Search Results - "Leong, Khai Pang"

Robust SNP-based prediction of rheumatoid arthritis through machine-learning-optimized polygenic risk score by Lim, Ashley J W, Tyniana, C Tera, Lim, Lee Jin, Tan, Justina Wei Lynn, Koh, Ee Tzun, Chong, Samuel S, Khor, Chiea Chuen, Leong, Khai Pang, Lee, Caroline G

“…The popular statistics-based Genome-wide association studies (GWAS) have provided deep insights into the field of complex disorder genetics. However, its…”
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Medications impact different aspects of the quality of life of patients with systemic lupus erythematosus by Leong, Khai Pang, Tan, Joyce Ching‐Wen, Thong, Bernard Yu Hor, Lian, Tsui Yee, Koh, Ee Tzun, Kong, Kok Ooi, Law, Weng Giap, Chng, Hiok Hee, Chan, Grace Yin Lai, Chia, Faith Li‐Ann, Tan, Justina Wei Lynn, Howe, Hwee Siew, Chng, Hiok Hee, Howe, Hwee Siew, Koh, Ee Tzun, Kong, Kok Ooi, Lau, Tang Ching, Leong, Khai Pang, Thong, Bernard Yu‐Hor, Lian, Tsui Yee, Cheng, Yew Kuang, Teh, Cheng Lay, Badsha, Humeira, Law, Weng Giap, Chew, Li Ching, Yong, Wern Hui, Chia, Faith Li‐Ann, Chong, Eleen Yun Yin, Tan, Justina Wei Lynn

“…Purpose In this real‐world observational study, we analyzed the effects of different drugs on the quality of life (QoL) of patients with systemic lupus…”
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Consensus development on eligibility of government subsidisation of biologic disease modifying anti‐rheumatic agents for treatment of ankylosing spondylitis: The Singapore experience by Cheung, Peter P., Lahiri, Manjari, Teng, Gim‐Gee, Lui, Nai‐Lee, Chia, Faith L., Koh, Dow‐Rhoon, Koh, Wei‐Howe, Ng, Swee‐Cheng, Suresh, Ernest, Leong, Khai‐Pang, Lim, Anita Y. N., Thumboo, Julian, Lau, Tang‐Ching, Leong, Keng‐Hong

“…Introduction The beneficial effects of biologic disease‐modifying anti‐rheumatic drugs (bDMARDs), such as tumour necrosis factor inhibitors (anti‐TNF) in…”
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Singapore Chapter of Rheumatologists consensus statement on the eligibility for government subsidy of biologic disease modifying anti‐rheumatic agents for the treatment of psoriatic arthritis by Lahiri, Manjari, Teng, Gim‐Gee, Cheung, Peter P., Suresh, Ernest, Chia, Faith L., Lui, Nai‐Lee, Koh, Dow‐Rhoon, Koh, Wei‐Howe, Leong, Khai‐Pang, Lim, Anita Y. N., Ng, Swee‐Cheng, Thumboo, Julian, Lau, Tang‐Ching, Leong, Keng‐Hong

“…Aim In Singapore, patients with psoriatic arthritis (PsA) constitute a significant disease burden. There is good evidence for the efficacy of anti‐tumor…”
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Analysis of Genetic Variation in CYP450 Genes for Clinical Implementation by Goh, Liuh Ling, Lim, Chia Wei, Sim, Wey Cheng, Toh, Li Xian, Leong, Khai Pang

“…Genetic determinants of drug response remain stable throughout life and offer great promise to patient-tailored drug therapy. The adoption of pharmacogenetic…”
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2018 update of the APLAR recommendations for treatment of rheumatoid arthritis by Lau, Chak Sing, Chia, Faith, Dans, Leonila, Harrison, Andrew, Hsieh, Tsu Yi, Jain, Rahul, Jung, Seung Min, Kishimoto, Mitsumasa, Kumar, Ashok, Leong, Khai Pang, Li, Zhanguo, Lichauco, Juan Javier, Louthrenoo, Worawit, Luo, Shue Fen, Mu, Rong, Nash, Peter, Ng, Chin Teck, Suryana, Bagus, Wijaya, Linda Kurniaty, Yeap, Swan Sim

“…Aim To update recommendations based on current best evidence concerning the treatment of rheumatoid arthritis (RA), focusing particularly on the role of…”
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DUBStepR is a scalable correlation-based feature selection method for accurately clustering single-cell data by Ranjan, Bobby, Sun, Wenjie, Park, Jinyu, Mishra, Kunal, Schmidt, Florian, Xie, Ronald, Alipour, Fatemeh, Singhal, Vipul, Joanito, Ignasius, Honardoost, Mohammad Amin, Yong, Jacy Mei Yun, Koh, Ee Tzun, Leong, Khai Pang, Rayan, Nirmala Arul, Lim, Michelle Gek Liang, Prabhakar, Shyam

“…Feature selection (marker gene selection) is widely believed to improve clustering accuracy, and is thus a key component of single cell clustering pipelines…”
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Pregnancy loss and the risk of rheumatoid arthritis in Chinese women: findings from the China Kadoorie biobank by Hee, Jia Yi, Huang, Sha, Leong, Khai Pang, Chun, Li, Zhang, Yuxun Oswald, Gongye, Ruofan, Tang, Kun

“…Abstract Considering the female preponderance of rheumatoid arthritis (RA), and disease onset typically after the reproductive years, pregnancy and childbirth…”
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Pharmacogenomics and Rheumatological Practice by Xu, Chuanhui, Leong, Khai Pang

“…Pharmacogenomics, the study of the effect of genetics on the variation in drug response, is designed to maximize drug efficacy and minimize adverse effects. It…”
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TPMT and NUDT15 testing for thiopurine therapy: A major tertiary hospital experience and lessons learned by Goh, Liuh Ling, Lim, Chia Wei, Leong, Khai Pang, Ong, Kiat Hoe

“…Variants in thiopurine methyltransferase ( TPMT ) and nudix hydrolase 15 ( NUDT15 ) are associated with an accumulation of cytotoxic metabolites leading to…”
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Validating two international warfarin pharmacogenetic dosing algorithms for estimating the maintenance dose for patients in Singapore by Soh, Stephanie Pei Yun, See Toh, Wei Yann, Ten, Wei Qing, Leong, Khai Pang, Goh, Liuh Ling

“…Predicting optimal warfarin dosing is difficult due to complex pharmacodynamics and pharmacokinetics, narrow therapeutic index and susceptibility to many…”
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Clinical utility of anti-DFS70 for identifying antinuclear antibody-positive patients without systemic autoimmune rheumatic disease by Tan, Teck Choon, Ng, Carol Yee Leng, Leong, Khai Pang

“…The antinuclear antibody (ANA) test is a screening test for systemic autoimmune rheumatic disease (SARD). We hypothesised that the presence of anti-DFS70 in…”
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Broad Susceptibility of Nucleolar Proteins and Autoantigens to Complement C1 Protease Degradation by Cai, Yitian, Wee, Seng Yin Kelly, Chen, Junjie, Teo, Boon Heng Dennis, Ng, Yee Leng Carol, Leong, Khai Pang, Lu, Jinhua

“…Anti-nuclear autoantibodies, which frequently target the nucleoli, are pathogenic hallmarks of systemic lupus erythematosus (SLE). Although the causes of these…”
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The axis of complement C1 and nucleolus in antinuclear autoimmunity by Wu, Shan, Chen, Junjie, Teo, Boon Heng Dennis, Wee, Seng Yin Kelly, Wong, Ming Hui Millie, Cui, Jianzhou, Chen, Jinmiao, Leong, Khai Pang, Lu, Jinhua

“…Antinuclear autoantibodies (ANA) are heterogeneous self-reactive antibodies that target the chromatin network, the speckled, the nucleoli, and other nuclear…”
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Tensor-Based Methods for Handling Missing Data in Quality-of-Life Questionnaires by Garg, Lalit, Dauwels, Justin, Earnest, Arul, Khai Pang Leong

“…A common problem with self-report quality-of-life questionnaires is missing data. Despite enormous care and effort to prevent it, some level of missing data is…”
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APLAR rheumatoid arthritis treatment recommendations by Lau, Chak Sing, Chia, Faith, Harrison, Andrew, Hsieh, Tsu-Yi, Jain, Rahul, Jung, Seung Min, Kishimoto, Mitsumasa, Kumar, Ashok, Leong, Khai Pang, Li, Zhanguo, Lichauco, Juan Javier, Louthrenoo, Worawit, Luo, Shue-Fen, Nash, Peter, Ng, Chin Teck, Park, Sung-Hwan, Suryana, Bagus Putu Putra, Suwannalai, Parawee, Wijaya, Linda Kurniaty, Yamamoto, Kazuhiko, Yang, Yue, Yeap, Swan Sim

“…Aims Rheumatoid arthritis is a chronic inflammatory condition that affects approximately 1% of the world's population. There are a wide number of guidelines…”
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Pseudo-Anaphylactic Reactions to Pfizer BNT162b2 Vaccine: Report of 3 Cases of Anaphylaxis Post Pfizer BNT162b2 Vaccination by Lim, Xin Rong, Leung, Bernard Pui, Ng, Carol Yee Leng, Tan, Justina Wei Lynn, Chan, Grace Yin Lai, Loh, Chien Mei, Tan, Gwendolyn Li Xuan, Goh, Valerie Hui Hian, Wong, Lok To, Chua, Chong Rui, Tan, Sze Chin, Lee, Samuel Shang Ming, Howe, Hwee Siew, Thong, Bernard Yu Hor, Leong, Khai Pang

“…Anaphylactic reactions were observed after Singapore’s national coronavirus disease 2019 (COVID-19) vaccination programme started in December 2020. We report…”
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Conversion among the 28-joint count activity indices for rheumatoid arthritis by Leong, Khai Pang, Tan, Justina Wei Lynn, Gao, Xiao, Koh, Ee Tzun

“…Objective: Disease activity indices for rheumatoid arthritis (RA) are important in clinical practice and research. Although they are closely correlated, they…”
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Missense variant in interleukin-6 signal transducer identified as susceptibility locus for rheumatoid arthritis in Chinese patients by Leong, Khai Pang, Yong, Mei Yun, Goh, Liuh Ling, Woo, Chia Mun, Lim, Chia Wei, Koh, Ee Tzun

“…Objectives: This study aims to uncover variants of large effect size and allele frequency below 5% by sequencing all extant genes associated with rheumatoid…”
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Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid Arthritis by Leong, Khai Pang, Koh, Ee Tzun, Chan, Grace Yin Lai, Sakthiswary, Rajalingham, Thong, Bernard Yu Hor

“…Background. The aim of this study was to determine the risk factors of MTX-associated nonalcoholic fatty liver disease (NAFLD) with transaminitis in a cohort…”
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