Search Results - "Leong, Stanley P"
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1
Is Breast Cancer the Same Disease in Asian and Western Countries?
Published in World journal of surgery (01-10-2010)“…A mini-symposium was held in Montreal, Canada, at the International Surgical Week for the Breast Surgical International in 2007 addressing the question whether…”
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2
Clinicopathologic Predictors of Sentinel Lymph Node Metastasis in Thin Melanoma
Published in Journal of clinical oncology (10-12-2013)“…Indications for sentinel lymph node biopsy (SLNB) for thin melanoma are continually evolving. We present a large multi-institutional study to determine factors…”
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3
Survival and clinical outcomes of patients with melanoma brain metastasis in the era of checkpoint inhibitors and targeted therapies
Published in BMC cancer (27-04-2018)“…Melanoma brain metastasis is associated with an extremely poor prognosis, with a median overall survival of 4-5 months. Since 2011, the overall survival of…”
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Multivariate Analysis of Prognostic Factors Among 2,313 Patients With Stage III Melanoma: Comparison of Nodal Micrometastases Versus Macrometastases
Published in Journal of clinical oncology (10-05-2010)“…To determine the survival rates and independent predictors of survival using a contemporary international cohort of patients with stage III melanoma. Complete…”
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5
Prognostic Significance of Mitotic Rate in Localized Primary Cutaneous Melanoma: An Analysis of Patients in the Multi-Institutional American Joint Committee on Cancer Melanoma Staging Database
Published in Journal of clinical oncology (01-06-2011)“…The aim of this study was to assess the independent prognostic value of primary tumor mitotic rate compared with other clinical and pathologic features of…”
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6
Combined Analysis of Phase III Trials Evaluating [99mTc]Tilmanocept and Vital Blue Dye for Identification of Sentinel Lymph Nodes in Clinically Node-Negative Cutaneous Melanoma
Published in Annals of surgical oncology (01-02-2013)“…Background [ 99m Tc]Tilmanocept is a CD206 receptor-targeted radiopharmaceutical designed for sentinel lymph node (SLN) identification. Two nearly identical…”
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7
Prevalence of Homologous Recombination Pathway Gene Mutations in Melanoma: Rationale for a New Targeted Therapeutic Approach
Published in Journal of investigative dermatology (01-08-2021)“…Homologous recombination DNA damage repair (HR-DDR) deficient patients with various solid tumors have been treated with PARP inhibitors. However, the clinical…”
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8
Tumour-induced immune modulation of sentinel lymph nodes
Published in Nature reviews. Immunology (01-09-2006)“…Sentinel lymph nodes (SLNs), being the first nodes to receive lymph from a primary tumour and the preferential site of initial tumour metastases, are…”
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9
Is Head and Neck Melanoma Different from Trunk and Extremity Melanomas with Respect to Sentinel Lymph Node Status and Clinical Outcome?
Published in Annals of surgical oncology (01-09-2013)“…Background Previous studies showed conflicting and inconsistent results regarding the effect of anatomic location of the melanoma on sentinel lymph node (SLN)…”
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10
Micrometastatic cancer cells in lymph nodes, bone marrow, and blood: Clinical significance and biologic implications
Published in CA: a cancer journal for clinicians (01-05-2014)“…Answer questions and earn CME/CNE Cancer metastasis may be regarded as a progressive process from its inception in the primary tumor microenvironment to…”
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11
Higher Nodal expression is often associated with poorer survival in patients diagnosed with melanoma and treated with anti-PD1 therapy
Published in Pathology oncology research (23-09-2024)“…Advanced melanoma is considered the most aggressive and deadly form of skin cancer whose incidence has been rising over the past three decades. In the absence…”
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12
The Gene Expression Signatures of Melanoma Progression
Published in Proceedings of the National Academy of Sciences - PNAS (26-04-2005)“…Because of the paucity of available tissue, little information has previously been available regarding the gene expression profiles of primary melanomas. To…”
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Lymphoscintigraphy Using Tilmanocept Detects Multiple Sentinel Lymph Nodes in Melanoma Patients
Published in Cancer control (01-01-2023)“…Background Technetium-99m-labeled Tilmanocept, a multivalent mannose, is readily internalized by the CD206 surface receptor on macrophages and dendritic cells…”
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14
The role of BPTF in melanoma progression and in response to BRAF-targeted therapy
Published in JNCI : Journal of the National Cancer Institute (01-05-2015)“…Bromodomain PHD finger transcription factor (BPTF) plays an important role in chromatin remodeling, but its functional role in tumor progression is…”
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Analysis of sentinel lymph node positivity in patients with thin primary melanoma
Published in Journal of the American Academy of Dermatology (01-04-2013)“…Background A minority of patients with T1 melanoma will have a positive sentinel lymph node (SLN) biopsy (SLNB) finding. Identifying who will develop…”
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16
Immune responses and immunotherapeutic approaches in the treatment against cancer
Published in Clinical & experimental metastasis (01-08-2024)“…Cancer cells within a population are heterogeneous due to genomic mutations or epigenetic changes. The immune response to cancer especially the T cell…”
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Prospective Validation of Molecular Prognostic Markers in Cutaneous Melanoma: A Correlative Analysis of E1690
Published in Clinical cancer research (15-11-2017)“…To validate the prognostic impact of combined expression levels of three markers (SPP1, RGS1, and NCOA3) in melanoma specimens from patients enrolled in the…”
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Detection of melanoma, breast cancer and head and neck squamous cell cancer sentinel lymph nodes by Tc-99m Tilmanocept (Lymphoseek®)
Published in Clinical & experimental metastasis (01-02-2022)“…Technetium-99m-labeled Tilmanocept or Lymphoseek® (Cardinal Health, Dublin, Ohio) is a soluble, synthetic molecule with a small diameter (7 nm), which is…”
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Factors Predictive of the Status of Sentinel Lymph Nodes in Melanoma Patients from a Large Multicenter Database
Published in Annals of surgical oncology (01-12-2011)“…Background Numerous predictive factors for cutaneous melanoma metastases to sentinel lymph nodes have been identified; however, few have been found to be…”
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Compartmentalizing sentinel lymph nodes and nonsentinel lymph nodes in regional lymph nodes draining the primary melanoma
Published in JAMA surgery (01-09-2013)Get more information
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