Search Results - "Leroux, Michel R"

The roles of evolutionarily conserved functional modules in cilia-related trafficking by Sung, Ching-Hwa, Leroux, Michel R.

“…Cilia are present across most eukaryotic phyla and have diverse sensory and motility functions. Sung and Leroux review the trafficking pathways that modulate…”
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Shared and Distinct Mechanisms of Compartmentalized and Cytosolic Ciliogenesis by Avidor-Reiss, Tomer, Leroux, Michel R.

“…Most motile and all non-motile (also known as primary) eukaryotic cilia possess microtubule-based axonemes that are assembled at the cell surface to form…”
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IFT trains overcome an NPHP module barrier at the transition zone by Park, Kwangjin, Leroux, Michel R

“…Cilia harbor diffusion barriers for soluble and membrane proteins within their proximal-most transition zone (TZ) region and employ an intraflagellar transport…”
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MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis by Williams, Corey L, Li, Chunmei, Kida, Katarzyna, Inglis, Peter N, Mohan, Swetha, Semenec, Lucie, Bialas, Nathan J, Stupay, Rachel M, Chen, Nansheng, Blacque, Oliver E, Yoder, Bradley K, Leroux, Michel R

“…Meckel-Gruber syndrome (MKS), nephronophthisis (NPHP), and related ciliopathies present with overlapping phenotypes and display considerable allelism between…”
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Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia by Silverman, Michael A, Leroux, Michel R

“…Cilia are organelles that project from most eukaryotic organisms and cell types. Their pervasiveness stems from having remarkably versatile propulsive and…”
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Striated Rootlet and Nonfilamentous Forms of Rootletin Maintain Ciliary Function by Mohan, Swetha, Timbers, Tiffany A., Kennedy, Julie, Blacque, Oliver E., Leroux, Michel R.

“…Primary cilia are microtubule-based sensory organelles whose structures and functions must be actively maintained throughout animal lifespan to support signal…”
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C. elegans PPEF-type phosphatase (Retinal degeneration C ortholog) functions in diverse classes of cilia to regulate nematode behaviors by Barbelanne, Marine, Lu, Yun, Kumar, Keerthana, Zhang, Xinxing, Li, Chunmei, Park, Kwangjin, Warner, Adam, Xu, X. Z. Shawn, Shaham, Shai, Leroux, Michel R.

“…Primary (non-motile) cilia represent structurally and functionally diverse organelles whose roles as specialized cellular antenna are central to animal cell…”
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MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone by Li, Chunmei, Jensen, Victor L, Park, Kwangjin, Kennedy, Julie, Garcia-Gonzalo, Francesc R, Romani, Marta, De Mori, Roberta, Bruel, Ange-Line, Gaillard, Dominique, Doray, Bérénice, Lopez, Estelle, Rivière, Jean-Baptiste, Faivre, Laurence, Thauvin-Robinet, Christel, Reiter, Jeremy F, Blacque, Oliver E, Valente, Enza Maria, Leroux, Michel R

“…Cilia have a unique diffusion barrier ("gate") within their proximal region, termed transition zone (TZ), that compartmentalises signalling proteins within the…”
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Quality control of cytoskeletal proteins and human disease by Lundin, Victor F., Leroux, Michel R., Stirling, Peter C.

“…Actins and tubulins are abundant cytoskeletal proteins that support diverse cellular processes. Owing to the unique properties of these filament-forming…”
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Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling by Yee, Laura E, Garcia-Gonzalo, Francesc R, Bowie, Rachel V, Li, Chunmei, Kennedy, Julie K, Ashrafi, Kaveh, Blacque, Oliver E, Leroux, Michel R, Reiter, Jeremy F

“…Mutations in genes encoding cilia proteins cause human ciliopathies, diverse disorders affecting many tissues. Individual genes can be linked to ciliopathies…”
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TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone by Roberson, Elle C, Dowdle, William E, Ozanturk, Aysegul, Garcia-Gonzalo, Francesc R, Li, Chunmei, Halbritter, Jan, Elkhartoufi, Nadia, Porath, Jonathan D, Cope, Heidi, Ashley-Koch, Allison, Gregory, Simon, Thomas, Sophie, Sayer, John A, Saunier, Sophie, Otto, Edgar A, Katsanis, Nicholas, Davis, Erica E, Attié-Bitach, Tania, Hildebrandt, Friedhelm, Leroux, Michel R, Reiter, Jeremy F

“…The Meckel syndrome (MKS) complex functions at the transition zone, located between the basal body and axoneme, to regulate the localization of ciliary…”
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Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport by Jensen, Victor L, Carter, Stephen, Sanders, Anna A W M, Li, Chunmei, Kennedy, Julie, Timbers, Tiffany A, Cai, Jerry, Scheidel, Noemie, Kennedy, Breandán N, Morin, Ryan D, Leroux, Michel R, Blacque, Oliver E

“…Primary cilia are specialised sensory and developmental signalling devices extending from the surface of most eukaryotic cells. Defects in these organelles…”
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The interaction network of the chaperonin CCT by Dekker, Carien, Stirling, Peter C, McCormack, Elizabeth A, Filmore, Heather, Paul, Angela, Brost, Renee L, Costanzo, Michael, Boone, Charles, Leroux, Michel R, Willison, Keith R

“…The eukaryotic cytosolic chaperonin containing TCP‐1 (CCT) has an important function in maintaining cellular homoeostasis by assisting the folding of many…”
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Genes and molecular pathways underpinning ciliopathies by Reiter, Jeremy F., Leroux, Michel R.

“…Key Points There are two types of cilia, motile and non-motile primary, which have different roles in human physiology, cell signalling and development…”
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Functional coordination of intraflagellar transport motors by Snow, Joshua J, Leroux, Michel R, Ou, Guangshuo, Scholey, Jonathan M, E. Blacque, Oliver

“…Cilia have diverse roles in motility and sensory reception, and defects in cilia function contribute to ciliary diseases such as Bardet-Biedl syndrome (BBS)…”
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Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors by Pan, Xiaoyu, Ou, Guangshuo, Civelekoglu-Scholey, Gul, Blacque, Oliver E, Endres, Nicholas F, Tao, Li, Mogilner, Alex, Leroux, Michel R, Vale, Ronald D, Scholey, Jonathan M

“…The assembly and function of cilia on Caenorhabditis elegans neurons depends on the action of two kinesin-2 motors, heterotrimeric kinesin-II and homodimeric…”
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Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT) by Timbers, Tiffany A, Garland, Stephanie J, Mohan, Swetha, Flibotte, Stephane, Edgley, Mark, Muncaster, Quintin, Au, Vinci, Li-Leger, Erica, Rosell, Federico I, Cai, Jerry, Rademakers, Suzanne, Jansen, Gert, Moerman, Donald G, Leroux, Michel R

“…Forward genetic screens represent powerful, unbiased approaches to uncover novel components in any biological process. Such screens suffer from a major…”
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Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome by Katsanis, Nicholas, Ansley, Stephen J, Badano, Jose L, Blacque, Oliver E, Hill, Josephine, Hoskins, Bethan E, Leitch, Carmen C, Chul Kim, Jun, Ross, Alison J, Eichers, Erica R, Teslovich, Tanya M, Mah, Allan K, Johnsen, Robert C, Cavender, John C, Alan Lewis, Richard, Leroux, Michel R, Beales, Philip L

“…Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized primarily by retinal dystrophy, obesity, polydactyly, renal malformations and…”
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Composition, organization and mechanisms of the transition zone, a gate for the cilium by Park, Kwangjin, Leroux, Michel R

“…The cilium evolved to provide the ancestral eukaryote with the ability to move and sense its environment. Acquiring these functions required the…”
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The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression by Leroux, Michel R, Katsanis, Nicholas, Kim, Jun Chul, Badano, Jose L, Sibold, Sonja, Esmail, Muneer A, Hill, Josephine, Hoskins, Bethan E, Leitch, Carmen C, Venner, Kerrie, Ansley, Stephen J, Ross, Alison J, Beales, Philip L

“…BBS4 is one of several proteins that cause Bardet-Biedl syndrome (BBS), a multisystemic disorder of genetic and clinical complexity. Here we show that BBS4…”
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