins can form hexameric hemichannels and gap junctions that mediate paracrine and direct intercellular communication, respectively. Gap junction…”
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Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation by Van Campenhout, Raf, Crespo Yanguas, Sara, Cooreman, Axelle, Gijbels, Eva, Leroy, Kaat, Vilas-Boas, Vânia, Devoogdt, Nick, Muyldermans, Serge, Cogliati, Bruno, Vinken, Mathieu

“…Adherens junctions, consisting of cadherins and catenins, are a group of cell-to-cell junctions that mediate mechanistic linkage between neighboring cells. By…”
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Evaluation of functional candidate biomarkers of non-genotoxic hepatocarcinogenicity in human liver spheroid co-cultures by dos Santos Rodrigues, Bruna, Leroy, Kaat, Mihajlovic, Milos, De Boever, Sybren, Vanbellingen, Sarah, Cogliati, Bruno, Aerts, Joeri L., Vinken, Mathieu

“…Validated in vitro assays for testing non-genotoxic carcinogenic potential of chemicals are currently not available. Consequently, the two-year rodent bioassay…”
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Industrial, Biocide, and Cosmetic Chemical Inducers of Cholestasis by Vilas-Boas, Vânia, Gijbels, Eva, Cooreman, Axelle, Van Campenhout, Raf, Gustafson, Emma, Leroy, Kaat, Vinken, Mathieu

“…A frequent side effect of many drugs includes the occurrence of cholestatic liver toxicity. Over the past couple of decades, drug-induced cholestasis has…”
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Impact of doubling peptide length on in vivo hydrogel stability and sustained drug release by Heremans, Julie, Chevillard, Lucie, Mannes, Morgane, Mangialetto, Jessica, Leroy, Kaat, White, Jacinta F., Lamouroux, Arthur, Vinken, Mathieu, Gardiner, James, Van Mele, Bruno, Van den Brande, Niko, Hoogenboom, Richard, Madder, Annemieke, Caveliers, Vicky, Mégarbane, Bruno, Hernot, Sophie, Ballet, Steven, Martin, Charlotte

“…Peptide-based hydrogels represent promising systems for the sustained release of different types of drugs, ranging from small molecules to biologicals. Aiming…”
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Impact of doubling peptide length on in vivo hydrogel stability and sustained drug release by Heremans, Julie, Chevillard, Lucie, Mannes, Morgane, Mangialetto, Jessica, Leroy, Kaat, White, Jacinta, Lamouroux, Arthur, Vinken, Mathieu, Gardiner, James, van Mele, Bruno, van den Brande, Niko, Hoogenboom, Richard, Madder, Annemieke, Caveliers, Vicky, Mégarbane, Bruno, Hernot, Sophie, Ballet, Steven, Martin, Charlotte

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Non-canonical roles of connexins by Van Campenhout, Raf, Cooreman, Axelle, Leroy, Kaat, Rusiecka, Olga M., Van Brantegem, Pieter, Annaert, Pieter, Muyldermans, Serge, Devoogdt, Nick, Cogliati, Bruno, Kwak, Brenda R., Vinken, Mathieu

“…Gap junctions mediate cellular communication and homeostasis by controlling the intercellular exchange of small and hydrophilic molecules and ions. Gap…”
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Targeting gap junctional intercellular communication by hepatocarcinogenic compounds by Leroy, Kaat, Pieters, Alanah, Tabernilla, Andrés, Cooreman, Axelle, Van Campenhout, Raf, Cogliati, Bruno, Vinken, Mathieu

“…Gap junctions in liver, as in other organs, play a critical role in tissue homeostasis. Inherently, these cellular constituents are major targets for systemic…”
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In Vivo and In Vitro Models of Hepatocellular Carcinoma: Current Strategies for Translational Modeling by Romualdo, Guilherme Ribeiro, Leroy, Kaat, Costa, Cícero Júlio Silva, Prata, Gabriel Bacil, Vanderborght, Bart, da Silva, Tereza Cristina, Barbisan, Luís Fernando, Andraus, Wellington, Devisscher, Lindsey, Câmara, Niels Olsen Saraiva, Vinken, Mathieu, Cogliati, Bruno

“…Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer-related death globally. HCC is a complex…”
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Connexin-Based Channels in the Liver by Van Campenhout, Raf, Leroy, Kaat, Cooreman, Axelle, Tabernilla, Andrés, Cogliati, Bruno, Kadam, Prashant, Vinken, Mathieu

“…Connexin proteins oligomerize in hexameric structures called connexin hemichannels, which then dock to form gap junctions. Gap junctions direct cell-cell…”
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