Search Results - "Leppla, S H"

Phosphatidylcholine-Specific Phospholipase C and Sphingomyelinase Activities in Bacteria of the Bacillus cereus Group by POMERANTSEV, A. P, KALNIN, K. V, OSORIO, M, LEPPLA, S. H

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Cytolethal distending toxin B as a cell-killing component of tumor-targeted anthrax toxin fusion proteins by Bachran, C, Hasikova, R, Leysath, C E, Sastalla, I, Zhang, Y, Fattah, R J, Liu, S, Leppla, S H

“…Cytolethal distending toxin (Cdt) is produced by Gram-negative bacteria of several species. It is composed of three subunits, CdtA, CdtB, and CdtC, with CdtB…”
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Crystal structure of the anthrax toxin protective antigen by Petosa, Carlo, Collier, R. John, Klimpel, Kurt R, Leppla, Stephen H, Liddington, Robert C

“…Protective antigen (PA) is the central component of the three-part protein toxin secreted by Bacillus anthracis, the organism responsible for anthrax. After…”
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Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor by Duesbery, Nicholas S., Webb, Craig P., Leppla, Stephen H., Gordon, Valery M., Klimpel, Kurt R., Copeland, Terry D., Ahn, Natalie G., Oskarsson, Marianne K., Fukasawa, Kenji, Paull, Ken D., George F. Vande Woude

“…Anthrax lethal toxin, produced by the bacterium Bacillus anthracis, is the major cause of death in animals infected with anthrax. One component of this toxin,…”
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Production, recovery and immunogenicity of the protective antigen from a recombinant strain of Bacillus anthracis by Ramirez, D.M, Leppla, S.H, Schneerson, R, Shiloach, J

“…The protective antigen (PA) is one of the three components of the anthrax toxin. It is a secreted nontoxic protein with a molecular weight of 83 kDa and is the…”
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Suppression of Ras-Mediated Transformation and Inhibition of Tumor Growth and Angiogenesis by Anthrax Lethal Factor, a Proteolytic Inhibitor of Multiple MEK Pathways by Duesbery, N. S., Resau, J., Webb, C. P., Koochekpour, S., H.-M. Koo, Leppla, S. H., G. F. Vande Woude

“…Lethal factor is a protease, one component of Bacillus anthracis exotoxin, which cleaves many of the mitogen-activated protein kinase kinases (MEKs). Given the…”
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Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases by GORDON, V. M, KLIMPEL, K. R, ARORA, N, HENDERSON, M. A, LEPPLA, S. H

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Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen by MOLLOY, S. S, BRESNAHAN, P. A, LEPPLA, S. H, KLIMPEL, K. R, THOMAS, G

“…Previous work demonstrated that human furin is a predominantly Golgi membrane-localized endoprotease that can efficiently process precursor proteins at paired…”
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Anthrax Toxin Protective Antigen is Activated by a Cell Surface Protease with the Sequence Specificity and Catalytic Properties of Furin by Klimpel, Kurt R., Molloy, Sean S., Thomas, Gary, Leppla, Stephen H.

“…Proteolytic cleavage of the protective antigen (PA) protein of anthrax toxin at residues 164-167 is necessary for toxic activity. Cleavage by a cellular…”
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Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin by SHIHUI LIU, NETZEL-ARNETT, Sarah, BIRKEDAL-HANSEN, Henning, LEPPLA, Stephen H

“…Matrix metalloproteinases (MMPs) are overexpressed in a variety of tumor tissues and cell lines, and their expression is highly correlated to tumor invasion…”
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Protection against Anthrax Lethal Toxin Challenge by Genetic Immunization with a Plasmid Encoding the Lethal Factor Protein by PRICE, Brian M, LINER, Adriane L, SUKJOON PARK, LEPPLA, Stephen H, MATECZUN, Alfred, GALLOWAY, Darrell R

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Fusions of anthrax toxin lethal factor with shiga toxin and diphtheria toxin enzymatic domains are toxic to mammalian cells by ARORA, N, LEPPLA, S. H

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Proteasome Activity Is Required for Anthrax Lethal Toxin To Kill Macrophages by Tang, G, Leppla, S H

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Residues 1-254 of anthrax toxin lethal factor are sufficient to cause cellular uptake of fused polypeptides by Arora, N, Leppla, S.H

“…Anthrax lethal toxin is a complex of protective antigen (PA, 735 amino acids) and lethal factor (LF, 776 amino acids) that lyses certain eukaryotic cells. LF…”
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Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity by Klimpel, K R, Arora, N, Leppla, S H

“…Comparison of the anthrax toxin lethal factor (LF) amino acid sequence with sequences in the Swiss protein database revealed short regions of similarity with…”
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Proteolytic activation of bacterial toxins : role of bacterial and host cell proteases by GORDON, V. M, LEPPLA, S. H

“…A number of eukaryotic proteases are active in extracellular spaces under certain circumstances (plasmin during blood clotting, neutrophil elastase during…”
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Cloning and characterization of a gene whose product is a trans-activator of anthrax toxin synthesis by Uchida, I, Hornung, J.M, Thorne, C.B, Klimpel, K.R, Leppla, S.H

“…The 184-kb Bacillus anthracis plasmid pXO1, which is required for virulence, contains three genes encoding the protein components of anthrax toxin, cya (edema…”
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Clostridium septicum alpha-toxin is proteolytically activated by furin by GORDON, V. M, BENZ, R, FUJII, K, LEPPLA, S. H, TWETEN, R. K

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Oligomerization of Anthrax Toxin Protective Antigen and Binding of Lethal Factor during Endocytic Uptake into Mammalian Cells by SINGH, Y, KLIMPEL, K. R, GOEL, S, SWAIN, P. K, LEPPLA, S. H

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Characterization of macrophage sensitivity and resistance to anthrax lethal toxin by FRIEDLANDER, A. M, BHATNAGAR, R, LEPPLA, S. H, JOHNSON, L, SINGH, Y

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