Search Results - "Lepescheux, Liên"
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Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis
Published in Journal of investigative dermatology (01-07-2018)“…IL-17C is a functionally distinct member of the IL-17 family that was believed to play a role in the pathogenesis of psoriasis. Here we confirmed that IL-17C…”
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Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases
Published in The Journal of immunology (1950) (01-10-2013)“…The JAKs receive continued interest as therapeutic targets for autoimmune, inflammatory, and oncological diseases. JAKs play critical roles in the development…”
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Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634
Published in Journal of medicinal chemistry (26-11-2014)“…Janus kinases (JAK1, JAK2, JAK3, and TYK2) are involved in the signaling of multiple cytokines important in cellular function. Blockade of the JAK-STAT pathway…”
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Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization
Published in BMC musculoskeletal disorders (03-09-2014)“…Muscle wasting is a hallmark of many chronic conditions but also of aging and results in a progressive functional decline leading ultimately to disability…”
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A multiparameter approach to monitor disease activity in collagen-induced arthritis
Published in Arthritis research & therapy (01-01-2010)“…Disease severity in collagen-induced arthritis (CIA) is commonly assessed by clinical scoring of paw swelling and histological examination of joints. Although…”
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Bone protection by estrens occurs through non-tissue-selective activation of the androgen receptor
Published in The Journal of clinical investigation (01-09-2006)“…The use of estrogens and androgens to prevent bone loss is limited by their unwanted side effects, especially in reproductive organs and breast. Selective…”
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Osteoblasts Are a New Target for Prolactin: Analysis of Bone Formation in Prolactin Receptor Knockout MiceThis work was supported in part by grants from Hoechst Marion Roussel, Inc
Published in Endocrinology (Philadelphia) (01-01-1999)“…Bone development is a multistep process that includes patterning of skeletal elements, commitment of hematopoietic and/or mesenchymental cells to chondrogenic…”
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Spatial organization of collagen in annelid cuticle: order and defects
Published in Biology of the cell (1988)“…The epidermis of Paralvinella grasslei (Polychaete, Annelida) is covered by an extracellular matrix, the cuticle, mainly composed as in other annelids of…”
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Osteoblasts Are a New Target for Prolactin: Analysis of Bone Formation in Prolactin Receptor Knockout Mice1
Published in Endocrinology (Philadelphia) (01-01-1999)“…Bone development is a multistep process that includes patterning of skeletal elements, commitment of hematopoietic and/or mesenchymental cells to chondrogenic…”
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Osteoblasts Are a New Target for Prolactin: Analysis of Bone Formation in Prolactin Receptor Knockout Mice
Published in Obstetrical & gynecological survey (01-06-1999)Get full text
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A discrete helicoid of collagenous fibrils: the cuticle of deep-sea hydrothermal vent worms (Riftia pachyptila)
Published in Matrix (Stuttgart) (01-06-1991)“…The fibrillar organization of the collagenous cuticle of the hydrothermal vent worm Riftia pachyptila is described. Fibrils in the posterior part of the…”
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