Search Results - "Lerner, C."

Pushing Past the Blockade: Advancements in T Cell-Based Cancer Immunotherapies by Waibl Polania, Jessica, Lerner, Emily C, Wilkinson, Daniel S, Hoyt-Miggelbrink, Alexandra, Fecci, Peter E

“…Successful cancer immunotherapies rely on a replete and functional immune compartment. Within the immune compartment, T cells are often the effector arm of…”
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Pain and Empathy by Lerner, Joshua C., MD

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HGF and c-Met Participate in Paracrine Tumorigenic Pathways in Head and Neck Squamous Cell Cancer by KNOWLES, Lynn M, STABILE, Laura P, MORGAN, Sarah, FERRIS, Robert L, GRANDIS, Jennifer R, SIEGFRIED, Jill M, EGLOFF, Ann Marie, ROTHSTEIN, Mary E, THOMAS, Sufi M, GUBISH, Christopher T, LERNER, Edwina C, SEETHALA, Raja R, SUZUKI, Shinsuke, QUESNELLE, Kelly M

“…Purpose: We determined hepatocyte growth factor (HGF) and c-Met expression and signaling in human head and neck squamous cell carcinoma (HNSCC) cells and…”
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Risk of Tract Seeding Following Laser Interstitial Thermal Therapy for Brain Tumors by Haskell-Mendoza, Aden P, Srinivasan, Ethan S, Lerner, Emily C, Edwards, Ryan M, Schwalb, Allison M, Jackson, Joshua D, Hardigan, Andrew A, Vaios, Eugene J, Fecci, Peter E

“…The management of intracranial oncological disease remains a significant challenge despite advances in systemic cancer therapy. Laser interstitial thermal…”
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Condolence Card by Lerner, Joshua C., MD

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CD8 + T cells maintain killing of MHC-I-negative tumor cells through the NKG2D-NKG2DL axis by Lerner, Emily C, Woroniecka, Karolina I, D'Anniballe, Vincent M, Wilkinson, Daniel S, Mohan, Aditya A, Lorrey, Selena J, Waibl-Polania, Jessica, Wachsmuth, Lucas P, Miggelbrink, Alexandra M, Jackson, Joshua D, Cui, Xiuyu, Raj, Jude A, Tomaszewski, William H, Cook, Sarah L, Sampson, John H, Patel, Anoop P, Khasraw, Mustafa, Gunn, Michael D, Fecci, Peter E

“…The accepted paradigm for both cellular and anti-tumor immunity relies upon tumor cell killing by CD8 T cells recognizing cognate antigens presented in the…”
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Src Kinases Mediate STAT Growth Pathways in Squamous Cell Carcinoma of the Head and Neck by Xi, Sichuan, Zhang, Qing, Dyer, Kevin F., Lerner, Edwina C., Smithgall, Thomas E., Gooding, William E., Kamens, Joanne, Grandis, Jennifer Rubin

“…Signal transducer and activator of transcription (STAT) proteins are constitutively activated in many malignancies, including squamous cell carcinoma of the…”
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Imaging prognostication and tumor biology in hepatocellular carcinoma by Kadi, Diana, Yamamoto, Marilyn F., Lerner, Emily C., Jiang, Hanyu, Fowler, Kathryn J., Bashir, Mustafa R.

“…Hepatocellular carcinoma (HCC) is the most common primary liver malignancy, and represents a significant global health burden with rising incidence rates,…”
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Burying bullying by Lerner, Joshua C.

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Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases by Lerner, Emily C., Srinivasan, Ethan S., Broadwater, Gloria, Haskell-Mendoza, Aden P., Edwards, Ryan M., Huie, David, Vaios, Eugene J., Floyd, Scott R., Adamson, Justus D., Fecci, Peter E.

“…Stereotactic radiosurgery (SRS) is a highly effective therapy for newly diagnosed brain metastases. Prophylactic antiepileptic drugs are no longer routinely…”
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149 Influence of miR-146a and miR-155 on cell proliferation and migration in head and neck squamous cell carcinoma by Lerner, C, Bochen, F, Kulas, P, Linxweiler, M, Hasenfus, A, Heinzelmann, J, Schick, B, Wemmert, S

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Phosphorylation of the Varicella-Zoster Virus (VZV) Major Transcriptional Regulatory Protein IE62 by the VZV Open Reading Frame 66 Protein Kinase by EISFELD, Amie J, TURSE, Stephanie E, JACKSON, Sara A, LERNER, Edwina C, KINCHINGTON, Paul R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Control of myeloid differentiation and survival by Stats by Smithgall, T E, Briggs, S D, Schreiner, S, Lerner, E C, Cheng, H, Wilson, M B

“…Hematopoiesis involves a complex array of growth factors that regulate the survival and proliferation of immature progenitors, influence differentiation…”
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Laser ablation: Heating up the anti-tumor response in the intracranial compartment by Lerner, Emily C., Edwards, Ryan M., Wilkinson, Daniel S., Fecci, Peter E.

“…[Display omitted] Immunotherapies, such as immune checkpoint inhibition (ICI), have had limited success in treating intracranial malignancies. These failures…”
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P03-17 IGF-I on the dark side: Negative consequences of IGF-I on mitochondrial homeostasis by Sell, C, Bitto, A, Lerner, C, Torres, C

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Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines by LERNER, E. C, ZHANG, T.-T, KNOWLES, D. B, QIAN, Y, HAMILTON, A. D, SEBTI, S. M

“…The farnesyltransferase (FTase) inhibitor FTI-277 is highly effective at blocking oncogenic H-Ras but not K-Ras4B processing and signaling. While inhibition of…”
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An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry by Hochrein, James M., Lerner, Edwina C., Schiavone, Anthony P., Smithgall, Thomas E., Engen, John R.

“…The ability of proteins to regulate their own enzymatic activity can be facilitated by changes in structure or protein dynamics in response to external…”
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SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo by Smithgall, Thomas E, Lerner, Edwina C

“…Src family protein-tyrosine kinase activity is suppressed by two intramolecular interactions. These involve binding of the SH2 domain to the phosphorylated…”
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Activation of the Src Family Kinase Hck without SH3-Linker Release by Lerner, Edwina C., Trible, Ronald P., Schiavone, Anthony P., Hochrein, James M., Engen, John R., Smithgall, Thomas E.

“…Src family protein-tyrosine kinases are regulated by intramolecular binding of the SH2 domain to the C-terminal tail and association of the SH3 domain with the…”
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Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes () by Lerner, Edwina C., Qian, Yimin, Blaskovich, Michelle A., Fossum, Renae D., Vogt, Andreas, Sun, Jiazhi, Cox, Adrienne D., Der, Channing J., Hamilton, Andrew D., Sebti, Saïd M.

“…Ras-induced malignant transformation requires Ras farnesylation, a lipid posttranslational modification catalyzed by farnesyltransferase (FTase). Inhibitors of…”
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