Search Results - "Lerouge, Patrice"
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PECTIN METHYLESTERASE48 Is Involved in Arabidopsis Pollen Grain Germination
Published in Plant physiology (Bethesda) (01-02-2015)“…Germination of pollen grains is a crucial step in plant reproduction. However, the molecular mechanisms involved remain unclear. We investigated the role of…”
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Diatom-Specific Oligosaccharide and Polysaccharide Structures Help to Unravel Biosynthetic Capabilities in Diatoms
Published in Marine Drugs (01-09-2015)“…Diatoms are marine organisms that represent one of the most important sources of biomass in the ocean, accounting for about 40% of marine primary production,…”
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Analysis of the Arabidopsis IRX9/IRX9-L and IRX14/IRX14-L Pairs of Glycosyltransferase Genes Reveals Critical Contributions to Biosynthesis of the Hemicellulose Glucuronoxylan
Published in Plant physiology (Bethesda) (01-06-2010)“…The hemicellulose glucuronoxylan (GX) is a major component of plant secondary cell walls. However, our understanding of GX synthesis remains limited. Here, we…”
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Investigation of the N -Glycosylation of the SARS-CoV-2 S Protein Contained in VLPs Produced in Nicotiana benthamiana
Published in Molecules (Basel, Switzerland) (11-08-2022)“…The emergence of the SARS-CoV-2 coronavirus pandemic in China in late 2019 led to the fast development of efficient therapeutics. Of the major structural…”
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N - and O -Glycosylation Pathways in the Microalgae Polyphyletic Group
Published in Frontiers in plant science (17-12-2020)“…The term microalga refers to various unicellular and photosynthetic organisms representing a polyphyletic group. It gathers numerous species, which can be…”
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Microalgae as an Efficient Vehicle for the Production and Targeted Delivery of Therapeutic Glycoproteins against SARS-CoV-2 Variants
Published in Marine drugs (23-10-2022)“…Severe acute respiratory syndrome–Coronavirus 2 (SARS-CoV-2) can infect various human organs, including the respiratory, circulatory, nervous, and…”
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Biochemical Characterization of Human Anti-Hepatitis B Monoclonal Antibody Produced in the Microalgae Phaeodactylum tricornutum
Published in PloS one (05-10-2015)“…Monoclonal antibodies (mAbs) represent actually the major class of biopharmaceuticals. They are produced recombinantly using living cells as biofactories…”
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The Light-Controlled Release of 2-fluoro-l-fucose, an Inhibitor of the Root Cell Elongation, from a nitrobenzyl-caged Derivative
Published in International journal of molecular sciences (28-01-2023)“…Glycan metabolic engineering is a powerful tool for studying the glycosylation in living plant cells. The use of modified monosaccharides such as deoxy or…”
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Cell wall O-glycoproteins and N-glycoproteins: aspects of biosynthesis and function
Published in Frontiers in plant science (02-10-2014)“…Cell wall O-glycoproteins and N-glycoproteins are two types of glycomolecules whose glycans are structurally complex. They are both assembled and modified…”
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Arabidopsis IRX10 and IRX10-LIKE glycosyltransferases are critical for glucuronoxylan biosynthesis during secondary cell wall formation
Published in The Plant journal : for cell and molecular biology (01-02-2009)“…Arabidopsis IRX10 and IRX10-LIKE (IRX10-L) proteins are closely related members of the GT47 glycosyltransferase family. Single gene knock-outs of IRX10 or…”
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The SARS-CoV-2 Spike Protein Receptor-Binding Domain Expressed in Rice Callus Features a Homogeneous Mix of Complex-Type Glycans
Published in International journal of molecular sciences (18-04-2024)“…The spike protein receptor-binding domain (RBD) of SARS-CoV-2 is required for the infection of human cells. It is the main target that elicits neutralizing…”
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Characterization of a GDP-Fucose Transporter and a Fucosyltransferase Involved in the Fucosylation of Glycoproteins in the Diatom Phaeodactylum tricornutum
Published in Frontiers in plant science (21-05-2019)“…Although is gaining importance in plant molecular farming for the production of high-value molecules such as monoclonal antibodies, little is currently known…”
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Inhibition of fucosylation of cell wall components by 2‐fluoro 2‐deoxy‐l‐fucose induces defects in root cell elongation
Published in The Plant journal : for cell and molecular biology (01-12-2015)“…Screening of commercially available fluoro monosaccharides as putative growth inhibitors in Arabidopsis thaliana revealed that 2‐fluoro 2‐l‐fucose (2F‐Fuc)…”
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Two tomato GDP-D-mannose epimerase isoforms involved in ascorbate biosynthesis play specific roles in cell wall biosynthesis and development
Published in Journal of experimental botany (01-08-2016)“…GDP-D-mannose epimerase (GME, EC 5.1.3.18) converts GDP-D-mannose to GDP-L-galactose, and is considered to be a central enzyme connecting the major ascorbate…”
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Brassica rapa hairy root based expression system leads to the production of highly homogenous and reproducible profiles of recombinant human alpha‐L‐iduronidase
Published in Plant biotechnology journal (01-02-2019)“…Summary The Brassica rapa hairy root based expression platform, a turnip hairy root based expression system, is able to produce human complex glycoproteins…”
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Effect of Arabinogalactan Proteins from the Root Caps of Pea and Brassica napus on Aphanomyces euteiches Zoospore Chemotaxis and Germination
Published in Plant physiology (Bethesda) (01-08-2012)“…Root tips of many plant species release a number of border, or border-like, cells that are thought to play a major role in the protection of root meristem…”
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Exploring the N-glycosylation Pathway in Chlamydomonas reinhardtii Unravels Novel Complex Structures
Published in Molecular & cellular proteomics (01-11-2013)“…Chlamydomonas reinhardtii is a green unicellular eukaryotic model organism for studying relevant biological and biotechnological questions. The availability of…”
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cell wall pectic polymer rhamnogalacturonan-II is required for proper pollen tube elongation: implications of a putative sialyltransferase-like protein
Published in Annals of botany (01-10-2014)“…Background and AimsRhamnogalacturonan-II (RG-II) is one of the pectin motifs found in the cell wall of all land plants. It contains sugars such as…”
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Protein N-glycosylation in eukaryotic microalgae and its impact on the production of nuclear expressed biopharmaceuticals
Published in Frontiers in plant science (28-07-2014)“…Microalgae are currently used for the production of food compounds. Recently, few microalgae species have been investigated as potential biofactories for the…”
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Performance of plant-produced RBDs as SARS-CoV-2 diagnostic reagents: a tale of two plant platforms
Published in Frontiers in plant science (01-01-2023)“…The COVID-19 pandemic has underscored the need for rapid and cost-effective diagnostic tools. Serological tests, particularly those measuring antibodies…”
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