Search Results - "Lepage, Gilbert"
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Regulation of Activity of Transient Receptor Potential Melastatin 8 (TRPM8) Channel by Its Short Isoforms
Published in The Journal of biological chemistry (27-01-2012)“…One important mechanism of the regulation of membrane ion channels involves their nonfunctional isoforms generated by alternative splicing. However, knowledge…”
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Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells
Published in Oncotarget (17-05-2016)“…Since its cloning a decade ago, TRPM8 channel has emerged as a promising prognostic marker and a putative therapeutic target in prostate cancer (PCa). However,…”
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Two Types of Store-operated Ca2+ Channels with Different Activation Modes and Molecular Origin in LNCaP Human Prostate Cancer Epithelial Cells
Published in The Journal of biological chemistry (16-07-2004)“…The one or more coupling mechanisms of store-operated channels (SOCs) to endoplasmic reticulum (ER) Ca 2+ store depletion as well as the molecular identity of…”
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Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma
Published in Biochimica et biophysica acta (01-10-2014)“…The store-operated calcium channels (SOCs) represent one of the major calcium-entry pathways in non-excitable cells. SOCs and in particular their major…”
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Remodeling of Channel-Forming ORAI Proteins Determines an Oncogenic Switch in Prostate Cancer
Published in Cancer cell (14-07-2014)“…ORAI family channels have emerged as important players in malignant transformation, yet the way in which they reprogram cancer cells remains elusive. Here we…”
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Modulation of ER stress and apoptosis by endoplasmic reticulum calcium leak via translocon during unfolded protein response: involvement of GRP78
Published in The FASEB journal (01-04-2013)“…The endoplasmic reticulum (ER) is involved in many cellular functions, including protein folding and Ca2+ homeostasis. The ability of cells to respond to the…”
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Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells
Published in Oncotarget (09-04-2016)Get full text
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8
Regulation of Activity of Transient Receptor Potential Melastatin 8 (TRPM8) Channel by Its Short Isoforms
Published in The Journal of biological chemistry (01-01-2012)Get full text
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9
Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells: Orai1 in apoptosis resistance of prostate cancer
Published in Cell death & disease (01-09-2010)“…The molecular nature of calcium (Ca(2+))-dependent mechanisms and the ion channels having a major role in the apoptosis of cancer cells remain a subject of…”
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Alterations in the regulatory volume decrease (RVD) and swelling-activated Cl−current associated with neuroendocrine differentiation of prostate cancer epithelial cells
Published in Endocrine-related cancer (01-06-2005)“…Neuroendocrine (NE) differentiation of prostate epithelial/basal cells is a hallmark of advanced, androgen-independent prostate cancer, for which there is no…”
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Receptor-coupled, DAG-gated Ca2+-permeable cationic channels in LNCaP human prostate cancer epithelial cells
Published in The Journal of physiology (01-05-2003)“…Although the prostate gland is a rich source of α1-adreno- (α1-AR) and m1-cholino receptors (m1-AChR), the membrane processes associated with their…”
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Role of endoplasmic reticulum calcium content in prostate cancer cell growth regulation by IGF and TNFalpha
Published in Journal of cellular physiology (01-11-2004)“…Variations in calcium concentration within the endoplasmic reticulum ([Ca2+]ER) may play a role in cell growth. This study evaluates the regulation of calcium…”
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13
Two Types of Store-operated Ca super(2)+ Channels with Different Activation Modes and Molecular Origin in LNCaP Human Prostate Cancer Epithelial Cells
Published in The Journal of biological chemistry (16-07-2004)“…The one or more coupling mechanisms of store-operated channels (SOCs) to endoplasmic reticulum (ER) Ca super(2+) store depletion as well as the molecular…”
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Journal Article -
14
Two types of store-operated Ca2+ channels with different activation modes and molecular origin in LNCaP human prostate cancer epithelial cells
Published in The Journal of biological chemistry (16-07-2004)“…The one or more coupling mechanisms of store-operated channels (SOCs) to endoplasmic reticulum (ER) Ca2+ store depletion as well as the molecular identity of…”
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Journal Article -
15
Molecular cloning, expression analysis and iron metal cofactor characterisation of a superoxide dismutase from Toxoplasma gondii
Published in Molecular and biochemical parasitology (25-02-2000)“…A genomic region of 12kb encompassing the gene encoding the superoxide dismutase (SOD) of Toxoplasma gondii has been cloned. The gene contains four exons of…”
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1H-NMR spectroscopy of manno-oligosaccharides of the beta-1,2-linked series released from the phosphopeptidomannan of Candida albicans VW-32 (serotype A)
Published in Biochemical and biophysical research communications (31-12-1991)“…Manno-oligosaccharides (DP 2 to greater than 15) were released by mild acid hydrolysis from the phosphopeptidomannan of a Candida albicans strain of A serotype…”
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