Search Results - "Leong, W."

Advanced materials and processing for drug delivery: The past and the future by Zhang, Ying, Chan, Hon Fai, Leong, Kam W.

“…Design and synthesis of efficient drug delivery systems are of vital importance for medicine and healthcare. Materials innovation and nanotechnology have…”
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CRISPR/Cas9-Based Genome Editing for Disease Modeling and Therapy: Challenges and Opportunities for Nonviral Delivery by Wang, Hong-Xia, Li, Mingqiang, Lee, Ciaran M, Chakraborty, Syandan, Kim, Hae-Won, Bao, Gang, Leong, Kam W

“…Genome editing offers promising solutions to genetic disorders by editing DNA sequences or modulating gene expression. The clustered regularly interspaced…”
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Design of therapeutic biomaterials to control inflammation by Tu, Zhaoxu, Zhong, Yiling, Hu, Hanze, Shao, Dan, Haag, Rainer, Schirner, Michael, Lee, Jaewoo, Sullenger, Bruce, Leong, Kam W.

“…Inflammation plays an important role in the response to danger signals arising from damage to our body and in restoring homeostasis. Dysregulated inflammatory…”
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Lipid Nanoparticles as Delivery Vehicles for Inhaled Therapeutics by Leong, Ellenmae W X, Ge, Ruowen

“…Lipid nanoparticles (LNPs) have emerged as a powerful non-viral carrier for drug delivery. With the prevalence of respiratory diseases, particularly…”
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Biomimetic Diselenide‐Bridged Mesoporous Organosilica Nanoparticles as an X‐ray‐Responsive Biodegradable Carrier for Chemo‐Immunotherapy by Shao, Dan, Zhang, Fan, Chen, Fangman, Zheng, Xiao, Hu, Hanze, Yang, Chao, Tu, Zhaoxu, Wang, Zheng, Chang, Zhimin, Lu, Junna, Li, Tianyu, Zhang, Yuan, Chen, Li, Leong, Kam W., Dong, Wen‐fei

“…Chemotherapy causes off‐target toxicity and is often ineffective against solid tumors. Targeted and on‐demand release of chemotherapeutics remains a challenge…”
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Bioinspired Diselenide‐Bridged Mesoporous Silica Nanoparticles for Dual‐Responsive Protein Delivery by Shao, Dan, Li, Mingqiang, Wang, Zheng, Zheng, Xiao, Lao, Yeh‐Hsing, Chang, Zhimin, Zhang, Fan, Lu, Mengmeng, Yue, Juan, Hu, Hanze, Yan, Huize, Chen, Li, Dong, Wen‐fei, Leong, Kam W.

“…Controlled delivery of protein therapeutics remains a challenge. Here, the inclusion of diselenide‐bond‐containing organosilica moieties into the framework of…”
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Cell-laden microfluidic microgels for tissue regeneration by Jiang, Weiqian, Li, Mingqiang, Chen, Zaozao, Leong, Kam W

“…Regeneration of diseased tissue is one of the foremost concerns for millions of patients who suffer from tissue damage each year. Local delivery of cell-laden…”
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Importation of yellow fever into China: assessing travel patterns by Wilder-Smith, Annelies, Leong, W Y

“…Rapid increase in trade and a growing air passenger market encourages high travel volume between the regions associated with increasing risks of such…”
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Microfluidic Isolation and Enrichment of Nanoparticles by Xie, Yuliang, Rufo, Joseph, Zhong, Ruoyu, Rich, Joseph, Li, Peng, Leong, Kam W, Huang, Tony Jun

“…Over the past decades, nanoparticles have increased in implementation to a variety of applications ranging from high-efficiency electronics to targeted drug…”
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Aptamer Nanomedicine for Cancer Therapeutics: Barriers and Potential for Translation by Lao, Yeh-Hsing, Phua, Kyle K.L, Leong, Kam W

“…Aptamer nanomedicine, including therapeutic aptamers and aptamer nanocomplexes, is beginning to fulfill its potential in both clinical trials and preclinical…”
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Biophysical Regulation of Cell Behavior-Cross Talk between Substrate Stiffness and Nanotopography by Yang, Yong, Wang, Kai, Gu, Xiaosong, Leong, Kam W.

“…The stiffness and nanotopographical characteristics of the extracellular matrix （ECM） influence numerous developmental, physiological, and pathological…”
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Scalable fabrication of size-controlled chitosan nanoparticles for oral delivery of insulin by He, Zhiyu, Santos, Jose Luis, Tian, Houkuan, Huang, Huahua, Hu, Yizong, Liu, Lixin, Leong, Kam W, Chen, Yongming, Mao, Hai-Quan

“…Abstract Controlled delivery of protein would find diverse therapeutic applications. Formulation of protein nanoparticles by polyelectrolyte complexation…”
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Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide by Wang, Hong-Xia, Song, Ziyuan, Lao, Yeh-Hsing, Xu, Xin, Gong, Jing, Cheng, Du, Chakraborty, Syandan, Park, Ji Sun, Li, Mingqiang, Huang, Dantong, Yin, Lichen, Cheng, Jianjun, Leong, Kam W.

“…Effective and safe delivery of the CRISPR/Cas9 gene-editing elements remains a challenge. Here we report the development of PEGylated nanoparticles (named…”
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Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation by Liang, Huiyi, Peng, Bo, Dong, Cong, Liu, Lixin, Mao, Jiaji, Wei, Song, Wang, Xinlu, Xu, Hanshi, Shen, Jun, Mao, Hai-Quan, Gao, Xiaohu, Leong, Kam W., Chen, Yongming

“…Cell-free DNA (cfDNA) released from damaged or dead cells can activate DNA sensors that exacerbate the pathogenesis of rheumatoid arthritis (RA). Here we show…”
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Spatial epigenome–transcriptome co-profiling of mammalian tissues by Zhang, Di, Deng, Yanxiang, Kukanja, Petra, Agirre, Eneritz, Bartosovic, Marek, Dong, Mingze, Ma, Cong, Ma, Sai, Su, Graham, Bao, Shuozhen, Liu, Yang, Xiao, Yang, Rosoklija, Gorazd B., Dwork, Andrew J., Mann, J. John, Leong, Kam W., Boldrini, Maura, Wang, Liya, Haeussler, Maximilian, Raphael, Benjamin J., Kluger, Yuval, Castelo-Branco, Gonçalo, Fan, Rong

“…Emerging spatial technologies, including spatial transcriptomics and spatial epigenomics, are becoming powerful tools for profiling of cellular states in the…”
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Biomaterialomics: Data science-driven pathways to develop fourth-generation biomaterials by Basu, Bikramjit, Gowtham, N.H., Xiao, Yang, Kalidindi, Surya R., Leong, Kam W.

“…Conventional approaches to developing biomaterials and implants require intuitive tailoring of manufacturing protocols and biocompatibility assessment. This…”
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The effect of the alignment of electrospun fibrous scaffolds on Schwann cell maturation by Chew, Sing Yian, Mi, Ruifa, Hoke, Ahmet, Leong, Kam W

“…Abstract Peripheral nerve regeneration can be enhanced by the stimulation of formation of bands of Büngner prior to implantation. Aligned electrospun poly( ε…”
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Cytokine activation induces human memory-like NK cells by Romee, Rizwan, Schneider, Stephanie E., Leong, Jeffrey W., Chase, Julie M., Keppel, Catherine R., Sullivan, Ryan P., Cooper, Megan A., Fehniger, Todd A.

“…Natural killer (NK) cells are lymphocytes that play an important role in the immune response to infection and malignancy. Recent studies in mice have shown…”
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pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities by Zhang, Jinming, Li, Jingjing, Shi, Zhi, Yang, Yang, Xie, Xi, Lee, Simon MingYuen, Wang, Yitao, Leong, Kam W., Chen, Meiwan

“…[Display omitted] Co-delivery of multiple drugs with complementary anticancer mechanisms by nano-carriers offers an effective strategy to treat cancer. The…”
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Engineering Cell Membrane‐Based Nanotherapeutics to Target Inflammation by Yan, Huize, Shao, Dan, Lao, Yeh‐Hsing, Li, Mingqiang, Hu, Hanze, Leong, Kam W.

“…Inflammation is ubiquitous in the body, triggering desirable immune response to defend against dangerous signals or instigating undesirable damage to cells and…”
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