Search Results - "Leroux, Frédéric"

Ketenimines as Intermediates To Access Difluoromethoxylated Scaffolds by Loison, Anaïs, Hanquet, Gilles, Toulgoat, Fabien, Billard, Thierry, Panossian, Armen, Leroux, Frédéric R.

“…We report herein the in situ generation of difluoromethoxylated ketenimines. This novel intermediate is readily obtained from the corresponding oxime through a…”
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Synthesis of diversely fluorinated pyrazoles as novel active agrochemical ingredients by Giornal, Florence, Pazenok, Sergiy, Rodefeld, Lars, Lui, Norbert, Vors, Jean-Pierre, Leroux, Frédéric R.

“…[Display omitted] ► We describe the recently reported syntheses of 3-difluoromethyl pyrazoles. ► We outline the use of FAR reagents as difluoromethyl-transfer…”
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Deprotonative Functionalization of the Difluoromethyl Group by Santos, Laura, Panossian, Armen, Donnard, Morgan, Vors, Jean-Pierre, Pazenok, Sergii, Bernier, David, Leroux, Frédéric R

“…The functionalization of 3-(difluoromethyl)­pyridine has been developed via direct deprotonation of -CHF2 with a lithiated base and subsequent trapping with…”
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Direct Deprotonative Functionalization of α,α‐Difluoromethyl Ketones using a Catalytic Organosuperbase by Messara, Amélia, Panossian, Armen, Mikami, Koichi, Hanquet, Gilles, Leroux, Frédéric R.

“…The deprotonative functionalization of α,α‐difluoromethyl ketones is described herein. Using a catalytic organosuperbase and a silane additive, the…”
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Palladium‐Catalyzed Silylcyanation of Ynamides: Regio‐ and Stereoselective Access to Tetrasubstituted 3‐Silyl‐2‐Aminoacrylonitriles by Hansjacob, Pierre, Leroux, Frédéric R., Gandon, Vincent, Donnard, Morgan

“…The palladium‐catalyzed silylcyanation of ynamides is described. This reaction is fully regioselective, delivering tetrasubstituted 2‐aminoacrylonitriles…”
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Comprehensive Study and Development of a Metal‐Free and Mild Nucleophilic Trifluoromethoxylation by Bonnefoy, Clémence, Panossian, Armen, Hanquet, Gilles, Leroux, Frédéric R., Toulgoat, Fabien, Billard, Thierry

“…Among the general interest in fluorinated compounds, trifluoromethoxylated molecules play a specific role. However, despite this interest, the development of…”
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Versatile Access to Tetrasubstituted 2‑Amidoacroleins through Formal Silylformylation of Ynamides by Golling, Stéphane, Leroux, Frédéric R, Donnard, Morgan

“…In this paper we are reporting the first regio- and stereoselective silylformylation of ynamides. This reaction is tolerant to a wide range of functional…”
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Asymmetric α‑Sulfonyl- and α‑Phosphoryl-Oxylation of Ketones by a Chiral Hypervalent Iodine(III) by Levitre, Guillaume, Dumoulin, Audrey, Retailleau, Pascal, Panossian, Armen, Leroux, Frédéric R, Masson, Géraldine

“…An enantioselective direct oxygenation of propiophenone derivatives mediated by a catalytic or stoichiometric amount of new chiral non-C2-symmetric…”
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Direct Access to 2,3-Disubstituted Amido-Indenones through Annulation of 2‑Iodobenzaldehydes with Ynamides by Golling, Stéphane, Hansjacob, Pierre, Bami, Nassim, Leroux, Frédéric R., Donnard, Morgan

“…In this paper we report the annulation reaction between 2-iodobenzaldehyde derivatives and various ynamides. This palladium-catalyzed reaction leads to rare…”
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Zinc‐Catalyzed Hydrocyanation of Ynamides and Photoisomerization, a General and Selective Access to E and Z Trisubstituted α‐Enamidonitriles by Hansjacob, Pierre, Leroux, Frédéric R., Donnard, Morgan

“…The fully regio‐ and stereoselective Zn‐catalyzed hydrocyanation of ynamides is reported and represents a general access to various trisubstituted…”
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Recent advances in transition metal-catalyzed Csp(2)-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation by Landelle, Grégory, Panossian, Armen, Pazenok, Sergiy, Vors, Jean-Pierre, Leroux, Frédéric R

“…In the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented…”
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A Major Advance in the Synthesis of Fluoroalkyl Pyrazoles: Tuneable Regioselectivity and Broad Substitution Patterns by Schmitt, Etienne, Panossian, Armen, Vors, Jean-Pierre, Funke, Christian, Lui, Norbert, Pazenok, Sergiy, Leroux, Frédéric R.

“…A novel approach towards highly functionalized fluoroalkyl pyrazoles was developed by using fluoroalkyl amino reagents in combination with a variety of…”
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Synthesis and Use of Trifluoromethylthiolated Ketenimines by Guérin, Thomas, Pikun, Nadiia V., Morioka, Ryutaro, Panossian, Armen, Hanquet, Gilles, Leroux, Frédéric R.

“…The synthesis of trifluoromethylthiolated ketenimines is herein described. They are easily synthesized from the corresponding α‐trifluoromethylthiolated oximes…”
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Unlocking the Power of Acyl Fluorides: A Comprehensive Guide to Synthesis and Properties by Bonnefoy, Clémence, Gallego, Adrien, Delobel, Clément, Raynal, Betty, Decourt, Maxime, Chefdeville, Emmanuel, Hanquet, Gilles, Panossian, Armen, Leroux, Frédéric R., Toulgoat, Fabien, Billard, Thierry

“…Abstract Acyl fluorides have emerged as versatile reagents in various synthetic endeavors, offering a range of advantages over their counterparts, acyl…”
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Atropodiastereoselective CH Olefination of Biphenyl p-Tolyl Sulfoxides with Acrylates by Wesch, Thomas, Leroux, Frédéric R., Colobert, Françoise

“…A stereoselective method for the synthesis of axially chiral biaryl scaffolds by CH bond functionalization was accomplished using chiral sulfoxide both as the…”
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Ruthenium‐Catalyzed Synthesis of Aryl and Alkenyl Halides from Fluorosulfonates by Plaçais, Clotilde, Kaldas, Sherif J., Donnard, Morgan, Panossian, Armen, Bernier, David, Pazenok, Sergii, Leroux, Frédéric R.

“…Aryl and alkenyl halides are widely used as key intermediates in organic synthesis, particularly for the formation of organometallic reagents or as radical…”
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Recent synthetic methods towards the –OCHF2 moiety by Loison, Anaïs, Toulgoat, Fabien, Billard, Thierry, Hanquet, Gilles, Panossian, Armen, Leroux, Frédéric R.

“…The fluorine atom and fluorinated substituents are currently key motifs in pharmaceutical and agrochemical active ingredients, since they often beneficially…”
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Traceless N‐Polyfluoroalkylation of Weakly Nucleophilic Nitrogen Containing Compounds by Santos, Laura, Audet, Florian, Donnard, Morgan, Panossian, Armen, Vors, Jean‐Pierre, Bernier, David, Pazenok, Sergii, Leroux, Frédéric R.

“…Here we report an efficient access to high‐value N‐polyfluoroalkyl anilines, primary polyfluoroalkylamines and N,N‐bis(polyfluoroalkyl)amines, via…”
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In Situ Generated Fluorinated Iminium Salts for Difluoromethylation and Difluoroacetylation by Schmitt, Etienne, Rugeri, Baptiste, Panossian, Armen, Vors, Jean-Pierre, Pazenok, Sergii, Leroux, Frédéric R

“…The use of TFEDMA, a fluoroalkyl amino reagent, for the difluoromethylation and difluoroacylation of arenes, heteroarenes, and C–H acidic compounds is…”
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One‐step Oxidative Monofluorination of Electron‐Deficient Sulfoxides to Access Highly Lewis Acidic Sulfur(VI) Cations by Berreur, Jordan, Diez‐Varga, Alberto, Manel, Augustin, Leroux, Frédéric R., Panossian, Armen

“…The strongly oxidizing, powerful electrophilic fluorination reagent [FXe][OTf] is shown to effect direct oxidative monofluorination of sulfoxides. This…”
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