Search Results - "Lerch, K"

Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract by Blackmore, Murray G, Wang, Zimei, Lerch, Jessica K, Motti, Dario, Zhang, Yi Ping, Shields, Christopher B, Lee, Jae K, Goldberg, Jeffrey L, Lemmon, Vance P, Bixby, John L

“…Axon regeneration in the central nervous system normally fails, in part because of a developmental decline in the intrinsic ability of CNS projection neurons…”
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The Effect of Glucocorticoid and Glucocorticoid Receptor Interactions on Brain, Spinal Cord, and Glial Cell Plasticity by Madalena, Kathryn M., Lerch, Jessica K.

“…Stress, injury, and disease trigger glucocorticoid (GC) elevation. Elevated GCs bind to the ubiquitously expressed glucocorticoid receptor (GR). While GRs are…”
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E6020, a synthetic TLR4 agonist, accelerates myelin debris clearance, Schwann cell infiltration, and remyelination in the rat spinal cord by Church, Jamie S., Milich, Lindsay M., Lerch, Jessica K., Popovich, Phillip G., McTigue, Dana M.

“…Oligodendrocyte progenitor cells (OPCs) are present throughout the adult brain and spinal cord and can replace oligodendrocytes lost to injury, aging, or…”
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Microglia Promote Increased Pain Behavior through Enhanced Inflammation in the Spinal Cord during Repeated Social Defeat Stress by Sawicki, Caroline M, Kim, January K, Weber, Michael D, Faw, Timothy D, McKim, Daniel B, Madalena, Kathryn M, Lerch, Jessica K, Basso, D Michele, Humeidan, Michelle L, Godbout, Jonathan P, Sheridan, John F

“…Clinical studies indicate that psychosocial stress contributes to adverse chronic pain outcomes in patients, but it is unclear how this is initiated or…”
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TLR4 Deficiency Impairs Oligodendrocyte Formation in the Injured Spinal Cord by Church, Jamie S, Kigerl, Kristina A, Lerch, Jessica K, Popovich, Phillip G, McTigue, Dana M

“…Acute oligodendrocyte (OL) death after traumatic spinal cord injury (SCI) is followed by robust neuron-glial antigen 2 (NG2)-positive OL progenitor…”
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Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells by Song, Anping, Zhu, Ling, Gorantla, Gowthami, Berdysz, Olimpia, Amici, Stephanie A., Guerau-de-Arellano, Mireia, Madalena, Kathryn M., Lerch, Jessica K., Liu, Xiaoyu, Quan, Ning

“…Interleukin 1 is a pleiotropic cytokine that mediates diverse functions through its receptor, type I interleukin 1 receptor (IL-1R1). Most previous studies…”
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Enhancing membrane repair increases regeneration in a sciatic injury model by Paleo, Brian J, Madalena, Kathryn M, Mital, Rohan, McElhanon, Kevin E, Kwiatkowski, Thomas A, Rose, Aubrey L, Lerch, Jessica K, Weisleder, Noah

“…Various injuries to the neural tissues can cause irreversible damage to multiple functions of the nervous system ranging from motor control to cognitive…”
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Transformation and additional malignancies are leading risk factors for an adverse course of disease in marginal zone lymphoma by Meyer, A.H., Stroux, A., Lerch, K., Eucker, J., Eitle, J., Hohloch, K., Andrzejak, M., Possinger, K., Dörken, B., Pezzutto, A., Scholz, C.W.

“…Marginal zone lymphoma (MZL) is a non-Hodgkin lymphoma that occurs as extra nodal, nodal, or splenic. While MZL is generally considered an indolent disease, a…”
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Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease by Shettigar, Vikram, Zhang, Bo, Little, Sean C., Salhi, Hussam E., Hansen, Brian J., Li, Ning, Zhang, Jianchao, Roof, Steve R., Ho, Hsiang-Ting, Brunello, Lucia, Lerch, Jessica K., Weisleder, Noah, Fedorov, Vadim V., Accornero, Federica, Rafael-Fortney, Jill A., Gyorke, Sandor, Janssen, Paul M. L., Biesiadecki, Brandon J., Ziolo, Mark T., Davis, Jonathan P.

“…Treatment for heart disease, the leading cause of death in the world, has progressed little for several decades. Here we develop a protein engineering approach…”
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A Genetic Approach to Access Serotonin Neurons for in vivo and in vitro Studies by Michael M. Scott, Christi J. Wylie, Jessica K. Lerch, Rox Anne Murphy, Katherine Lobur, Herlitze, Stefan, Weihong Jiang, Ron A. Conlon, Ben W. Strowbridge, Deneris, Evan S.

“…Serotonin (5HT) is a critical modulator of neural circuits that support diverse behaviors and physiological processes, and multiple lines of evidence implicate…”
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Isoform diversity and regulation in peripheral and central neurons revealed through RNA-Seq by Lerch, Jessica K, Kuo, Frank, Motti, Dario, Morris, Richard, Bixby, John L, Lemmon, Vance P

“…To fully understand cell type identity and function in the nervous system there is a need to understand neuronal gene expression at the level of isoform…”
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Towards a high-yield bioconversion of ferulic acid to vanillin by Muheim, A, Lerch, K

“…Natural vanillin is of high interest in the flavor market. Microbial routes to vanillin have so far not been economical as the medium concentrations achieved…”
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Serotonergic transcriptional programming determines maternal behavior and offspring survival by Beck, Sheryl G, Crawford, LaTasha K, Lerch-Haner, Jessica K, Deneris, Evan S, Frierson, Dargan

“…Central serotonergic signaling influences many physiological processes, but a requirement for reproductive success has not been demonstrated. Using mouse dams…”
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Achilles tendinosis is associated with sprouting of substance P positive nerve fibres by Schubert, T E O, Weidler, C, Lerch, K, Hofstädter, F, Straub, R H

“…Objectives: To identify and characterise nerve fibres and inflammatory alterations in painful Achilles tendinosis and thus gain evidence about the origin of…”
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Stress Increases Peripheral Axon Growth and Regeneration through Glucocorticoid Receptor-Dependent Transcriptional Programs by Lerch, Jessica K, Alexander, Jessica K, Madalena, Kathryn M, Motti, Dario, Quach, Tam, Dhamija, Akhil, Zha, Alicia, Gensel, John C, Webster Marketon, Jeanette, Lemmon, Vance P, Bixby, John L, Popovich, Phillip G

“…Stress and glucocorticoid (GC) release are common behavioral and hormonal responses to injury or disease. In the brain, stress/GCs can alter neuron structure…”
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Impact of prior treatment on outcome of transformed follicular lymphoma and relapsed de novo diffuse large B cell lymphoma: a retrospective multicentre analysis by Lerch, K., Meyer, A. H., Stroux, A., Hirt, C., Keller, U., Viardot, A., Marks, R., Schreiber, S., Pezzutto, A., Scholz, C. W.

“…Transformation of follicular lymphoma (FL) into aggressive disease and relapse of de novo diffuse large B cell lymphoma (DLBCL) are considered highly…”
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Glucocorticoids and nervous system plasticity by Madalena, Kathryn, Lerch, Jessica

“…Glucocorticoid and glucocorticoid receptor（GC/GR） interactions alter numerous aspects of neuronal function. These consequences（e.g., anti-inflammatory vs…”
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Lipoastrocytoma: a rare low-grade astrocytoma variant of pediatric age by GIANGASPERO, F, KAULICH, K, CENACCHI, G, CERASOLI, S, LERCH, K.-D, BREU, H, REUTER, T, REIFENBERGER, G

“…We report on two children with cerebral gliomas showing extensive lipomatous change of tumor cells. One tumor was a large mass occupying the temporal and…”
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Isoform diversity and its importance for axon regeneration by Lerch, Jessica K., Bixby, John L., Lemmon, Vance P.

“…Axon regeneration is a fundamental problem facing neuroscientists and clinicians. Failure of axon regeneration is caused by both extrinsic and intrinsic…”
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Glucocorticoids and macrophage migration inhibitory factor (MIF) are neuroendocrine modulators of inflammation and neuropathic pain after spinal cord injury by Lerch, Jessica K, Puga, Denise A, Bloom, Ona, Popovich, Phillip G

“…Highlights • Stress hormones and inflammatory mediators affect functional recovery after spinal cord injury. • After spinal cord injury the…”
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