Search Results - "Leong, KW"

HTA148 PRIME: Does Accelerated Marketing Authorization Translate Into Expedited Reimbursement and Patient Access? by Macaulay, R, Leong, KW

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HTA11 Access Barrier or Opportunity? Evolving Trends in NRDL Listings in China by Macaulay, R, Leong, KW

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HTA57 UK Market Access: The Evolving Scope of NICE and NHSE Specialised Commissioning by Macaulay, R, Leong, KW

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HTA41 Consequences of Brexit: Medicines Access to Northern Ireland by Macaulay, R, Wang, GD, Leong, KW

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Spatial profiling of chromatin accessibility in mouse and human tissues by Deng, Yanxiang, Bartosovic, Marek, Ma, Sai, Zhang, Di, Kukanja, Petra, Xiao, Yang, Su, Graham, Liu, Yang, Qin, Xiaoyu, Rosoklija, Gorazd B., Dwork, Andrew J., Mann, J. John, Xu, Mina L., Halene, Stephanie, Craft, Joseph E., Leong, Kam W., Boldrini, Maura, Castelo-Branco, Gonçalo, Fan, Rong

“…Cellular function in tissue is dependent on the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context 1…”
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Spatial epigenome–transcriptome co-profiling of mammalian tissues by Zhang, Di, Deng, Yanxiang, Kukanja, Petra, Agirre, Eneritz, Bartosovic, Marek, Dong, Mingze, Ma, Cong, Ma, Sai, Su, Graham, Bao, Shuozhen, Liu, Yang, Xiao, Yang, Rosoklija, Gorazd B., Dwork, Andrew J., Mann, J. John, Leong, Kam W., Boldrini, Maura, Wang, Liya, Haeussler, Maximilian, Raphael, Benjamin J., Kluger, Yuval, Castelo-Branco, Gonçalo, Fan, Rong

“…Emerging spatial technologies, including spatial transcriptomics and spatial epigenomics, are becoming powerful tools for profiling of cellular states in the…”
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A materials-science perspective on tackling COVID-19 by Tang, Zhongmin, Kong, Na, Zhang, Xingcai, Liu, Yuan, Hu, Ping, Mou, Shan, Liljeström, Peter, Shi, Jianlin, Tan, Weihong, Kim, Jong Seung, Cao, Yihai, Langer, Robert, Leong, Kam W., Farokhzad, Omid C., Tao, Wei

“…The ongoing SARS-CoV-2 pandemic highlights the importance of materials science in providing tools and technologies for antiviral research and treatment…”
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Uniform Core–Shell Nanoparticles with Thiolated Hyaluronic Acid Coating to Enhance Oral Delivery of Insulin by Tian, Houkuan, He, Zhiyu, Sun, Chengxin, Yang, Chengbiao, Zhao, Pengfei, Liu, Lixin, Leong, Kam W., Mao, Hai‐Quan, Liu, Zhijia, Chen, Yongming

“…Oral delivery of protein drugs is an attractive route of administration due to its convenience for repeated dosing and good patient compliance. However,…”
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Multifunctional nanorods for gene delivery by Leong, Kam W, Salem, Aliasger K, Searson, Peter C

“…The goal of gene therapy is to introduce foreign genes into somatic cells to supplement defective genes or provide additional biological functions, and can be…”
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Sustained Release of Proteins from Electrospun Biodegradable Fibers by Chew, Sing Yian, Wen, Jie, Yim, Evelyn K. F, Leong, Kam W

“…Electrospinning is a simple and versatile technique of producing polymeric fibers ranging from submicron to micron in diameter. Incorporation of bioactive…”
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Controlled release of heparin from poly( ε-caprolactone) electrospun fibers by Luong-Van, Emma, Grøndahl, Lisbeth, Chua, Kian Ngiap, Leong, Kam W., Nurcombe, Victor, Cool, Simon M.

“…Sustained delivery of heparin to the localized adventitial surface of grafted blood vessels has been shown to prevent the vascular smooth muscle cell (VSMC)…”
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Biomedical applications of polymer-composite materials: a review by Ramakrishna, S, Mayer, J, Wintermantel, E, Leong, Kam W

“…An overview of various biomedical applications of polymer-composite materials reported in the literature over the last 30 years is presented in this paper. For…”
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Nanopattern-induced changes in morphology and motility of smooth muscle cells by Yim, Evelyn K.F., Reano, Ron M., Pang, Stella W., Yee, Albert F., Chen, Christopher S., Leong, Kam W.

“…Cells are known to be surrounded by nanoscale topography in their natural extracellular environment. The cell behavior, including morphology, proliferation,…”
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Polyphosphoesters in drug and gene delivery by Zhao, Zhong, Wang, Jun, Mao, Hai-Quan, Leong, Kam W

“…Polymers with repeating phosphoester bonds in the backbone are structurally versatile, and biodegradable through hydrolysis, and possibly enzymatic digestion…”
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The role of electrospinning in the emerging field of nanomedicine by Chew, S Y, Wen, Y, Dzenis, Y, Leong, K W

“…The fact that in vivo the extracellular matrix (ECM) or substratum with which cells interact often includes topography at the nanoscale underscores the…”
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The effect of the degree of chitosan deacetylation on the efficiency of gene transfection by Kiang, Tina, Wen, Jie, Lim, Huay Wen, Leong, Kam W.

“…Chitosans with various degrees of deacetylation were synthesized by acetylation with acetic anhydride. These chitosans were evaluated for efficacy of…”
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PEI-g-chitosan, a Novel Gene Delivery System with Transfection Efficiency Comparable to Polyethylenimine in Vitro and after Liver Administration in Vivo by Wong, Kokhou, Sun, Guobin, Zhang, Dai, Hui, Liu, Ye, He, Leong, Kam W

“…Polyethylenimine-graft-chitosan (PEI-g-chitosan) was synthesized by performing cationic polymerization of aziridine in the presence of water-soluble…”
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Temperature-responsive hydroxybutyl chitosan for the culture of mesenchymal stem cells and intervertebral disk cells by Dang, Jiyoung M., Sun, Daniel D.N., Shin-Ya, Yoshitsune, Sieber, Ann N., Kostuik, John P., Leong, Kam W.

“…Temperature-responsive polymers are attractive candidates for applications related to injectable delivery of biologically active therapeutics, such as stem…”
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Polyethylenimine-Grafted Multiwalled Carbon Nanotubes for Secure Noncovalent Immobilization and Efficient Delivery of DNA by Liu, Ye, Wu, De-Cheng, Zhang, Wei-De, Jiang, Xuan, He, Chao-Bin, Chung, Tai Shung, Goh, Suat Hong, Leong, Kam W.

“…DNA hits the wall: DNA is immobilized securely onto the surface of multiwalled carbon nanotubes through electrostatic interactions with grafted…”
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Aligned core-shell nanofibers delivering bioactive proteins by Liao, I C, Chew, S Y, Leong, K W

“…Continuous nanostructures embedded with proteins may synergistically present topographical and biochemical signals to cells for tissue engineering…”
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