Search Results - "Leppik, IE"

Zonisamide by Leppik, Ilo E.

“…Zonisamide (ZNS) is a broad‐spectrum antiepileptic drug in both animal models of epilepsy and patients with epilepsy. It is effective for both…”
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Tiagabine: the safety landscape by Leppik, I E

“…Tiagabine (TGB) hydrochloride is a potential new antiepileptic drug (AED) undergoing clinical development. Experience in humans amounts to 1,810 patient-years…”
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Felbamate by Leppik, I E

“…After the first year of clinical experience, felbamate (FBM) appears to be a valuable antiepileptic drug (AED) for the treatment of intractable epilepsy…”
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Zonisamide: chemistry, mechanism of action, and pharmacokinetics by Leppik, Ilo E.

“…Zonisamide is a synthetic 1,2-benzisoxazole-3-methanesulfonamide with anticonvulsant properties. The sulfamoyl group on zonisamide was expected to suppress…”
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Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies by Patsalos, Philip N., Berry, David J., Bourgeois, Blaise F. D., Cloyd, James C., Glauser, Tracy A., Johannessen, Svein I., Leppik, Ilo E., Tomson, Torbjörn, Perucca, Emilio

“…Summary Although no randomized studies have demonstrated a positive impact of therapeutic drug monitoring (TDM) on clinical outcome in epilepsy, evidence from…”
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Hyponatremia from oxcarbazepine and carbamazepine by Dong, Xiaoming, Leppik, Ilo E, White, James, Rarick, John

“…The authors examined sodium concentrations from 97 oxcarbazepine-treated (OXC) and 451 carbamazepine-treated (CBZ) patients with epilepsy using cross-section…”
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Compliance during treatment of epilepsy by Leppik, I E

“…Noncompliance is a major factor in suboptimal control of epileptic seizures. As many as one-third to one-half of persons with epilepsy may be noncompliant…”
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Epilepsy in the Elderly by Leppik, Ilo E.

“…The elderly are the most rapidly growing segment of the population and the incidence of epilepsy is higher in the elderly than in any other age group. They…”
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Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures by FAUGHT, E, AYALA, R, MONTOURIS, G. G, LEPPIK, I. E

“…Zonisamide is a sulfonamide antiepilepsy drug with sodium and calcium channel-blocking actions. Experience in Japan and a previous European double-blind study…”
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Incidence and risk factors in sudden unexpected death in epilepsy : A prospective cohort study by WALCZAK, T. S, LEPPIK, I. E, D'AMELIO, M, RARICK, J, SO, E, AHMAN, P, RUGGLES, K, CASCINO, G. D, ANNEGERS, J. F, HAUSER, W. A

“…To determine incidence of and risk factors for sudden unexpected death in epilepsy (SUDEP). Three epilepsy centers enrolled 4,578 patients and prospectively…”
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Lamotrigine clearance during pregnancy by TRAN, T. A, LEPPIK, I. E, BLESI, K, SATHANANDAN, S. T, REMMEL, R

“…To evaluate changes in lamotrigine (LTG) clearance before, during, and after pregnancy. Twelve pregnancies that had complete steady-state data before, during,…”
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Discontinuation of levetiracetam because of behavioral side effects a case-control study by WHITE, J. R, WALCZAK, T. S, LEPPIK, I. E, RARICK, J, TRAN, T, BENIAK, T. E, MATCHINSKY, D. J, GUMNIT, R. J

“…Levetiracetam (LEV) is a recently approved anticonvulsant with proven efficacy and safety in the treatment of partial seizures. LEV may cause behavioral…”
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Practical prescribing and long-term efficacy and safety of zonisamide by Leppik, Ilo E.

“…Long-term efficacy, tolerability and safety of antiepileptic drug (AED) therapy is essential given the chronic nature of epilepsy. Zonisamide (Zonegran ®), a…”
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Introduction to the International Geriatric Epilepsy Symposium (IGES) by Leppik, Ilo E.

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Lower phenytoin serum levels in persons switched from brand to generic phenytoin by BURKHARDT, R. T, LEPPIK, I. E, BLESI, K, SCOTT, S, GAPANY, S. R, CLOYD, J. C

“…After generic phenytoin (PHT) was marketed, the authors identified eight adult patients (ages 34 to 49) whose seizures increased enough to require intervention…”
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Antiepileptic drug use in nursing home admissions by Garrard, Judith, Harms, Susan, Hardie, Nancy, Eberly, Lynn E., Nitz, Nicole, Bland, Patricia, Gross, Cynthia R., Leppik, Ilo E.

“…Although 1 of 10 nursing home residents is taking an antiepileptic drug (AED), no study to our knowledge has determined whether most residents are already…”
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Variability of total phenytoin serum concentrations within elderly nursing home residents by BIRNBAUM, A, HARDIE, N. A, LEPPIK, I. E, CONWAY, J. M, BOWERS, S. E, LACKNER, T, GRAVES, N. M

“…Approximately 6% of all elderly nursing home residents receive phenytoin. Phenytoin concentrations are often measured to guide therapy. To evaluate the…”
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Steady-state Carbamazepine Pharmacokinetics following Oral and Stable-Labeled Intravenous Administration in Epilepsy Patients: Effect of Race and Sex by Marino, SE, Birnbaum, AK, Leppik, IE, Conway, JM, Musib, LC, Brundage, RC, Ramsay, RE, Pennell, PB, White, JR, Gross, CR, Rarick, JO, Mishra, U, Cloyd, JC

“…Carbamazepine is a widely prescribed antiepileptic drug. Due to a lack of an intravenous formulation, its absolute bioavailability, absolute clearance, and…”
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The place of levetiracetam in the treatment of epilepsy by Leppik, I E

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Classification of the Myoclonic Epilepsies by Leppik, Ilo E.

“…The myoclonic epilepsies are a collection of syndromes in which myoclonic seizures are a prominent feature. Proper classification of a patient's syndrome is…”
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