Search Results - "Leong, John M."

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria by Rathinam, Vijay A.K., Vanaja, Sivapriya Kailasan, Waggoner, Lisa, Sokolovska, Anna, Becker, Christine, Stuart, Lynda M., Leong, John M., Fitzgerald, Katherine A.

“…Systemic infections with Gram-negative bacteria are characterized by high mortality rates due to the “sepsis syndrome,” a widespread and uncontrolled…”
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VlsE, the nexus for antigenic variation of the Lyme disease spirochete, also mediates early bacterial attachment to the host microvasculature under shear force by Tan, Xi, Lin, Yi-Pin, Pereira, Michael J, Castellanos, Mildred, Hahn, Beth L, Anderson, Phillip, Coburn, Jenifer, Leong, John M, Chaconas, George

“…Hematogenous dissemination is a critical step in the evolution of local infection to systemic disease. The Lyme disease (LD) spirochete, which efficiently…”
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Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic E. coli infection by Balasubramanian, Sowmya, Osburne, Marcia S, BrinJones, Haley, Tai, Albert K, Leong, John M

“…Enterohemorrhagic Escherichia coli (EHEC) colonize intestinal epithelium by generating characteristic attaching and effacing (AE) lesions. They are lysogenized…”
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The Yin and Yang of Pneumolysin During Pneumococcal Infection by Pereira, Joana M, Xu, Shuying, Leong, John M, Sousa, Sandra

“…Pneumolysin (PLY) is a pore-forming toxin produced by the human pathobiont , the major cause of pneumonia worldwide. PLY, a key pneumococcal virulence factor,…”
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Strain-specific joint invasion and colonization by Lyme disease spirochetes is promoted by outer surface protein C by Lin, Yi-Pin, Tan, Xi, Caine, Jennifer A, Castellanos, Mildred, Chaconas, George, Coburn, Jenifer, Leong, John M

“…Lyme disease, caused by Borrelia burgdorferi, B. afzelii and B. garinii, is a chronic, multi-systemic infection and the spectrum of tissues affected can vary…”
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Editorial overview of Pearls Microbiome Series: E pluribus unum by Hogan, Deborah A, Heitman, Joseph, Jabra-Rizk, Mary Ann, Knoll, Laura J, Leong, John M, Silverman, Neal

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Extracellular Adenosine Protects against Streptococcus pneumoniae Lung Infection by Regulating Pulmonary Neutrophil Recruitment by Bou Ghanem, Elsa N, Clark, Stacie, Roggensack, Sara E, McIver, Sally R, Alcaide, Pilar, Haydon, Philip G, Leong, John M

“…An important determinant of disease following Streptococcus pneumoniae (pneumococcus) lung infection is pulmonary inflammation mediated by polymorphonuclear…”
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Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome by Vanaja, Sivapriya Kailasan, Rathinam, Vijay A. K., Atianand, Maninjay K., Kalantari, Parisa, Skehan, Brian, Fitzgerald, Katherine A., Leong, John M.

“…Enterohemorrhagic Escherichia coli (EHEC) is an extracellular pathogen that causes hemorrhagic colitis and hemolytic uremic syndrome. The proinflammatory…”
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Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination by Lemieux, Jacob E, Huang, Weihua, Hill, Nathan, Cerar, Tjasa, Freimark, Lisa, Hernandez, Sergio, Luban, Matteo, Maraspin, Vera, Bogovič, Petra, Ogrinc, Katarina, Ruzič-Sabljič, Eva, Lapierre, Pascal, Lasek-Nesselquist, Erica, Singh, Navjot, Iyer, Radha, Liveris, Dionysios, Reed, Kurt D, Leong, John M, Branda, John A, Steere, Allen C, Wormser, Gary P, Strle, Franc, Sabeti, Pardis C, Schwartz, Ira, Strle, Klemen

“…Lyme disease is the most common vector-borne disease in North America and Europe. The clinical manifestations of Lyme disease vary based on the genospecies of…”
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Blocking HXA3-mediated neutrophil elastase release during S. pneumoniae lung infection limits pulmonary epithelial barrier disruption and bacteremia by Xu, Shuying, Tan, Shumin, Romanos, Patricia, Reedy, Jennifer L., Zhang, Yihan, Mansour, Michael K., Vyas, Jatin M., Mecsas, Joan, Mou, Hongmei, Leong, John M.

“…Streptococcus pneumoniae (Sp), a leading cause of community-acquired pneumonia, can spread from the lung into the bloodstream to cause septicemia and…”
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Strain-specific variation of the decorin-binding adhesin DbpA influences the tissue tropism of the lyme disease spirochete by Lin, Yi-Pin, Benoit, Vivian, Yang, Xiuli, Martínez-Herranz, Raúl, Pal, Utpal, Leong, John M

“…Lyme disease spirochetes demonstrate strain- and species-specific differences in tissue tropism. For example, the three major Lyme disease spirochete species,…”
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Systemic disease during Streptococcus pneumoniae acute lung infection requires 12-lipoxygenase-dependent inflammation by Bhowmick, Rudra, Maung, Nang, Hurley, Bryan P, Ghanem, Elsa Bou, Gronert, Karsten, McCormick, Beth A, Leong, John M

“…Acute pulmonary infection by Streptococcus pneumoniae is characterized by high bacterial numbers in the lung, a robust alveolar influx of polymorphonuclear…”
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Pearls collections: What we can learn about infectious disease and cancer by Knoll, Laura J, Hogan, Deborah A, Leong, John M, Heitman, Joseph, Condit, Richard C

“…[...]a contribution by Cattaneo and Russell probes the use and potential of viruses to treat cancer, using as an example a remarkable success story on the use…”
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Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly by Aitio, Olli, Hellman, Maarit, Kazlauskas, Arunas, Vingadassalom, Didier F., Leong, John M., Saksela, Kalle, Permi, Perttu, Kuriyan, John

“…Src homology 3 (SH3) domains are globular protein interaction modules that regulate cell behavior. The classic SH3 ligand-binding site accommodates a…”
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Enterohaemorrhagic Escherichia Coli Exploits a Tryptophan Switch to Hijack Host F-Actin Assembly by Aitio, Olli, Hellman, Maarit, Skehan, Brian, Kesti, Tapio, Leong, John M., Saksela, Kalle, Permi, Perttu

“…Intrinsically disordered protein (IDP)-mediated interactions are often characterized by low affinity but high specificity. These traits are essential in…”
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Allelic Variation of the Lyme Disease Spirochete Adhesin DbpA Influences Spirochetal Binding to Decorin, Dermatan Sulfate, and Mammalian Cells by BENOIT, Vivian M, FISCHER, Joshua R, LIN, Yi-Pin, PARVEEN, Nikhat, LEONG, John M

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The Alpha-Tocopherol Form of Vitamin E Boosts Elastase Activity of Human PMNs and Their Ability to Kill Streptococcus pneumoniae by Bou Ghanem, Elsa N, Lee, James N, Joma, Basma H, Meydani, Simin N, Leong, John M, Panda, Alexander

“…Despite the availability of vaccines, remains a leading cause of life-threatening infections, such as pneumonia, bacteremia and meningitis. Polymorphonuclear…”
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Enteropathogenic and enterohemorrhagic E. coli: ecology, pathogenesis, and evolution by Hartland, Elizabeth L, Leong, John M

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Actin pedestal formation by enterohemorrhagic Escherichia coli enhances bacterial host cell attachment and concomitant type III translocation by Battle, Scott E, Brady, Michael J, Vanaja, Sivapriya Kailasan, Leong, John M, Hecht, Gail A

“…Attachment of enterohemorrhagic Escherichia coli (EHEC) to intestinal epithelial cells is critical for colonization and is associated with localized actin…”
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Borrelia burgdorferi Lacking DbpBA Exhibits an Early Survival Defect during Experimental Infection by WEENING, Eric H, PARVEEN, Nikhat, TRZECIAKOWSKI, Jerome P, LEONG, John M, HÖÖK, Magnus, SKARE, Jonathan T

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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