Search Results - "Leong, Keith Weng Kit"
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Tyrosine Dephosphorylation of ASC Modulates the Activation of the NLRP3 and AIM2 Inflammasomes
Published in Frontiers in immunology (05-07-2019)“…The inflammasome is an intracellular multi-protein complex that orchestrates the release of the pro-inflammatory cytokines IL-1β and IL-18, and a form of cell…”
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Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis
Published in Scientific reports (31-07-2017)“…Large molecular complexes known as inflammasomes regulate the release of IL-1β from immune cells in response to infection and injury. Salmonella typhimurium…”
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Visualising cancer in 3D: 3‐Dimensional Tissue Imaging for management of cutaneous basal cell carcinoma
Published in Experimental dermatology (01-06-2024)“…Surgical management of basal cell carcinoma (BCC) typically involves surgical excision with post‐operative margin assessment using the bread‐loafing technique;…”
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The Inflammasome Adaptor ASC Intrinsically Limits CD4 + T-Cell Proliferation to Help Maintain Intestinal Homeostasis
Published in Frontiers in immunology (15-07-2019)“…The inflammasome is a multi-protein complex that mediates proteolytic cleavage and release of the pro-inflammatory cytokines IL-1β and IL-18, and pyroptosis-a…”
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NLRP10 Enhances CD4 + T-Cell-Mediated IFNγ Response via Regulation of Dendritic Cell-Derived IL-12 Release
Published in Frontiers in immunology (02-11-2017)“…NLRP10 is a nucleotide-binding oligomerization domain-like receptor that functions as an intracellular pattern recognition receptor for microbial products…”
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An Immunoregulatory Role for Complement Receptors in Murine Models of Breast Cancer
Published in Antibodies (Basel) (08-01-2021)“…The complement system has demonstrated roles in regulating tumor growth, although these may differ between tumor types. The current study used two murine…”
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