Search Results - "Leppek, Kathrin"

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics by Leppek, Kathrin, Byeon, Gun Woo, Kladwang, Wipapat, Wayment-Steele, Hannah K., Kerr, Craig H., Xu, Adele F., Kim, Do Soon, Topkar, Ved V., Choe, Christian, Rothschild, Daphna, Tiu, Gerald C., Wellington-Oguri, Roger, Fujii, Kotaro, Sharma, Eesha, Watkins, Andrew M., Nicol, John J., Romano, Jonathan, Tunguz, Bojan, Diaz, Fernando, Cai, Hui, Guo, Pengbo, Wu, Jiewei, Meng, Fanyu, Shi, Shuai, Participants, Eterna, Dormitzer, Philip R., Solórzano, Alicia, Barna, Maria, Das, Rhiju

“…Therapeutic mRNAs and vaccines are being developed for a broad range of human diseases, including COVID-19. However, their optimization is hindered by mRNA…”
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The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity by Simsek, Deniz, Tiu, Gerald C., Flynn, Ryan A., Byeon, Gun W., Leppek, Kathrin, Xu, Adele F., Chang, Howard Y., Barna, Maria

“…During eukaryotic evolution, ribosomes have considerably increased in size, forming a surface-exposed ribosomal RNA (rRNA) shell of unknown function, which may…”
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Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs by Leppek, Kathrin, Schott, Johanna, Reitter, Sonja, Poetz, Fabian, Hammond, Ming C., Stoecklin, Georg

“…Tumor necrosis factor-α (TNF-α) is the most potent proinflammatory cytokine in mammals. The degradation of TNF-α mRNA is critical for restricting TNF-α…”
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Gene- and Species-Specific Hox mRNA Translation by Ribosome Expansion Segments by Leppek, Kathrin, Fujii, Kotaro, Quade, Nick, Susanto, Teodorus Theo, Boehringer, Daniel, Lenarčič, Tea, Xue, Shifeng, Genuth, Naomi R., Ban, Nenad, Barna, Maria

“…Ribosomes have been suggested to directly control gene regulation, but regulatory roles for ribosomal RNA (rRNA) remain largely unexplored. Expansion segments…”
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An rRNA variant to deal with stress by Leppek, Kathrin, Barna, Maria

“…Bacteria have previously been assumed to cope with environmental stress by tuning their total number of active ribosomes. Instead, a study in this issue of…”
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Genome-wide assessment of AU-rich elements by the AREScore algorithm by Spasic, Milan, Friedel, Caroline C, Schott, Johanna, Kreth, Jochen, Leppek, Kathrin, Hofmann, Sarah, Ozgur, Sevim, Stoecklin, Georg

“…In mammalian cells, AU-rich elements (AREs) are well known regulatory sequences located in the 3' untranslated region (UTR) of many short-lived mRNAs. AREs…”
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A Distinct, Sequence-Induced Conformation Is Required for Recognition of the Constitutive Decay Element RNA by Roquin by Codutti, Luca, Leppek, Kathrin, Zálešák, Jan, Windeisen, Volker, Masiewicz, Pawel, Stoecklin, Georg, Carlomagno, Teresa

“…The constitutive decay element (CDE) of tumor necrosis factor α (TNF-α) mRNA (Tnf) represents the prototype of a class of RNA motifs that mediate rapid…”
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Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them by Leppek, Kathrin, Das, Rhiju, Barna, Maria

“…Key Points mRNA 5′ untranslated regions (UTRs), which serve as the entry point for the ribosome during translation, can adopt elaborate RNA secondary and…”
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An optimized streptavidin-binding RNA aptamer for purification of ribonucleoprotein complexes identifies novel ARE-binding proteins by Leppek, Kathrin, Stoecklin, Georg

“…Determining the composition of messenger ribonucleoprotein (mRNP) particles is essential for a comprehensive understanding of the complex mechanisms underlying…”
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Author Correction: Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them by Leppek, Kathrin, Das, Rhiju, Barna, Maria

“…The legend of Figure 1 has been modified to remove misleading referencing to evolution. The title of the legend has been modified from ‘Evolutionary expansion…”
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VELCRO-IP RNA-seq reveals ribosome expansion segment function in translation genome-wide by Leppek, Kathrin, Byeon, Gun Woo, Fujii, Kotaro, Barna, Maria

“…Roles for ribosomal RNA (rRNA) in gene regulation remain largely unexplored. With hundreds of rDNA units positioned across multiple loci, it is not possible to…”
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Protein synthesis and translational control: at eye level with the ribosome by Leppek, Kathrin, Schott, Johanna, Stoecklin, Georg

“…At the EMBO Conference on ‘Protein Synthesis and Translational Control’ held in Heidelberg in September 2011, scientists shared their latest findings on the…”
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