Search Results - "Leroux, Hugo"

Towards achieving semantic interoperability of clinical study data with FHIR by Leroux, Hugo, Metke-Jimenez, Alejandro, Lawley, Michael J

“…Observational clinical studies play a pivotal role in advancing medical knowledge and patient healthcare. To lessen the prohibitive costs of conducting these…”
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A FHIR Native Radiology Informatics Platform by Raniga, Parnesh, Min, Hang, Leroux, Hugo

“…FHIR is a new standard that is rapidly being adopted in healthcare. We describe and implement a Radiology informatics platform (RIS) that is FHIR native and…”
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Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture by Zhang, Qian, Sidorenko, Julia, Couvy-Duchesne, Baptiste, Marioni, Riccardo E., Wright, Margaret J., Goate, Alison M., Marcora, Edoardo, Huang, Kuan-lin, Porter, Tenielle, Laws, Simon M., Sachdev, Perminder S., Mather, Karen A., Armstrong, Nicola J., Thalamuthu, Anbupalam, Brodaty, Henry, Yengo, Loic, Yang, Jian, Wray, Naomi R., McRae, Allan F., Visscher, Peter M.

“…Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer’s disease (LOAD). However, LOAD genetic…”
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Clinical Implementation of Routine Whole-genome Sequencing for Hospital Infection Control of Multi-drug Resistant Pathogens by Forde, Brian M, Bergh, Haakon, Cuddihy, Thom, Hajkowicz, Krispin, Hurst, Trish, Playford, E Geoffrey, Henderson, Belinda C, Runnegar, Naomi, Clark, Julia, Jennison, Amy V, Moss, Susan, Hume, Anna, Leroux, Hugo, Beatson, Scott A, Paterson, David L, Harris, Patrick N A

“…Abstract Background Prospective whole-genome sequencing (WGS)-based surveillance may be the optimal approach to rapidly identify transmission of multi-drug…”
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Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease by Roe, James M., Vidal-Piñeiro, Didac, Sørensen, Øystein, Brandmaier, Andreas M., Düzel, Sandra, Gonzalez, Hector A., Kievit, Rogier A., Knights, Ethan, Kühn, Simone, Lindenberger, Ulman, Mowinckel, Athanasia M., Nyberg, Lars, Park, Denise C., Pudas, Sara, Rundle, Melissa M., Walhovd, Kristine B., Fjell, Anders M., Westerhausen, René

“…Aging and Alzheimer’s disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the…”
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Semantic enrichment of longitudinal clinical study data using the CDISC standards and the semantic statistics vocabularies by Leroux, Hugo, Lefort, Laurent

“…There is an increasing recognition of the need for the data capture phase of clinical studies to be improved and for more effective sharing of clinical data…”
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On selecting a clinical trial management system for large scale, multi-centre, multi-modal clinical research study by Leroux, Hugo, McBride, Simon, Gibson, Simon

“…Clinical research studies offer many challenges for their supporting information systems. AIBL assembled 1112 participants who volunteered crucial information…”
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Author Correction: Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease by Roe, James M., Vidal-Piñeiro, Didac, Sørensen, Øystein, Brandmaier, Andreas M., Düzel, Sandra, Gonzalez, Hector A., Kievit, Rogier A., Knights, Ethan, Kühn, Simone, Lindenberger, Ulman, Mowinckel, Athanasia M., Nyberg, Lars, Park, Denise C., Pudas, Sara, Rundle, Melissa M., Walhovd, Kristine B., Fjell, Anders M., Westerhausen, René

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Investigation of current models of care for genetic heart disease in Australia: A national clinical audit by Austin, Rachel, Quinn, Michael C.J., Afoakwah, Clifford, Metke-Jimenez, Alejandro, Leroux, Hugo, Atherton, John, Brown, Jaye S., Wornham, Linda J., Macciocca, Ivan, de Silva, Michelle G., Thompson, Tina, Martin, Ellenore M., Hilton, Desiree, Devery, Sophie, Wu, Kathy H.C., Jackson, Matilda R., Correnti, Gemma, Overkov, Angela, Elbracht-Leong, Stefanie, Ingles, Jodie, Scuffham, Paul, Semsarian, Christopher, McGaughran, Julie

“…This sub-study of the Australian Genomics Cardiovascular Genetic Disorders Flagship sought to conduct the first nation-wide audit in Australia to establish the…”
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A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort by Pedrini, Steve, Gupta, Veer B., Hone, Eugene, Doecke, James, O’Bryant, Sid, James, Ian, Bush, Ashley I., Rowe, Christopher C., Villemagne, Victor L., Ames, David, Masters, Colin L., Martins, Ralph N.

“…Alzheimer’s Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary…”
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Abstract 4920: Evaluation of a diagnostic blood test for colorectal cancer screening and as a triage tool to stratify patients for colonoscopy by Cosgrove, Leah J., Surinya, Kathy, Fung, Kim YC, Priebe, Ilka, Buckley, Mike, Adams, Tim, Tabor, Bruce, Purins, Leanne, Lockett, Trevor, Leroux, Hugo, Gibbs, Peter, Wei, Jiangqin, Nice, Ed, Burgess, Tony, Thomas, Michelle, Moore, James, Singh, Raj, Ruszkiewicz, Andrew

“…Worldwide, colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer death, with an annual incidence in 2012 of 1.4…”
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High Content, Multi-Parameter Analyses in Buccal Cells to Identify Alzheimer's Disease by François, Maxime, Fenech, Michael F, Thomas, Philip, Hor, Maryam, Rembach, Alan, Martins, Ralph N, Rainey-Smith, Stephanie R, Masters, Colin L, Ames, David, Rowe, Christopher C, Macaulay, S Lance, Hill, Andrew F, Leifert, Wayne R, The Australian Imaging Biomarkers And Lifestyle Study Research Group

“…Alzheimer's disease (AD) is a degenerative brain disorder and is the most common form of dementia. Minimally invasive approaches are required that combine…”
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A method for the semantic enrichment of clinical trial data by Leroux, Hugo, McBride, Simon, Lefort, Laurent, Kemp, Madonna, Gibson, Simon

“…Clinical trial data have historically been implemented using relational databases. While this has expedited the dissemination of data among partners, it has…”
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Using Australian medicines terminology (AMT) and SNOMED CT-AU to better support clinical research by McBride, Simon J, Lawley, Michael J, Leroux, Hugo, Gibson, Simon

“…A large scale, long term clinical study faced significant quality issues with its medications use data which had been collected from participants using paper…”
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Promoting the Secondary Use of Clinical Research Data in Australia by Leroux, Hugo, Dallest, Kathy, Kang, Kristan, Gottliebsen, Sara, Gorse, Dominique, Guillen, Diego, Hansen, David

“…The research community in Australia is building a national infrastructure to facilitate access to and sharing of data from health studies. A federation of nine…”
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Prediction of Antibiotic Susceptibility in E. coli Isolates Using Machine Learning by Talamantes-Becerra, Berenice, Wickramarachchi, Anuradha, Bauer, Denis C, Sng, Letitia, Nguyen, Anthony, Twine, Natalie, Leroux, Hugo

“…Antimicrobial resistance (AMR) poses a significant global health threat, resulting in 4.96 million deaths in 2019, with projections reaching 10 million by…”
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