Search Results - "Leoni, A"

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy by Ashton, Thomas M, McKenna, W Gillies, Kunz-Schughart, Leoni A, Higgins, Geoff S

“…Cancer cells have upregulated glycolysis compared with normal cells, which has led many to the assumption that oxidative phosphorylation (OXPHOS) is…”
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Spheroid-based drug screen: considerations and practical approach by Kunz-Schughart, Leoni A, Friedrich, Juergen, Seidel, Claudia, Ebner, Reinhard

“…Although used in academic research for several decades, 3D culture models have long been regarded expensive, cumbersome and unnecessary in drug development…”
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Multicellular tumor spheroids: An underestimated tool is catching up again by Hirschhaeuser, Franziska, Menne, Heike, Dittfeld, Claudia, West, Jonathan, Mueller-Klieser, Wolfgang, Kunz-Schughart, Leoni A.

“…The present article highlights the rationale, potential and flexibility of tumor spheroid mono- and cocultures for implementation into state of the art…”
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Phosphoinositides and the Fate of Legionella in Phagocytes by Swart, A Leoni, Hilbi, Hubert

“…is the causative agent of a severe pneumonia called Legionnaires' disease. The environmental bacterium replicates in free-living amoebae as well as in lung…”
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Is there an influence of perceptual or cognitive impairment on complex sentence processing in hearing aid users? by Wagner, Luise, Werle, Anna-Leoni A, Hoffmann, Antonia, Rahne, Torsten, Fengler, Anja

“…Background Hearing-impaired listeners often have difficulty understanding complex sentences. It is not clear if perceptual or cognitive deficits have more…”
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CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges by Grosse-Gehling, Philipp, Fargeas, Christine A, Dittfeld, Claudia, Garbe, Yvette, Alison, Malcolm R, Corbeil, Denis, Kunz-Schughart, Leoni A

“…The cancer stem cell (CSC) hypothesis, despite the limitations of the currently available models and assays, has ushered in a new era of excitement in cancer…”
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Encapsulation of a Cr III Single-Ion Magnet within an Fe II Spin-Crossover Supramolecular Host by Darawsheh, Mohanad, Barrios, Leoní A, Roubeau, Olivier, Teat, Simon J, Aromí, Guillem

“…Single functional molecules are regarded as future components of nanoscale spintronic devices. Supramolecular coordination chemistry provides unlimited…”
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A heterometallic [LnLn′Ln] lanthanide complex as a qubit with embedded quantum error correction by Macaluso, Emilio, Rubín, Marcos, Aguilà, David, Chiesa, Alessandro, Barrios, Leoní A, Martínez, Jesús I, Alonso, Pablo J, Roubeau, Olivier, Luis, Fernando, Aromí, Guillem, Carretta, Stefano

“…We show that a [Er-Ce-Er] molecular trinuclear coordination compound is a promising platform to implement the three-qubit quantum error correction code…”
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Acanthamoeba and Dictyostelium as Cellular Models for Legionella Infection by Swart, A Leoni, Harrison, Christopher F, Eichinger, Ludwig, Steinert, Michael, Hilbi, Hubert

“…Environmental bacteria of the genus naturally parasitize free-living amoebae. Upon inhalation of bacteria-laden aerosols, the opportunistic pathogens grow…”
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Dictyostelium lacking the single atlastin homolog Sey1 shows aberrant ER architecture, proteolytic processes and expansion of the Legionella‐containing vacuole by Hüsler, Dario, Steiner, Bernhard, Welin, Amanda, Striednig, Bianca, Swart, A. Leoni, Molle, Virginie, Hilbi, Hubert, Letourneur, François

“…Dictyostelium discoideum Sey1 is the single ortholog of mammalian atlastin 1–3 (ATL1‐3), which are large homodimeric GTPases mediating homotypic fusion of…”
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The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia by Ashton, Thomas M., Fokas, Emmanouil, Kunz-Schughart, Leoni A., Folkes, Lisa K., Anbalagan, Selvakumar, Huether, Melanie, Kelly, Catherine J., Pirovano, Giacomo, Buffa, Francesca M., Hammond, Ester M., Stratford, Michael, Muschel, Ruth J., Higgins, Geoff S., McKenna, William Gillies

“…Tumour hypoxia renders cancer cells resistant to cancer therapy, resulting in markedly worse clinical outcomes. To find clinical candidate compounds that…”
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Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release by GOETZE, Kristina, WALENTA, Stefan, KSLAZKIEWICZ, Magdalena, KUNZ-SCHUGHART, Leoni A, MUELLER-KLIESER, Wolfgang

“…In solid malignant tumors, lactate has been identified as a prognostic parameter for metastasis and overall survival of patients. To investigate the effects of…”
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Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5 by Bärlocher, Kevin, Hutter, Cedric A. J., Swart, A. Leoni, Steiner, Bernhard, Welin, Amanda, Hohl, Michael, Letourneur, François, Seeger, Markus A., Hilbi, Hubert

“…Legionella pneumophila can cause Legionnaires’ disease and replicates intracellularly in a distinct Legionella -containing vacuole (LCV). LCV formation is a…”
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Impact of distant peptide substrate residues on enzymatic activity of SlyD by Pazicky, Samuel, Werle, Anna-Leoni A., Lei, Jian, Löw, Christian, Weininger, Ulrich

“…Peptidyl-prolyl isomerases (PPIases) catalyze intrinsically slow and often rate-limiting isomerization of prolyl-peptide bonds in unfolded or partially folded…”
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Salmonella enterica Remodels the Host Cell Endosomal System for Efficient Intravacuolar Nutrition by Liss, Viktoria, Swart, A. Leoni, Kehl, Alexander, Hermanns, Natascha, Zhang, Yuying, Chikkaballi, Deepak, Böhles, Nathalie, Deiwick, Jörg, Hensel, Michael

“…Salmonella enterica is a facultative intracellular pathogen that survives and proliferates in the Salmonella-containing vacuole (SCV), yet how these vacuolar…”
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Energy exchange between Nd3+ and Er3+ centers within molecular complexes by Maniaki, Diamantoula, Sickinger, Annika, Barrios, Leoní A, Aguilà, David, Roubeau, Olivier, Guyot, Yannick, Riobé, François, Maury, Olivier, Laura Abad Galán, Aromí, Guillem

“…Developing controlled and reproducible molecular assemblies incorporating lanthanide centers is a crucial step for driving forward up- and down-conversion…”
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GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy by Mukha, Anna, Kahya, Uğur, Linge, Annett, Chen, Oleg, Löck, Steffen, Lukiyanchuk, Vasyl, Richter, Susan, Alves, Tiago C, Peitzsch, Mirko, Telychko, Vladyslav, Skvortsov, Sergej, Negro, Giulia, Aschenbrenner, Bertram, Skvortsova, Ira-Ida, Mirtschink, Peter, Lohaus, Fabian, Hölscher, Tobias, Neubauer, Hans, Rivandi, Mahdi, Labitzky, Vera, Lange, Tobias, Franken, André, Behrens, Bianca, Stoecklein, Nikolas H, Toma, Marieta, Sommer, Ulrich, Zschaeck, Sebastian, Rehm, Maximilian, Eisenhofer, Graeme, Schwager, Christian, Abdollahi, Amir, Groeben, Christer, Kunz-Schughart, Leoni A, Baretton, Gustavo B, Baumann, Michael, Krause, Mechthild, Peitzsch, Claudia, Dubrovska, Anna

“…Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa). The curative potential of radiotherapy is mediated by…”
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Guest-, Light- and Thermally-Modulated Spin Crossover in [FeII2] Supramolecular Helicates by Darawsheh, Mohanad, Barrios, Leoni A., Roubeau, Olivier, Teat, Simon J., Aromí, Guillem

“…A new bis(pyrazolylpyridine) ligand (H2L) has been prepared to form functional [Fe2(H2L)3]4+ metallohelicates. Changes to the synthesis yield six derivatives,…”
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Nanoparticles for radiooncology: Mission, vision, challenges by Kunz-Schughart, Leoni A, Dubrovska, Anna, Peitzsch, Claudia, Ewe, Alexander, Aigner, Achim, Schellenburg, Samuel, Muders, Michael H, Hampel, Silke, Cirillo, Giuseppe, Iemma, Francesca, Tietze, Rainer, Alexiou, Christoph, Stephan, Holger, Zarschler, Kristof, Vittorio, Orazio, Kavallaris, Maria, Parak, Wolfgang J, Mädler, Lutz, Pokhrel, Suman

“…Abstract Cancer is one of the leading non-communicable diseases with highest mortality rates worldwide. About half of all cancer patients receive radiation…”
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Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes by Dietl, Katrin, Renner, Kathrin, Dettmer, Katja, Timischl, Birgit, Eberhart, Karin, Dorn, Christoph, Hellerbrand, Claus, Kastenberger, Michael, Kunz-Schughart, Leoni A, Oefner, Peter J, Andreesen, Reinhard, Gottfried, Eva, Kreutz, Marina P

“…High concentrations of lactic acid (LA) are found under various pathophysiological conditions and are accompanied by an acidification of the environment. To…”
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