Search Results - "Leong, Renee"

Antibody repertoire analysis of mouse immunization protocols using microfluidics and molecular genomics by Asensio, Michael A, Lim, Yoong Wearn, Wayham, Nicholas, Stadtmiller, Kacy, Edgar, Robert C, Leong, Jackson, Leong, Renee, Mizrahi, Rena A, Adams, Matthew S, Simons, Jan Fredrik, Spindler, Matthew J, Johnson, David S, Adler, Adam S

“…Immunization of mice followed by hybridoma or B-cell screening is one of the most common antibody discovery methods used to generate therapeutic monoclonal…”
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Preferential Identification of Agonistic OX40 Antibodies by Using Cell Lysate to Pan Natively Paired, Humanized Mouse-Derived Yeast Surface Display Libraries by Medina-Cucurella, Angélica, Mizrahi, Rena, Asensio, Michael, Edgar, Robert, Leong, Jackson, Leong, Renee, Lim, Yoong, Nelson, Ayla, Niedecken, Ariel, Simons, Jan, Spindler, Matthew, Stadtmiller, Kacy, Wayham, Nicholas, Adler, Adam, Johnson, David

“…To discover therapeutically relevant antibody candidates, many groups use mouse immunization followed by hybridoma generation or B cell screening. One modern…”
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Rare, high-affinity anti-pathogen antibodies from human repertoires, discovered using microfluidics and molecular genomics by Adler, Adam S, Mizrahi, Rena A, Spindler, Matthew J, Adams, Matthew S, Asensio, Michael A, Edgar, Robert C, Leong, Jackson, Leong, Renee, Roalfe, Lucy, White, Rebecca, Goldblatt, David, Johnson, David S

“…Affinity-matured, functional anti-pathogen antibodies are present at low frequencies in natural human repertoires. These antibodies are often excellent…”
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A natively paired antibody library yields drug leads with higher sensitivity and specificity than a randomly paired antibody library by Adler, Adam S, Bedinger, Daniel, Adams, Matthew S, Asensio, Michael A, Edgar, Robert C, Leong, Renee, Leong, Jackson, Mizrahi, Rena A, Spindler, Matthew J, Bandi, Srinivasa Rao, Huang, Haichun, Tawde, Pallavi, Brams, Peter, Johnson, David S

“…Deep sequencing and single-chain variable fragment (scFv) yeast display methods are becoming more popular for discovery of therapeutic antibody candidates in…”
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Rare, high-affinity mouse anti-PD-1 antibodies that function in checkpoint blockade, discovered using microfluidics and molecular genomics by Adler, Adam S, Mizrahi, Rena A, Spindler, Matthew J, Adams, Matthew S, Asensio, Michael A, Edgar, Robert C, Leong, Jackson, Leong, Renee, Johnson, David S

“…Conventionally, mouse hybridomas or well-plate screening are used to identify therapeutic monoclonal antibody candidates. In this study, we present an…”
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1389 GIGA-564 a third generation anti CTLA 4 with minimal ability to block CTLA 4 binding to B7 ligands has enhanced efficacy but reduced toxicity compared to ipilimumab in preclinical models by Stone, Erica, Carter, Kyle, Wagner, Ellen, Asensio, Michael, Benzie, Emily, Chiang, Yao, Coles, Garry, Edgar, Chelsea, Bishal Gautam, Gras, Ashley, Jackson, Leong, Leong, Renee, Manickam, Vishal, Mizrahi, Rena, Niedecken, Ariel, Saini, Jasmeen, Sandhu, Savreet, Simons, Jan Fredrick, Stadtmiller, Kacy, Tinsley, Brendan, LaRee Tracy, Wayham, Nicholas, Yoong Wearn Lim, Johnson, David, Adler, Adam

“…BackgroundAnti-CTLA-4 antibodies such as ipilimumab were among the first immuno-oncology agents to show significantly improved outcomes for patients. However,…”
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Antibody repertoire analysis of mouse immunization protocols using microfluidics and molecular genomics by Asensio, Michael A., Lim, Yoong Wearn, Wayham, Nicholas, Stadtmiller, Kacy, Edgar, Robert C., Leong, Jackson, Leong, Renee, Mizrahi, Rena A., Adams, Matthew S., Simons, Jan Fredrik, Spindler, Matthew J., Johnson, David S., Adler, Adam S.

“…Immunization of mice followed by hybridoma or B-cell screening is one of the most common antibody discovery methods used to generate therapeutic monoclonal…”
Get full text

Rare, high-affinity mouse anti-PD-1 antibodies that function in checkpoint blockade, discovered using microfluidics and molecular genomics by Adler, Adam S., Mizrahi, Rena A., Spindler, Matthew J., Adams, Matthew S., Asensio, Michael A., Edgar, Robert C., Leong, Jackson, Leong, Renee, Johnson, David S.

“…Conventionally, mouse hybridomas or well-plate screening are used to identify therapeutic monoclonal antibody candidates. In this study, we present an…”
Get full text

Rare, high-affinity anti-pathogen antibodies from human repertoires, discovered using microfluidics and molecular genomics by Adler, Adam S., Mizrahi, Rena A., Spindler, Matthew J., Adams, Matthew S., Asensio, Michael A., Edgar, Robert C., Leong, Jackson, Leong, Renee, Roalfe, Lucy, White, Rebecca, Goldblatt, David, Johnson, David S.

“…Affinity-matured, functional anti-pathogen antibodies are present at low frequencies in natural human repertoires. These antibodies are often excellent…”
Get full text