Search Results - "Leppä, M."

Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks by Ruzzo, Elizabeth K., Pérez-Cano, Laura, Jung, Jae-Yoon, Wang, Lee-kai, Kashef-Haghighi, Dorna, Hartl, Chris, Singh, Chanpreet, Xu, Jin, Hoekstra, Jackson N., Leventhal, Olivia, Leppä, Virpi M., Gandal, Michael J., Paskov, Kelley, Stockham, Nate, Polioudakis, Damon, Lowe, Jennifer K., Prober, David A., Geschwind, Daniel H., Wall, Dennis P.

“…We performed a comprehensive assessment of rare inherited variation in autism spectrum disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals…”
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Structural Features of Hydrolyzable Tannins Determine Their Ability to Form Insoluble Complexes with Bovine Serum Albumin by Engström, M. T, Arvola, J, Nenonen, S, Virtanen, V. T. J, Leppä, M. M, Tähtinen, P, Salminen, J. -P

“…The ability of 32 purified and characterized hydrolyzable tannins to form insoluble complexes with model protein bovine serum albumin was investigated with a…”
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Isolation of chemically well-defined semipreparative liquid chromatography fractions from complex mixtures of proanthocyanidin oligomers and polymers by Leppä, Milla M., Karonen, Maarit, Tähtinen, Petri, Engström, Marica T., Salminen, Juha-Pekka

“…•Tens of different tannin fractions were produced from a single plant sample.•New tannin fractions differed significantly from the original sample.•Tannin…”
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Correction to Structural Features of Hydrolyzable Tannins Determine Their Ability to Form Insoluble Complexes with Bovine Serum Albumin by Engström, M. T, Arvola, J, Nenonen, S, Virtanen, V. T. J, Leppä, M. M, Tähtinen, P, Salminen, J.-P

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Gut microbiota-mediated polyphenol metabolism is restrained by parasitic whipworm infection and associated with altered immune function in mice by Schytz Andersen-Civil, Audrey Inge, Arora, Pankaj, Zhu, Ling, Myhill, Laura J, Büdeyri Gökgöz, Nilay, Castro-Mejia, Josue L, Leppä, Milla M, Hansen, Lars H, Lessard-Lord, Jacob, Salminen, Juha-Pekka, Thamsborg, Stig M, Sandris Nielsen, Dennis, Desjardins, Yves, Williams, Andrew R

“…Polyphenols are phytochemicals commonly found in plant-based diets which have demonstrated immunomodulatory and anti-inflammatory properties. However, the…”
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Simple variables predict miserable outcome after intravenous thrombolysis by Seiffge, D. J., Karagiannis, A., Strbian, D., Gensicke, H., Peters, N., Bonati, L. H., Kotisaari, K., Leppä, M., Kejda-Scharler, J., Tränka, C., Ginsbach, P., Tatlisumak, T., Lyrer, P. A., Engelter, S. T.

“…Background and purpose To test the predictability of miserable outcome amongst ischaemic stroke patients receiving intravenous thrombolysis (IVT) based on a…”
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S123: DECODING TRANSCRIPTOMIC AND EPIGENETIC CONSEQUENCES OF STRUCTURAL VARIANTS IN CK‐AML AT SINGLE‐CELL RESOLUTION by Leppä, A.‐M., Grimes, K., Jeong, H., Boch, T., Karpova, D, Jauch, A., Grünschläger, F., Dolnik, A., Bullinger, L., Krämer, A., Sanders, A. D., Korbel, J. O., Trumpp, A.

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P447: BCL2‐INHIBITION TARGETS LEUKEMIC STEM CELLS IN ACUTE MYELOID LEUKEMIA INDEPENDENT OF MONOCYTIC BLAST POPULATIONS by Renders, S., Leppä, A.‐M., Waclawiczek, A., Reyneri, C., Janssen, M., Donato, E., Unglaub, J., Pabst, C., Schlenk, R., Hundemer, M., Raffel, S., Sauer, T., Müller‐Tidow, C., Trumpp, A.

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Fermentation quality of ensiled crimped faba beans using different additives with special attention to changes in bioactive compounds by Rinne, Marketta, Leppä, Milla M., Kuoppala, Kaisa, Koivunen, Erja, Kahala, Minna, Jalava, Taina, Salminen, Juha-Pekka, Manni, Katariina

“…•Fermentation quality of moist crimped faba beans improved using silage additives.•Silage additives also improved the aerobic stability of crimped faba…”
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Genome-wide copy number variation association study in anorexia nervosa by Walker, Alicia, Karlsson, Robert, Szatkiewicz, Jin P., Thornton, Laura M., Yilmaz, Zeynep, Leppä, Virpi M., Savva, Androula, Lin, Tian, Sidorenko, Julia, McRae, Allan, Kirov, George, Davies, Helena L., Fundín, Bengt T., Chawner, Samuel J. R. A., Song, Jie, Borg, Stina, Wen, Jia, Watson, Hunna J., Munn-Chernoff, Melissa A., Baker, Jessica H., Gordon, Scott, Berrettini, Wade H., Brandt, Harry, Crawford, Steven, Halmi, Katherine A., Kaplan, Allan S., Kaye, Walter H., Mitchell, James, Strober, Michael, Woodside, D. Blake, Pedersen, Nancy L., Parker, Richard, Jordan, Jennifer, Kennedy, Martin A., Birgegård, Andreas, Landén, Mikael, Martin, Nicholas G., Sullivan, Patrick F., Bulik, Cynthia M., Wray, Naomi R.

“…This study represents the first large-scale investigation of rare (<1% population frequency) copy number variants (CNVs) in anorexia nervosa (AN). Large, rare…”
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Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex Families by Leppa, Virpi M., Kravitz, Stephanie N., Martin, Christa Lese, Andrieux, Joris, Le Caignec, Cedric, Martin-Coignard, Dominique, DyBuncio, Christina, Sanders, Stephan J., Lowe, Jennifer K., Cantor, Rita M., Geschwind, Daniel H.

“…Rare mutations, including copy-number variants (CNVs), contribute significantly to autism spectrum disorder (ASD) risk. Although their importance has been…”
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S120: ACUTE MYELOID LEUKEMIA REPRESENTS A FERROPTOSIS-SENSITIVE CANCER ENTITY RAISING THE POSSIBILITY FOR NOVEL TARGETING STRATEGIES by Narr, A., Alborzinia, H., Donato, E., Vogel, F., Boch, T., Leppä, A.-M., Waclawiczek, A., Renders, S., Schulze, A., Trumpp, A.

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Individual and population-level food consumption by cyprinids and percids in a mesotrophic lake by Tolonen, K. T., Karjalainen, J., Staff, S., Leppä, M.

“…– Mesotrophic Lake Pohjalampi in eastern Finland was fished intensively from 1992 to 1996. In 1996, the biomasses of the dominant fish species, roach and…”
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Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa by Hübel, Christopher, Bryois, Julien, Hinney, Anke, Leppä, Virpi M., Mattheisen, Manuel, Medland, Sarah E., Giusti-Rodríguez, Paola, Alfredsson, Lars, Berrettini, Wade H., Boni, Claudette, Burghardt, Roland, Cichon, Sven, Cone, Roger D., Courtet, Philippe, Crowley, James J., Davis, Oliver S. P., de Zwaan, Martina, Dikeos, Dimitris, Dina, Christian, Duncan, Laramie E., Egberts, Karin, Estivill, Xavier, Favaro, Angela, Fernández-Aranda, Fernando, Fichter, Manfred M., Forstner, Andreas J., Forzan, Monica, Franklin, Christopher S., Giegling, Ina, Guillaume, Sébastien, Hakonarson, Hakon, Hatzikotoulas, Konstantinos, Hauser, Joanna, Helder, Sietske G., Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Huckins, Laura M., Hudson, James I., Inoko, Hidetoshi, Janout, Vladimir, Julià, Antonio, Kalsi, Gursharan, Kaminská, Deborah, Karhunen, Leila, Keski-Rahkonen, Anna, Kim, Youl-Ri, Knudsen, Gun Peggy S., La Via, Maria C., Levitan, Robert D., Lin, Bochao Danae, Luykx, Jurjen, Marsal, Sara, Marshall, Christian R., McDevitt, Sara, McGuffin, Peter, Metspalu, Andres, Monteleone, Alessio Maria, Monteleone, Palmiero, Munn-Chernoff, Melissa A., Navratilova, Marie, O’Toole, Julie K., Palotie, Aarno, Raevuori, Anu, Ramoz, Nicolas, Reichborn-Kjennerud, Ted, Ritschel, Franziska, Roberts, Marion, Rotondo, Alessandro, Rujescu, Dan, Rybakowski, Filip, Santonastaso, Paolo, Scherer, Stephen W., Schmidt, Ulrike, Schosser, Alexandra, Slagboom, P. Eline, Sorbi, Sandro, Szatkiewicz, Jin P., Tenconi, Elena, Tortorella, Alfonso, Treasure, Janet, Tziouvas, Konstantinos, van Elburg, Annemarie A., van Furth, Eric F., Zipfel, Stephan, Bergen, Andrew W., Boden, Joseph M., Johnson, Craig, Kaye, Walter H., Mitchell, James E., Olsen, Catherine M., Woodside, D. Blake, Stuber, Garret D., Gordon, Scott, Henders, Anjali K., Juréus, Anders, Petersen, Liselotte, Wade, Tracey D., Landén, Mikael, Sullivan, Patrick F., Breen, Gerome

“…Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness 1 , affecting 0.9–4% of women and 0.3% of men 2 – 4 , with…”
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The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods by Thornton, Laura M., Munn-Chernoff, Melissa A., Baker, Jessica H., Juréus, Anders, Parker, Richard, Henders, Anjali K., Larsen, Janne T., Petersen, Liselotte, Watson, Hunna J., Yilmaz, Zeynep, Kirk, Katherine M., Gordon, Scott, Leppä, Virpi M., Martin, Felicity C., Whiteman, David C., Olsen, Catherine M., Werge, Thomas M., Pedersen, Nancy L., Kaye, Walter, Bergen, Andrew W., Halmi, Katherine A., Strober, Michael, Kaplan, Allan S., Woodside, D. Blake, Mitchell, James, Johnson, Craig L., Brandt, Harry, Crawford, Steven, Horwood, L. John, Boden, Joseph M., Pearson, John F., Duncan, Laramie E., Grove, Jakob, Mattheisen, Manuel, Jordan, Jennifer, Kennedy, Martin A., Birgegård, Andreas, Lichtenstein, Paul, Norring, Claes, Wade, Tracey D., Montgomery, Grant W., Martin, Nicholas G., Landén, Mikael, Mortensen, Preben Bo, Sullivan, Patrick F., Bulik, Cynthia M.

“…Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for…”
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Multi-parametric single cell evaluation defines distinct drug responses in healthy hematologic cells that are retained in corresponding malignant cell types by Majumder, Muntasir M, Leppä, Aino-Maija, Hellesøy, Monica, Dowling, Paul, Malyutina, Alina, Kopperud, Reidun, Bazou, Despina, Andersson, Emma, Parsons, Alun, Tang, Jing, Kallioniemi, Olli, Mustjoki, Satu, O'Gorman, Peter, Wennerberg, Krister, Porkka, Kimmo, Gjertsen, Bjørn T, Heckman, Caroline A

“…Innate drug sensitivity in healthy cells aids identification of lineage specific anti-cancer therapies and reveals off-target effects. To characterize the…”
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Shared genetic risk between eating disorder‐ and substance‐use‐related phenotypes: Evidence from genome‐wide association studies by Baker, Jessica H., Gordon, Scott, Mattheisen, Manuel, Ripke, Stephan, Yao, Shuyang, Adan, Roger A.H., Boraska Perica, Vesna, Cichon, Sven, Cone, Roger D., DeSocio, Janiece E., Docampo, Elisa, Escaramís, Geòrgia, Esko, Tõnu, Favaro, Angela, Fischer, Krista, Föcker, Manuel, Gonidakis, Fragiskos, Guillaume, Sébastien, Guo, Yiran, Hakonarson, Hakon, Hebebrand, Johannes, Helder, Sietske G., Herms, Stefan, Herzog, Wolfgang, Huckins, Laura M., Hudson, James I., Karhunen, Leila, Karwautz, Andreas, Kennedy, James L., Klump, Kelly L., Le Hellard, Stephanie, Lin, Bochao Danae, Meulenbelt, Ingrid, Mitchell, Karen, Monteleone, Alessio Maria, Nacmias, Benedetta, Ophoff, Roel A., Padyukov, Leonid, Palotie, Aarno, Pinto, Dalila, Ricca, Valdo, Ritschel, Franziska, Santonastaso, Paolo, Scherag, André, Seitz, Jochen, Slachtova, Lenka, Slof‐Op't Landt, Margarita C.T., Slopien, Agnieszka, Szatkiewicz, Jin P., Wagner, Gudrun, Walton, Esther, Widen, Elisabeth, Crawford, Steven, Johnson, Craig, Mitchell, James, Whiteman, David C., Birgegård, Andreas, Norring, Claes, Polimanti, Renato, Clarke, Toni‐Kim, Degenhardt, Franziska, Docherty, Anna R., Foo, Jerome C., Fox, Louis, Frank, Josef, Hack, Laura M., Lahti, Jari, Lahti‐Pulkkinen, Marius, Loukola, Anu, Palviainen, Teemu, Saccone, Nancy L., Salvatore, Jessica E., Strohmaier, Jana, Wang, Jen‐Chyong, Wills, Amanda G., Boardman, Jason D., Choi, Doo‐Sup, Culverhouse, Robert C., Dahmen, Norbert, Domingue, Benjamin W., Gäebel, Wolfgang, Ising, Marcus, Keyes, Margaret, Lucae, Susanne, Nurnberger, John I., Preuss, Ulrich, Bierut, Laura J., Brown, Sandra A., Costello, E. Jane, Eriksson, Johan G., Foroud, Tatiana M., Hesselbrock, Victor, Johnson, Eric O., Stallings, Michael C., Vrieze, Scott, Wade, Tracey D., Heath, Andrew C., Martin, Nicholas G., Breen, Gerome, Bulik, Cynthia M.

“…Eating disorders and substance use disorders frequently co‐occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and…”
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S120: ACUTE MYELOID LEUKEMIA REPRESENTS A FERROPTOSIS‐SENSITIVE CANCER ENTITY RAISING THE POSSIBILITY FOR NOVEL TARGETING STRATEGIES by Narr, A., Alborzinia, H., Donato, E., Vogel, F., Boch, T., Leppä, A.‐M., Waclawiczek, A., Renders, S., Schulze, A., Trumpp, A.

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PS973 BCL‐XL AS A PUTATIVE THERAPY TARGET IN ACUTE ERYTHROID LEUKEMIA by Kuusanmäki, H., Dufva, O., Leppä, A.‐M., Pölönen, P., Heinäniemi, M., Porkka, K., Kontro, M., Heckman, C., Mustjoki, S.

“…Background: Pharmacologic inhibition of pro‐survival Bcl‐2 family members (Bcl‐2, Mcl‐1, and BCL‐xL) has been extensively studied for acute myeloid leukemia…”
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Acute opioid effects on human brain as revealed by functional magnetic resonance imaging by Leppä, Mika, Korvenoja, Antti, Carlson, Synnöve, Timonen, Paula, Martinkauppi, Sami, Ahonen, Jouni, Rosenberg, Per H., Aronen, Hannu J., Kalso, Eija

“…Functional magnetic resonance imaging has been widely used to study brain activation induced either by specific sensory stimulation or motor or cognitive task…”
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