Search Results - "Leonova, Elena I."

CRISPR/Cas9 Technology in Translational Biomedicine by Leonova, Elena I, Gainetdinov, Raul R

“…The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) - RNA-guided Cas9 endonuclease system has provided a fast and efficient method for…”
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Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors by Glyakina, Anna V, Pavlov, Constantine D, Sopova, Julia V, Gainetdinov, Raul R, Leonova, Elena I, Galzitskaya, Oxana V

“…The identification and characterization of ligand-receptor binding sites are important for drug development. Trace amine-associated receptors (TAARs, members…”
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Does Background Matter? A Comparative Characterization of Mouse Models of Autosomal Retinitis Pigmentosa rd1 and Pde6b-KO by Chirinskaite, Angelina V, Rotov, Alexander Yu, Ermolaeva, Mariia E, Tkachenko, Lyubov A, Vaganova, Anastasia N, Danilov, Lavrentii G, Fedoseeva, Ksenia N, Kostin, Nicolay A, Sopova, Julia V, Firsov, Michael L, Leonova, Elena I

“…Many retinal degenerative diseases result in vision impairment or permanent blindness due to photoreceptor loss or dysfunction. It has been observed that Pde6b…”
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Translational potential of base-editing tools for gene therapy of monogenic diseases by Reshetnikov, Vasiliy V, Chirinskaite, Angelina V, Sopova, Julia V, Ivanov, Roman A, Leonova, Elena I

“…Millions of people worldwide have rare genetic diseases that are caused by various mutations in DNA sequence. Classic treatments of rare genetic diseases are…”
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New PAM Improves the Single-Base Specificity of crRNA-Guided LbCas12a Nuclease by Misiurina, Mariia A, Chirinskaite, Angelina V, Fotina, Aleksandra S, Zelinsky, Andrey A, Sopova, Julia V, Leonova, Elena I

“…The RNA-guided Cas12a nuclease forms a complex with a CRISPR RNA (crRNA) to cleave the double-stranded DNA target. Among others, Cas12a protein from (LbCas12a)…”
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Cas-Based Systems for RNA Editing in Gene Therapy of Monogenic Diseases: In Vitro and in Vivo Application and Translational Potential by Reshetnikov, Vasiliy V, Chirinskaite, Angelina V, Sopova, Julia V, Ivanov, Roman A, Leonova, Elena I

“…Rare genetic diseases reduce quality of life and can significantly shorten the lifespan. There are few effective treatment options for these diseases, and…”
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Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations by Tsytsarev, Vassiliy, Sopova, Julia V., Leonova, Elena I., Inyushin, Mikhail, Markina, Alisa A., Chirinskaite, Angelina V., Volnova, Anna B.

“…Neurophotonic technology is a rapidly growing group of techniques that are based on the interactions of light with natural or genetically modified cells of the…”
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Features of DNA Repair in the Early Stages of Mammalian Embryonic Development by Khokhlova, Evgenia V., Fesenko, Zoia S., Sopova, Julia V., Leonova, Elena I.

“…Cell repair machinery is responsible for protecting the genome from endogenous and exogenous effects that induce DNA damage. Mutations that occur in somatic…”
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CRISPR/Cas-edited pigs for personalized medicine: more than preclinical test-system by Leonova, Elena I., Reshetnikov, Vasily V., Sopova, Julia V.

“…Novel CRISPR-Cas-based genome editing tools made it feasible to introduce a variety of precise genomic modifications in the pig genome, including introducing…”
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Atherosclerosis is a side effect of cellular senescence by Leonova, Elena I., Chirinskaite, Angelina V., Sopova, Julia V.

“…Atherosclerosis is a systemic autoimmune disease of the arterial wall characterized by chronic inflammation, high blood pressure, oxidative stress, and…”
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Cell communication using intrinsically disordered proteins: what can syndecans say? by Leonova, Elena I., Galzitskaya, Oxana V.

“…Because intrinsically disordered proteins are incapable of forming unique tertiary structures in isolation, their interaction with partner structures enables…”
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Role of Syndecans in Lipid Metabolism and Human Diseases by Leonova, Elena I, Galzitskaya, Oxana V

“…Syndecans are transmembrane heparan sulfate proteoglycans involved in the regulation of cell growth, differentiation, adhesion, neuronal development, and lipid…”
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Hepatic and Aortic Arch Expression and Serum Levels of Syndecan-1 in ApoE -/- Mice by Leonova, Elena I, Sadovnikova, Elena S, Shaykhutdinova, Elvira R, Galzitskaya, Oxana V, Murashev, Arkady N, Solonin, Alexandr S

“…Heparan sulfate proteoglycan (HSPG) syndecan-1 (Sdc1) acts as a receptor for triglyceride-rich lipoproteins (TRLs), growth factors, chemokines and enzymes. Due…”
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