Search Results - "Lepšík, M."

Efficiency of a second-generation HIV-1 protease inhibitor studied by molecular dynamics and absolute binding free energy calculations by Lepšík, M., Kříž, Z., Havlas, Z.

“…A subnanomolar inhibitor of human immunodeficiency virus type 1 (HIV‐1) protease, designated QF34, potently inhibits the wild‐type and drug‐resistant enzyme…”
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A Phenylnorstatine Inhibitor Binding to HIV-1 Protease:  Geometry, Protonation, and Subsite−Pocket Interactions Analyzed at Atomic Resolution by Brynda, Jiri, Rezacova, Pavlina, Fabry, Milan, Horejsi, Magdalena, Stouracova, Renata, Sedlacek, Juraj, Soucek, Milan, Hradilek, Martin, Lepsik, Martin, Konvalinka, Jan

“…The X-ray structure of a complex of HIV-1 protease (PR) with a phenylnorstatine inhibitor Z-Pns-Phe-Glu-Glu-NH2 has been determined at 1.03 Å, the highest…”
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Unusual Binding Mode of an HIV-1 Protease Inhibitor Explains its Potency against Multi-drug-resistant Virus Strains by Weber, Jan, Mesters, Jeroen R, Lepšı́k, Martin, Prejdová, Jana, Švec, Martin, Šponarová, Jana, Mlčochová, Petra, Skalická, Kristina, Střı́šovský, Kvido, Uhlı́ková, Táňa, Souček, Milan, Machala, Ladislav, Staňková, Marie, Vondrášek, Jiřı́, Klimkait, Thomas, Kraeusslich, Hans-Georg, Hilgenfeld, Rolf, Konvalinka, Jan

“…Protease inhibitors (PIs) are an important class of drugs for the treatment of HIV infection. However, in the course of treatment, resistant viral variants…”
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