Search Results - "Leppä, Sirpa"

Immune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma by Autio, Matias, Leivonen, Suvi-Katri, Brück, Oscar, Mustjoki, Satu, Mészáros Jørgensen, Judit, Karjalainen-Lindsberg, Marja-Liisa, Beiske, Klaus, Holte, Harald, Pellinen, Teijo, Leppä, Sirpa

“…The tumor microenvironment (TME) and limited immune surveillance play important roles in lymphoma pathogenesis. Here we aimed to characterize immunological…”
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Phosphatidylinositol 3-Kinase Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma by Dreyling, Martin, Santoro, Armando, Mollica, Luigina, Leppä, Sirpa, Follows, George A, Lenz, Georg, Kim, Won Seog, Nagler, Arnon, Panayiotidis, Panayiotis, Demeter, Judit, Özcan, Muhit, Kosinova, Marina, Bouabdallah, Krimo, Morschhauser, Franck, Stevens, Don A, Trevarthen, David, Giurescu, Marius, Cupit, Lisa, Liu, Li, Köchert, Karl, Seidel, Henrik, Peña, Carol, Yin, Shuxin, Hiemeyer, Florian, Garcia-Vargas, Jose, Childs, Barrett H, Zinzani, Pier Luigi

“…Purpose Phosphatidylinositol 3-kinase (PI3K) signaling is critical for the proliferation and survival of malignant B cells. Copanlisib, a pan-class I PI3K…”
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Blood has never been thicker: Cell-free DNA fragmentomics in the liquid biopsy toolbox of B-cell lymphomas by Meriranta, Leo, Pitkänen, Esa, Leppä, Sirpa

“…Liquid biopsies utilizing plasma circulating tumor DNA (ctDNA) are anticipated to revolutionize decision-making in cancer care. In the field of lymphomas,…”
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Ofatumumab Versus Rituximab Salvage Chemoimmunotherapy in Relapsed or Refractory Diffuse Large B-Cell Lymphoma: The ORCHARRD Study by van Imhoff, Gustaaf W, McMillan, Andrew, Matasar, Matthew J, Radford, John, Ardeshna, Kirit M, Kuliczkowski, Kazimierz, Kim, WonSeog, Hong, Xiaonan, Goerloev, Jette Soenderskov, Davies, Andrew, Barrigón, María Dolores Caballero, Ogura, Michinori, Leppä, Sirpa, Fennessy, Michael, Liao, Qiming, van der Holt, Bronno, Lisby, Steen, Hagenbeek, Anton

“…Purpose We compared the efficacy of ofatumumab (O) versus rituximab (R) in combination with cisplatin, cytarabine, and dexamethasone (DHAP) salvage treatment,…”
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Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Non-Germinal Center B-Cell Diffuse Large B-Cell Lymphoma by Younes, Anas, Sehn, Laurie H, Johnson, Peter, Zinzani, Pier Luigi, Hong, Xiaonan, Zhu, Jun, Patti, Caterina, Belada, David, Samoilova, Olga, Suh, Cheolwon, Leppä, Sirpa, Rai, Shinya, Turgut, Mehmet, Jurczak, Wojciech, Cheung, Matthew C, Gurion, Ronit, Yeh, Su-Peng, Lopez-Hernandez, Andres, Dührsen, Ulrich, Thieblemont, Catherine, Chiattone, Carlos Sergio, Balasubramanian, Sriram, Carey, Jodi, Liu, Grace, Shreeve, S Martin, Sun, Steven, Zhuang, Sen Hong, Vermeulen, Jessica, Staudt, Louis M, Wilson, Wyndham

“…Ibrutinib has shown activity in non-germinal center B-cell diffuse large B-cell lymphoma (DLBCL). This double-blind phase III study evaluated ibrutinib and…”
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Serum protein profiling reveals an inflammation signature as a predictor of early breast cancer survival by Karihtala, Peeter, Leivonen, Suvi-Katri, Puistola, Ulla, Urpilainen, Elina, Jääskeläinen, Anniina, Leppä, Sirpa, Jukkola, Arja

“…Breast cancers exhibit considerable heterogeneity in their biology, immunology, and prognosis. Currently, no validated, serum protein-based tools are available…”
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Clinical Impact of Immune Cells and Their Spatial Interactions in Diffuse Large B-Cell Lymphoma Microenvironment by Autio, Matias, Leivonen, Suvi-Katri, Brück, Oscar, Karjalainen-Lindsberg, Marja-Liisa, Pellinen, Teijo, Leppä, Sirpa

“…Tumor-infiltrating immune cells have prognostic significance and are attractive therapeutic targets. Yet, the clinical significance of their spatial…”
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Transformation and survival in marginal zone lymphoma: a Finnish nationwide population-based study by Kalashnikov, Ilja, Tanskanen, Tomas, Viisanen, Leevi, Malila, Nea, Jyrkkiö, Sirkku, Leppä, Sirpa

“…Marginal zone lymphoma (MZL) is an indolent B-cell malignancy with heterogeneous anatomical and clinical presentation. While MZLs are generally associated with…”
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PD-L1 + tumor-associated macrophages and PD-1 + tumor-infiltrating lymphocytes predict survival in primary testicular lymphoma by Pollari, Marjukka, Brück, Oscar, Pellinen, Teijo, Vähämurto, Pauli, Karjalainen-Lindsberg, Marja-Liisa, Mannisto, Susanna, Kallioniemi, Olli, Kellokumpu-Lehtinen, Pirkko-Liisa, Mustjoki, Satu, Leivonen, Suvi-Katri, Leppä, Sirpa

“…Primary testicular lymphoma is a rare and aggressive lymphoid malignancy, most often representing diffuse large B-cell lymphoma histologically…”
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Randomized, Double-Blind, Phase III Trial of Enzastaurin Versus Placebo in Patients Achieving Remission After First-Line Therapy for High-Risk Diffuse Large B-Cell Lymphoma by Crump, Michael, Leppä, Sirpa, Fayad, Luis, Lee, Je Jung, Di Rocco, Alice, Ogura, Michinori, Hagberg, Hans, Schnell, Frederick, Rifkin, Robert, Mackensen, Andreas, Offner, Fritz, Pinter-Brown, Lauren, Smith, Sonali, Tobinai, Kensei, Yeh, Su-Peng, Hsi, Eric D, Nguyen, Tuan, Shi, Peipei, Hahka-Kemppinen, Marjo, Thornton, Don, Lin, Boris, Kahl, Brad, Schmitz, Norbert, Savage, Kerry J, Habermann, Thomas

“…To compare disease-free survival (DFS) after maintenance therapy with the selective protein kinase C β (PKCβ) inhibitor, enzastaurin, versus placebo in…”
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Distinct subtypes of diffuse large B-cell lymphoma defined by hypermutated genes by Alkodsi, Amjad, Cervera, Alejandra, Zhang, Kaiyang, Louhimo, Riku, Meriranta, Leo, Pasanen, Annika, Leivonen, Suvi-Katri, Holte, Harald, Leppä, Sirpa, Lehtonen, Rainer, Hautaniemi, Sampsa

“…Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous disease whose personalized clinical management requires robust molecular…”
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Prognostic influence of macrophages in patients with diffuse large B-cell lymphoma: a correlative study from a Nordic phase II trial by Riihijärvi, Sari, Fiskvik, Idun, Taskinen, Minna, Vajavaara, Heli, Tikkala, Maria, Yri, Olav, Karjalainen-Lindsberg, Marja-Liisa, Delabie, Jan, Smeland, Erlend, Holte, Harald, Leppä, Sirpa

“…The prognostic impact of the tumor microenvironment in diffuse large B-cell lymphoma has not been systematically assessed. We analyzed mRNA and antigen…”
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T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma by Leivonen, Suvi-Katri, Pollari, Marjukka, Brück, Oscar, Pellinen, Teijo, Autio, Matias, Karjalainen-Lindsberg, Marja-Liisa, Mannisto, Susanna, Kellokumpu-Lehtinen, Pirkko-Liisa, Kallioniemi, Olli, Mustjoki, Satu, Leppä, Sirpa

“…Primary testicular lymphoma is a rare lymphoid malignancy, most often, histologically, representing diffuse large B-cell lymphoma. The tumor microenvironment…”
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FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders by Lehtonen, Jenni M, Forsström, Saara, Bottani, Emanuela, Viscomi, Carlo, Baris, Olivier R, Isoniemi, Helena, Höckerstedt, Krister, Österlund, Pia, Hurme, Mikko, Jylhävä, Juulia, Leppä, Sirpa, Markkula, Ritva, Heliö, Tiina, Mombelli, Giuliana, Uusimaa, Johanna, Laaksonen, Reijo, Laaksovirta, Hannu, Auranen, Mari, Zeviani, Massimo, Smeitink, Jan, Wiesner, Rudolf J, Nakada, Kazuto, Isohanni, Pirjo, Suomalainen, Anu

“…OBJECTIVE:To validate new mitochondrial myopathy serum biomarkers for diagnostic use. METHODS:We analyzed serum FGF21 (S-FGF21) and GDF15 from patients with…”
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A High Tumor-Associated Macrophage Content Predicts Favorable Outcome in Follicular Lymphoma Patients Treated with Rituximab and Cyclophosphamide-Doxorubicin-Vincristine-Prednisone by TASKINEN, Minna, KARJALAINEN -LINDSBERG, Marja-Liisa, NYMAN, Heidi, EEROLA, Leena-Maija, LEPPÄ, Sirpa

“…Purpose: Tumor-associated macrophage (TAM) content predicts survival in follicular lymphoma (FL) patients treated with chemotherapy. The aim of this study was…”
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Molecular features encoded in the ctDNA reveal heterogeneity and predict outcome in high-risk aggressive B-cell lymphoma by Meriranta, Leo, Alkodsi, Amjad, Pasanen, Annika, Lepistö, Maija, Mapar, Parisa, Blaker, Yngvild Nuvin, Jørgensen, Judit, Karjalainen-Lindsberg, Marja-Liisa, Fiskvik, Idun, Mikalsen, Lars Tore G., Autio, Matias, Björkholm, Magnus, Jerkeman, Mats, Fluge, Øystein, Brown, Peter, Jyrkkiö, Sirkku, Holte, Harald, Pitkänen, Esa, Ellonen, Pekka, Leppä, Sirpa

“…Inadequate molecular and clinical stratification of the patients with high-risk diffuse large B-cell lymphoma (DLBCL) is a clinical challenge hampering the…”
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Characterization and clinical impact of the tumor microenvironment in post-transplant aggressive B-cell lymphomas by Leivonen, Suvi-Katri, Friman, Terhi, Autio, Matias, Vaittinen, Samuli, Jensen, Andreas Wind, D'Amore, Francesco, Hamilton-Dutoit, Stephen Jacques, Holte, Harald, Beiske, Klaus, Kovanen, Panu E, Räty, Riikka, Leppä, Sirpa

“…Post-transplant lymphoproliferative disorders (PTLDs) are iatrogenic immune deficiencyassociated lymphoid/plasmacytic proliferations developing due to…”
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Successful change of treatment strategy in elderly patients with primary central nervous system lymphoma by de-escalating induction and introducing temozolomide maintenance: results from a phase II study by the Nordic Lymphoma Group by Pulczynski, Elisa J, Kuittinen, Outi, Erlanson, Martin, Hagberg, Hans, Fosså, Alexander, Eriksson, Mikael, Nordstrøm, Marie, Østenstad, Bjørn, Fluge, Øystein, Leppä, Sirpa, Fiirgaard, Bente, Bersvendsen, Hanne, Fagerli, Unn-Merete

“…The Nordic Lymphoma Group has conducted a phase ll trial in newly diagnosed primary central nervous system lymphoma patients applying an age-adjusted…”
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Testicular Diffuse Large B-Cell Lymphoma—Clinical, Molecular, and Immunological Features by Pollari, Marjukka, Leivonen, Suvi-Katri, Leppä, Sirpa

“…Primary testicular lymphoma is a rare lymphoma entity, yet it is the most common testicular malignancy among elderly men. The majority of the cases represent…”
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Prognostic Impact of Tumor-Associated Macrophages on Survival Is Checkpoint Dependent in Classical Hodgkin Lymphoma by Karihtala, Kristiina, Leivonen, Suvi-Katri, Brück, Oscar, Karjalainen-Lindsberg, Marja-Liisa, Mustjoki, Satu, Pellinen, Teijo, Leppä, Sirpa

“…Tumor microenvironment and immune escape affect pathogenesis and survival in classical Hodgkin lymphoma (cHL). While tumor-associated macrophage (TAM) content…”
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