Search Results - "Lerm, M"

On the relationship between BCG coverage and national COVID‐19 outcome: could ‘heterologous’ herd immunity explain why some countries are better off? by Lerm, M.

“…The COVID‐19 pandemic has affected most parts of the global society since its emergence, and the scientific community has been challenged with questions…”
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Good old BCG – what a century‐old vaccine can contribute to modern medicine by Locht, C., Lerm, M.

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Trained immunity: a new avenue for tuberculosis vaccine development by Lerm, M., Netea, M. G.

“…Adaptive immunity towards tuberculosis (TB) has been extensively studied for many years. In addition, in recent years the profound contribution of innate…”
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Toward the understanding of human tuberculosis by Brighenti, S., Lerm, M.

“…Content List ‐ Read more articles from the symposium: “The 10th International Conference on the Pathogenesis of Mycobacterial Infections”…”
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Cardiorespiratory dysautonomia in post-COVID-19 condition: Manifestations, mechanisms and management by Fedorowski, Artur, Olsén, Monika Fagevik, Nikesjö, Frida, Janson, Christer, Bruchfeld, Judith, Lerm, Maria, Hedman, Kristofer

“…A significant proportion of COVID-19 patients experience debilitating symptoms for months after the acute infection. According to recent estimates,…”
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Addressing diversity in tuberculosis using multidimensional approaches by Lerm, M., Dockrell, H. M.

“…Tuberculosis is a complex disease, which can affect many organs other than the lungs. Initial infection may be cleared without inducing immunological memory,…”
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Parental TB associated with offspring asthma and rhinitis by López-Cervantes, J. P., Shigdel, R., Accordini, S., Mustafa, T., Bertelsen, R. J., Makvandi-Nejad, S., Lerm, M., Horsnell, W., Svanes, C.

“…BACKGROUND: Infections in early life are associated with asthma and allergies in one-generation settings; however, the link between parental infection and…”
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Shortening the ‘short‐course’ therapy– insights into host immunity may contribute to new treatment strategies for tuberculosis by Schön, T., Lerm, M., Stendahl, O.

“…Achieving global control of tuberculosis (TB) is a great challenge considering the current increase in multidrug resistance and mortality rate. Considerable…”
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Deamidation of Cdc42 and Rac by Escherichia coli cytotoxic necrotizing factor 1 : Activation of c-Jun N-terminal kinase in HeLa cells by LERM, M, SELZER, J, HOFFMEYER, A, RAPP, U. R, AKTORIES, K, SCHMIDT, G

“…Recently, Escherichia coli cytotoxic necrotizing factor 1 (CNF1) was shown to activate the low-molecular-mass GTPase RhoA by deamidation of Gln63, thereby…”
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Leishmania donovani Requires Functional Cdc42 and Rac1 To Prevent Phagosomal Maturation by Lerm, M, Holm, A, Seiron, A, Särndahl, E, Magnusson, K.-E, Rasmusson, B

“…Leishmania donovani promastigotes survive inside macrophage phagosomes by inhibiting phagosomal maturation. The main surface glycoconjugate on promastigotes,…”
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Toll-like receptor 2 stimulation of platelets is mediated by purinergic P2X1-dependent Ca2+ mobilisation, cyclooxygenase and purinergic P2Y1 and P2Y12 receptor activation by Kälvegren, H, Skoglund, C, Helldahl, C, Lerm, M, Grenegård, M, Bengtsson, T

“…Toll-like receptor 2 (TLR2), which recognise and respond to conserved microbial pathogen-associated molecular patterns, is expressed on the platelet surface…”
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Cognitive dysfunction in post‐COVID‐19 condition: Mechanisms, management, and rehabilitation by Möller, Marika, Borg, Kristian, Janson, Christer, Lerm, Maria, Normark, Johan, Niward, Katarina

“…Abstract The long‐term effects of COVID‐19 on cognitive function have become an area of increasing concern. This paper provides an overview of characteristics,…”
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Human macrophages infected with a high burden of ESAT-6-expressing M. tuberculosis undergo caspase-1- and cathepsin B-independent necrosis by Welin, Amanda, Eklund, Daniel, Stendahl, Olle, Lerm, Maria

“…Mycobacterium tuberculosis (Mtb) infects lung macrophages, which instead of killing the pathogen can be manipulated by the bacilli, creating an environment…”
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Inside or outside the phagosome? The controversy of the intracellular localization of Mycobacterium tuberculosis by Welin, Amanda, Lerm, Maria

“…Summary The localization of Mycobacterium tuberculosis (Mtb) inside the macrophage has been a matter of debate in recent years. Upon inhalation, the bacterium…”
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Polarization of Human Monocyte-Derived Cells With Vitamin D Promotes Control of Mycobacterium tuberculosis Infection by Rao Muvva, Jagadeeswara, Parasa, Venkata Ramanarao, Lerm, Maria, Svensson, Mattias, Brighenti, Susanna

“…Understanding macrophage behavior is key to decipher (Mtb) pathogenesis. We studied the phenotype and ability of human monocyte-derived cells polarized with…”
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A high content screening assay for discovery of antimycobacterial compounds based on primary human macrophages infected with virulent Mycobacterium tuberculosis by Kalsum, Sadaf, Otrocka, Magdalena, Andersson, Blanka, Welin, Amanda, Schön, Thomas, Jenmalm-Jensen, Annika, Lundbäck, Thomas, Lerm, Maria

“…Drug resistance in Mycobacterium tuberculosis is an emerging threat that makes the discovery of new candidate drugs a priority. In particular, drugs with high…”
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In memoriam: Rolf Hultcrantz (1949-2022) Obituary by Angelin, B, Andersson, J, Ekbom, A, Melander, O, Dahlqvist, P, Smedby, KE, Lerm, M, Hedbom, T, Cooper, E, Forsberg, N, de Faire, U

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A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis by Tenland, Erik, Krishnan, Nitya, Rönnholm, Anna, Kalsum, Sadaf, Puthia, Manoj, Mörgelin, Matthias, Davoudi, Mina, Otrocka, Magdalena, Alaridah, Nader, Glegola-Madejska, Izabela, Sturegård, Erik, Schmidtchen, Artur, Lerm, Maria, Robertson, Brian D., Godaly, Gabriela

“…Tuberculosis has been reaffirmed as the infectious disease causing most deaths in the world. Co-infection with HIV and the increase in multi-drug resistant…”
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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection by Braian, Clara, Svensson, Mattias, Brighenti, Susanna, Lerm, Maria, Parasa, Venkata R

“…Tuberculosis (TB) still holds a major threat to the health of people worldwide, and there is a need for cost-efficient but reliable models to help us…”
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Importance of Phagosomal Functionality for Growth Restriction of Mycobacterium tuberculosis in Primary Human Macrophages by Welin, Amanda, Raffetseder, Johanna, Eklund, Daniel, Stendahl, Olle, Lerm, Maria

“…The best characterized survival mechanism of Mycobacterium tuberculosis inside the macrophage is the inhibition of phagosomal maturation. Phagosomal maturation…”
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