Search Results - "Lerch, P."
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Patterns of Coordinated Anatomical Change in Human Cortical Development: A Longitudinal Neuroimaging Study of Maturational Coupling
Published in Neuron (Cambridge, Mass.) (08-12-2011)“…Understanding of human structural brain development has rapidly advanced in recent years, but remains fundamentally “localizational” in nature. Here, we use…”
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Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice
Published in Nature neuroscience (01-12-2017)“…Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally…”
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Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation
Published in Molecular psychiatry (01-02-2021)“…Infectious or noninfectious maternal immune activation (MIA) is an environmental risk factor for psychiatric and neurological disorders with neurodevelopmental…”
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Multi-atlas segmentation of the whole hippocampus and subfields using multiple automatically generated templates
Published in NeuroImage (Orlando, Fla.) (01-11-2014)“…Advances in image segmentation of magnetic resonance images (MRI) have demonstrated that multi-atlas approaches improve segmentation over regular atlas-based…”
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Longitudinal four-dimensional mapping of subcortical anatomy in human development
Published in Proceedings of the National Academy of Sciences - PNAS (28-01-2014)“…Growing access to large-scale longitudinal structural neuroimaging data has fundamentally altered our understanding of cortical development en route to human…”
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Organization of thalamocortical structural covariance and a corresponding 3D atlas of the mouse thalamus
Published in NeuroImage (Orlando, Fla.) (01-01-2024)“…For information from sensory organs to be processed by the brain, it is usually passed to appropriate areas of the cerebral cortex. Almost all of this…”
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Identification of a functional connectome for long-term fear memory in mice
Published in PLoS computational biology (01-01-2013)“…Long-term memories are thought to depend upon the coordinated activation of a broad network of cortical and subcortical brain regions. However, the distributed…”
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Normative brain size variation and brain shape diversity in humans
Published in Science (American Association for the Advancement of Science) (15-06-2018)“…Brain size variation over primate evolution and human development is associated with shifts in the proportions of different brain regions. Individual brain…”
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Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling
Published in Molecular psychiatry (01-09-2019)“…Atypical brain connectivity is a major contributor to the pathophysiology of neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASDs)…”
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Neuroanatomical Correlates of Musicianship as Revealed by Cortical Thickness and Voxel-Based Morphometry
Published in Cerebral cortex (New York, N.Y. 1991) (01-07-2009)“…We used a multimethod approach to investigate the neuroanatomical correlates of musicianship and absolute pitch (AP). Cortical thickness measures,…”
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Germline Chd8 haploinsufficiency alters brain development in mouse
Published in Nature neuroscience (01-08-2017)“…Strong genetic evidence points to a significant role for heterozygous mutations to general chromatin remodeling factors, such as CHD8, in autism. Gompers et al…”
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Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus
Published in Nature communications (19-01-2018)“…Early life experience influences stress reactivity and mental health through effects on cognitive-emotional functions that are, in part, linked to gene…”
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Neurodevelopmental Trajectories of the Human Cerebral Cortex
Published in The Journal of neuroscience (02-04-2008)“…Understanding the organization of the cerebral cortex remains a central focus of neuroscience. Cortical maps have relied almost exclusively on the examination…”
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Mouse MRI shows brain areas relatively larger in males emerge before those larger in females
Published in Nature communications (05-07-2018)“…Sex differences exist in behaviors, disease and neuropsychiatric disorders. Sexual dimorphisms however, have yet to be studied across the whole brain and…”
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Cortical thickness analysis examined through power analysis and a population simulation
Published in NeuroImage (Orlando, Fla.) (2005)“…We have previously developed a procedure for measuring the thickness of cerebral cortex over the whole brain using 3-D MRI data and a fully automated…”
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Imaging sex/gender and autism in the brain: Etiological implications
Published in Journal of neuroscience research (01-01-2017)“…The male preponderance in autism prevalence has brought together the disparate topics of sex/gender and autism research. Two directions of neuroimaging studies…”
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Neural Correlates of Familiarity in Music Listening: A Systematic Review and a Neuroimaging Meta-Analysis
Published in Frontiers in neuroscience (05-10-2018)“…Familiarity in music has been reported as an important factor modulating emotional and hedonic responses in the brain. Familiarity and repetition may increase…”
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Rotarod training in mice is associated with changes in brain structure observable with multimodal MRI
Published in NeuroImage (Orlando, Fla.) (15-02-2015)“…The brain has been shown to remain structurally plastic even throughout adulthood. However, little is known how motor-skill training affects different MRI…”
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Examining overlap and homogeneity in ASD, ADHD, and OCD: a data-driven, diagnosis-agnostic approach
Published in Translational psychiatry (26-11-2019)“…The validity of diagnostic labels of autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and obsessive compulsive disorder (OCD)…”
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Whole-brain comparison of rodent and human brains using spatial transcriptomics
Published in eLife (07-11-2022)“…The ever-increasing use of mouse models in preclinical neuroscience research calls for an improvement in the methods used to translate findings between mouse…”
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