Search Results - "Lepage, Come"

Digestive Neuroendocrine Neoplasms (NEN): French Intergroup clinical practice guidelines for diagnosis, treatment and follow-up (SNFGE, GTE, RENATEN, TENPATH, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, SFR) by de Mestier, Louis, Lepage, Come, Baudin, Eric, Coriat, Romain, Courbon, Frédéric, Couvelard, Anne, Do Cao, Christine, Frampas, Eric, Gaujoux, Sébastien, Gincul, Rodica, Goudet, Pierre, Lombard-Bohas, Catherine, Poncet, Gilles, Smith, Denis, Ruszniewski, Philippe, Lecomte, Thierry, Bouché, Olivier, Walter, Thomas, Cadiot, Guillaume

“…This document is a summary of the French Intergroup guidelines regarding the management of digestive neuroendocrine neoplasms (NEN) published in February 2020…”
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Oxaliplatin, fluorouracil, and leucovorin with or without cetuximab in patients with resected stage III colon cancer (PETACC-8): an open-label, randomised phase 3 trial by Taieb, Julien, Prof, Tabernero, Josep, Prof, Mini, Enrico, Prof, Subtil, Fabien, PhD, Folprecht, Gunnar, MD, Van Laethem, Jean-Luc, Prof, Thaler, Josef, Prof, Bridgewater, John, MD, Petersen, Lone Nørgård, Prof, Blons, Hélène, PhD, Collette, Laurence, PhD, Van Cutsem, Eric, Prof, Rougier, Philippe, Prof, Salazar, Ramon, Prof, Bedenne, Laurent, Prof, Emile, Jean-François, Prof, Laurent-Puig, Pierre, Prof, Lepage, Come, Prof

“…Summary Background Since the 1990s, fluorouracil-based adjuvant chemotherapy has significantly reduced the risk of tumour recurrence in patients with stage III…”
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The transfer of multigene panel testing for hereditary breast and ovarian cancer to healthcare: What are the implications for the management of patients and families? by Eliade, Marie, Skrzypski, Jeremy, Baurand, Amandine, Jacquot, Caroline, Bertolone, Geoffrey, Loustalot, Catherine, Coutant, Charles, Guy, France, Fumoleau, Pierre, Duffourd, Yannis, Arnould, Laurent, Delignette, Alexandra, Padéano, Marie-Martine, Lepage, Côme, Raichon-Patru, Géraldine, Boudrant, Axelle, Bône-Lépinoy, Marie-Christine, Villing, Anne-Laure, Charpin, Aurélie, Peignaux, Karine, Chevrier, Sandy, Vegran, Frédérique, Ghiringhelli, François, Boidot, Romain, Sevenet, Nicolas, Lizard, Sarab, Faivre, Laurence

“…Until recently, the molecular diagnosis of hereditary breast and ovarian cancer (HBOC) was mostly based on BRCA1/2 testing. Next generation sequencing and the…”
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FFCD-1004 Clinical Trial: Impact of Cytidine Deaminase Activity on Clinical Outcome in Gemcitabine-Monotherapy Treated Patients by Serdjebi, Cindy, Gagnière, Johan, Desramé, Jérôme, Fein, Francine, Guimbaud, Rosine, François, Eric, André, Thierry, Seitz, Jean-François, Montérymard, Carole, Arsene, Dominique, Volet, Julien, Abakar-Mahamat, Abakar, Lecomte, Thierry, Guerin-Meyer, Véronique, Legoux, Jean-Louis, Deplanque, Gaël, Guillet, Pierre, Ciccolini, Joseph, Lepage, Côme, Dahan, Laetitia

“…Because cytidine deaminase (CDA) is the key enzyme in gemcitabine metabolism, numerous studies have attempted to investigate impact of CDA status (i.e…”
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Trends in gastric cancer incidence: a period and birth cohort analysis in a well-defined French population by Nicolas, Chapelle, Sylvain, Manfredi, Come, Lepage, Jean, Faivre, Anne-Marie, Bouvier, Valérie, Jooste

“…Background The incidence of gastric cancer has declined over the past decades. Little is known about trends by site and histological subtype. The aim of this…”
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FOLFIRI Plus Durvalumab With or Without Tremelimumab in Second-Line Treatment of Advanced Gastric or Gastroesophageal Junction Adenocarcinoma: The PRODIGE 59-FFCD 1707-DURIGAST Randomized Clinical Trial by Tougeron, David, Dahan, Laetitia, Evesque, Ludovic, Le Malicot, Karine, El Hajbi, Farid, Aparicio, Thomas, Bouché, Olivier, Bonichon Lamichhane, Nathalie, Chibaudel, Benoist, Angelergues, Antoine, Bodere, Anaïs, Phelip, Jean-Marc, Mabro, May, Kaluzinski, Laure, Petorin, Caroline, Breysacher, Gilles, Rinaldi, Yves, Zaanan, Aziz, Smith, Denis, Gouttebel, Marie-Claude, Perret, Clément, Etchepare, Nicolas, Emile, Jean-François, Sanfourche, Ivan, Di Fiore, Frédéric, Lepage, Côme, Artru, Pascal, Louvet, Christophe

“…Efficacy of second-line chemotherapy in advanced gastric or gastrooesphageal junction (GEJ) adenocarcinoma remains limited. To determine the efficacy of 1 or 2…”
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Implementation and use of whole exome sequencing for metastatic solid cancer by Réda, Manon, Richard, Corentin, Bertaut, Aurelie, Niogret, Julie, Collot, Thomas, Fumet, Jean David, Blanc, Julie, Truntzer, Caroline, Desmoulins, Isabelle, Ladoire, Sylvain, Hennequin, Audrey, Favier, Laure, Bengrine, Leila, Vincent, Julie, Hervieu, Alice, Dusserre, Jean-Florian Guion, Lepage, Come, Foucher, Pascal, Borg, Christophe, Albuisson, Juliette, Arnould, Laurent, Nambot, Sophie, Faivre, Laurence, Boidot, Romain, Ghiringhelli, Francois

“…Genomically-guided clinical trials are performed across different tumor types sharing genetic mutations, but trial organization remains complex. Here we…”
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Daily practices in chemotherapy for advanced gastric or gastroesophageal junction adenocarcinoma: METESTOMAC French prospective cohort by Manfredi, Sylvain, Dior, Marie, Bouche, Olivier, Barbier, Emilie, Hautefeuille, Vincent, Guillet, Marielle, Turpin, Justine, Bourgeois, Vincent, Helene, Dall Osto, Desgrippes, Romain, Audemar, Franck, Molin, Yann, Locher, Christophe, Chatellier, Thierry, Lecomte, Thierry, Baize, Nathalie, Lecaille, Cedric, Spaeth, Dominique, Goujon, Gael, Lepage, Come, Tougeron, David

“…Background Around 50% of gastric cancers are diagnosed at an advanced stage. Several chemotherapy regimens are now internationally validated. Few data are…”
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Safety of FOLFIRI + Durvalumab +/- Tremelimumab in Second Line of Patients with Advanced Gastric Cancer: A Safety Run-In from the Randomized Phase II Study DURIGAST PRODIGE 59 by Evrard, Camille, Aparicio, Thomas, Soularue, Emilie, Le Malicot, Karine, Desramé, Jérôme, Botsen, Damien, El Hajbi, Farid, Gonzalez, Daniel, Lepage, Come, Bouché, Olivier, Tougeron, David, On Behalf Of The Durigast-Prodige Investigators/Collaborators

“…Efficacy of immune checkpoint inhibitors (ICI) as monotherapy in 2nd line treatment for gastric or gastro-oesophageal junction (GEJ) adenocarcinoma is low,…”
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Colorectal cancer survival in the USA and Europe: a CONCORD high-resolution study by Allemani, Claudia, Rachet, Bernard, Weir, Hannah K, Richardson, Lisa C, Lepage, Côme, Faivre, Jean, Gatta, Gemma, Capocaccia, Riccardo, Sant, Milena, Baili, Paolo, Lombardo, Claudio, Aareleid, Tiiu, Ardanaz, Eva, Bielska-Lasota, Magdalena, Bolick, Susan, Cress, Rosemary, Elferink, Marloes, Fulton, John P, Galceran, Jaume, Góźdź, Stanisław, Hakulinen, Timo, Primic-Žakelj, Maja, Rachtan, Jadwiga, Diba, Chakameh Safaei, Sánchez, Maria-José, Schymura, Maria J, Shen, Tiefu, Tagliabue, Giovanna, Tumino, Rosario, Vercelli, Marina, Wolf, Holly J, Wu, Xiao-Cheng, Coleman, Michel P

“…Objectives To assess the extent to which stage at diagnosis and adherence to treatment guidelines may explain the persistent differences in colorectal cancer…”
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337 Pembrolizumab in combination with xelox bevacizumab in patients with microsatellite stable (MSS) metastatic colorectal cancer and a high immune infiltrate: a proof of concept study. FFCD 1703 POCHI by Tougeron, David, Emile, Jean Francois, Kim, Stephano, Monterymard, Carole, Gilabert, Marine, Jérémie, BEZ, Lievre, Astrid, Dahan, Laetitia, Laurent-puig, Pierre, Mineur, Laurent, Coriat, ROmain, Legoux, Jean Louis, Hautefeuille, Vincent, Phelip, Jean marc, Lecomte, Thierry, Sokol, Harry, Capron, Claude, Gallois, Claire, Randrian, Violaine, Lepage, Come, Taieb, Julien

“…BackgroundImmune checkpoint inhibitors (ICI) are very effective in deficient DNA mismatch-repair system (dMMR)/microsatellite instable (MSI) metastatic…”
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PIK3CA mutations predict recurrence in localized microsatellite stable colon cancer by Manceau, Gilles, Marisa, Laetitia, Boige, Valérie, Duval, Alex, Gaub, Marie‐Pierre, Milano, Gérard, Selves, Janick, Olschwang, Sylviane, Jooste, Valérie, Legrain, Michè, Lecorre, Delphine, Guenot, Dominique, Etienne‐Grimaldi, Marie‐Christine, Kirzin, Sylvain, Martin, Laurent, Lepage, Come, Bouvier, Anne‐Marie, Laurent‐Puig, Pierre

“…PIK3CA, which encodes the p110α catalytic subunit of PI3Kα, is one of the most frequently altered oncogenes in colon cancer (CC), but its prognostic value is…”
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Intratumor CMS Heterogeneity Impacts Patient Prognosis in Localized Colon Cancer by Marisa, Laetitia, Blum, Yuna, Taieb, Julien, Ayadi, Mira, Pilati, Camilla, Le Malicot, Karine, Lepage, Côme, Salazar, Ramon, Aust, Daniela, Duval, Alex, Blons, Hélène, Taly, Valérie, Gentien, David, Rapinat, Audrey, Selves, Janick, Mouillet-Richard, Sophie, Boige, Valérie, Emile, Jean-François, de Reyniès, Aurélien, Laurent-Puig, Pierre

“…The consensus molecular subtypes (CMS) represent a significant advance in the understanding of intertumor heterogeneity in colon cancer. Intratumor…”
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A colonoscopy quality improvement intervention in an endoscopy unit by Palmier, Rémi, Degand, Thibault, Aho, Serge, Lepage, Côme, Facy, Olivier, Michiels, Christophe, Manfredi, Sylvain

“…Many studies identified colonoscopy quality indicators in order to improve performance and safety. We conducted a colonoscopy improvement study. Our study was…”
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Epidemiology and management of liver metastases from colorectal cancer by MANFREDI, Sylvain, LEPAGE, Come, HATEM, Cyril, COATMEUR, Olivier, FAIVRE, Jean, BOUVIER, Anne-Marie

“…Little is known about the epidemiology and the management of liver metastases from colorectal cancer at a population level. The aim of this population-based…”
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Continuing Rapid Increase in Esophageal Adenocarcinoma in England and Wales by LEPAGE, Come, RACHET, Bernard, JOOSTE, Valérie, FAIVRE, Jean, COLEMAN, Michel P

“…Substantial changes have occurred in the epidemiology of esophageal adenocarcinoma. We examined trends in incidence in a large national population. All…”
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Well-differentiated grade 3 digestive neuroendocrine tumors: Myth or reality? The PRONET study group by Scoazec, Jean-Yves, Couvelard, Anne, Monges, Genevieve, Leteurtre, Emmanuelle, Belleannee, Genevieve, Guyetant, Serge, Duvillard, Pierre, Danjoux, Marie, Parot, Xavier, Lepage, Come

“…Abstract only 4129 Background: In contrast to the 2000 World Health Organization (WHO) classification of digestive neuroendocrine tumors (NET) in which…”
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Efficacy of donepezil for the treatment of oxaliplatin-induced peripheral neuropathy: DONEPEZOX, a protocol of a proof of concept, randomised, triple-blinded and multicentre trial by Kerckhove, Nicolas, Tougeron, David, Lepage, Côme, Pezet, Denis, Le Malicot, Karine, Pelkowski, Manon, Pereira, Bruno, Balayssac, David

“…The use of oxaliplatin in digestive tract cancers could induce severe peripheral neuropathy (OIPN) decreasing the quality of life of patients and survivors…”
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Targeted therapies and immunotherapy: Positioning in the field of innovation and challenges for the therapeutic decision-making process by El Chami, Carole, Meunier-Beillard, Nicolas, Binquet, Christine, Lepage, Côme, Lejeune, Catherine

“…The better understanding of the molecular, cellular, and immunological mechanisms of cancer has led to the development of targeted therapies, then…”
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Study of Small Intestinal Bacterial Overgrowth in a Cohort of Patients with Abdominal Symptoms Who Underwent Bariatric Surgery by Mouillot, Thomas, Rhyman, Nybel, Gauthier, Cyril, Paris, Justine, Lang, Anne-Sophie, Lepers-Tassy, Sarah, Manfredi, Sylvain, Lepage, Côme, Leloup, Corinne, Jacquin-Piques, Agnès, Brindisi, Marie-Claude, Brondel, Laurent

“…Introduction Small intestinal bacterial overgrowth (SIBO) is a common complication of bariatric surgery. Digestive decontamination treatments with oral…”
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