Search Results - "Leong, Hui Sun"

Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy by Sharma, Ankur, Cao, Elaine Yiqun, Kumar, Vibhor, Zhang, Xiaoqian, Leong, Hui Sun, Wong, Angeline Mei Lin, Ramakrishnan, Neeraja, Hakimullah, Muhammad, Teo, Hui Min Vivian, Chong, Fui Teen, Chia, Shumei, Thangavelu, Matan Thangavelu, Kwang, Xue Lin, Gupta, Ruta, Clark, Jonathan R., Periyasamy, Giridharan, Iyer, N. Gopalakrishna, DasGupta, Ramanuj

“…Chemo-resistance is one of the major causes of cancer-related deaths. Here we used single-cell transcriptomics to investigate divergent modes of…”
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A KRAS-responsive long non-coding RNA controls microRNA processing by Shi, Lei, Magee, Peter, Fassan, Matteo, Sahoo, Sudhakar, Leong, Hui Sun, Lee, Dave, Sellers, Robert, Brullé-Soumaré, Laura, Cairo, Stefano, Monteverde, Tiziana, Volinia, Stefano, Smith, Duncan D., Di Leva, Gianpiero, Galuppini, Francesca, Paliouras, Athanasios R., Zeng, Kang, O’Keefe, Raymond, Garofalo, Michela

“…Wild-type KRAS ( KRAS WT ) amplification has been shown to be a secondary means of KRAS activation in cancer and associated with poor survival. Nevertheless,…”
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Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia by Deb, Gauri, Wingelhofer, Bettina, Amaral, Fabio M. R., Maiques-Diaz, Alba, Chadwick, John A., Spencer, Gary J., Williams, Emma L., Leong, Hui-Sun, Maes, Tamara, Somervaille, Tim C. P.

“…The histone demethylase lysine-specific demethylase 1 (LSD1 or KDM1A) has emerged as a candidate therapeutic target in acute myeloid leukaemia (AML);…”
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Analysis of circulating cell-free DNA identifies KRAS copy number gain and mutation as a novel prognostic marker in Pancreatic cancer by Mohan, Sumitra, Ayub, Mahmood, Rothwell, Dominic G., Gulati, Sakshi, Kilerci, Bedirhan, Hollebecque, Antoine, Sun Leong, Hui, Smith, Nigel K., Sahoo, Sudhakar, Descamps, Tine, Zhou, Cong, Hubner, Richard A., McNamara, Mairéad G., Lamarca, Angela, Valle, Juan W., Dive, Caroline, Brady, Ged

“…Serial biopsy of pancreatic ductal adenocarcinoma (PDAC), to chart tumour evolution presents a significant challenge. We examined the utility of circulating…”
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Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time by Chia, Shumei, Low, Joo-Leng, Zhang, Xiaoqian, Kwang, Xue-Lin, Chong, Fui-Teen, Sharma, Ankur, Bertrand, Denis, Toh, Shen Yon, Leong, Hui-Sun, Thangavelu, Matan T., Hwang, Jacqueline S. G., Lim, Kok-Hing, Skanthakumar, Thakshayeni, Tan, Hiang-Khoon, Su, Yan, Hui Choo, Siang, Hentze, Hannes, Tan, Iain B. H., Lezhava, Alexander, Tan, Patrick, Tan, Daniel S. W., Periyasamy, Giridharan, Koh, Judice L. Y., Gopalakrishna Iyer, N., DasGupta, Ramanuj

“…Genomics-driven cancer therapeutics has gained prominence in personalized cancer treatment. However, its utility in indications lacking biomarker-driven…”
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Vulnerability of drug‐resistant EML4‐ALK rearranged lung cancer to transcriptional inhibition by Paliouras, Athanasios R, Buzzetti, Marta, Shi, Lei, Donaldson, Ian J, Magee, Peter, Sahoo, Sudhakar, Leong, Hui‐Sun, Fassan, Matteo, Carter, Matthew, Di Leva, Gianpiero, Krebs, Matthew G, Blackhall, Fiona, Lovly, Christine M, Garofalo, Michela

“…A subset of lung adenocarcinomas is driven by the EML4‐ALK translocation. Even though ALK inhibitors in the clinic lead to excellent initial responses,…”
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A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC) by Low, Joo-Leng, Lau, Dawn Pingxi, Zhang, Xiaoqian, Kwang, Xue-Lin, Rohatgi, Neha, Chan, Jane Vin, Chong, Fui-Teen, Wong, Stephen Qi Rong, Leong, Hui-Sun, Thangavelu, Matan Thangavelu, Rikka, Shivaji, Skanderup, Anders Martin Jacobsen, Tan, Daniel Shao Weng, Periyasamy, Giridharan, Koh, Judice Lie Yong, Iyer, N Gopalakrishna, DasGupta, Ramanuj

“…Overexpression of epidermal growth factor receptor (EGFR), and downstream pathway activation appears to be a common oncogenic driver in the majority of head…”
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Targeting Cancer Stem Cell Plasticity Through Modulation of Epidermal Growth Factor and Insulin‐Like Growth Factor Receptor Signaling in Head and Neck Squamous Cell Cancer by Leong, Hui Sun, Chong, Fui Teen, Sew, Pui Hoon, Lau, Dawn P., Wong, Bernice H., Teh, Bin-Tean, Tan, Daniel S.W., Iyer, N. Gopalakrishna

“…An in vitro system that recapitulates stem cell plasticity in head and neck squamous cell cancers (HNSCCs) was established and the factors that play a role in…”
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Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation by Tape, Christopher J., Ling, Stephanie, Dimitriadi, Maria, McMahon, Kelly M., Worboys, Jonathan D., Leong, Hui Sun, Norrie, Ida C., Miller, Crispin J., Poulogiannis, George, Lauffenburger, Douglas A., Jørgensen, Claus

“…Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells. Here, we show that oncogenic KRAS (KRASG12D) also regulates tumor…”
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Hit screening with multivariate robust outlier detection by Leong, Hui Sun, Zhang, Tianhui, Corrigan, Adam, Serrano, Alessia, Künzel, Ulrike, Mullooly, Niamh, Wiggins, Ceri, Wang, Yinhai, Novick, Steven

“…Hit screening, which involves the identification of compounds or targets capable of modulating disease-relevant processes, is an important step in drug…”
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Vasculogenic mimicry in small cell lung cancer by Williamson, Stuart C., Metcalf, Robert L., Trapani, Francesca, Mohan, Sumitra, Antonello, Jenny, Abbott, Benjamin, Leong, Hui Sun, Chester, Christopher P. E., Simms, Nicole, Polanski, Radoslaw, Nonaka, Daisuke, Priest, Lynsey, Fusi, Alberto, Carlsson, Fredrika, Carlsson, Anders, Hendrix, Mary J. C., Seftor, Richard E. B., Seftor, Elisabeth A., Rothwell, Dominic G., Hughes, Andrew, Hicks, James, Miller, Crispin, Kuhn, Peter, Brady, Ged, Simpson, Kathryn L., Blackhall, Fiona H., Dive, Caroline

“…Small cell lung cancer (SCLC) is characterized by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. We show that SCLC patients…”
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Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma by Tan, Daniel S W, Chong, Fui Teen, Leong, Hui Sun, Toh, Shen Yon, Lau, Dawn P, Kwang, Xue Lin, Zhang, Xiaoqian, Sundaram, Gopinath M, Tan, Gek San, Chang, Mei Mei, Chua, Boon Tin, Lim, Wan Teck, Tan, Eng Huat, Ang, Mei Kim, Lim, Tony K H, Sampath, Prabha, Chowbay, Balram, Skanderup, Anders J, DasGupta, Ramanuj, Iyer, N Gopalakrishna

“…A silent single-nucleotide variant (SNV) affecting the transcription of a long noncoding RNA (lncRNA EGFR-AS1) within the EGFR coding region alters the EGFR…”
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PDGFR-modulated miR-23b cluster and miR-125a-5p suppress lung tumorigenesis by targeting multiple components of KRAS and NF-kB pathways by Naidu, Srivatsava, Shi, Lei, Magee, Peter, Middleton, Justin D., Laganá, Alessandro, Sahoo, Sudhakar, Leong, Hui Sun, Galvin, Melanie, Frese, Kristopher, Dive, Caroline, Guzzardo, Vincenza, Fassan, Matteo, Garofalo, Michela

“…In NSCLC alterations in PDGF receptors are markers of worst prognosis and efficient targeting of these receptors is yet to be achieved. In this study, we…”
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High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations by Wu, Yu-Chang, Kipling, David, Leong, Hui Sun, Martin, Victoria, Ademokun, Alexander A., Dunn-Walters, Deborah K.

“…B-cell receptor (BCR) diversity is achieved centrally by rearrangement of Variable, Diversity, and Joining genes, and peripherally by somatic hypermutation and…”
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Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis by Quah, Hong Sheng, Cao, Elaine Yiqun, Suteja, Lisda, Li, Constance H., Leong, Hui Sun, Chong, Fui Teen, Gupta, Shilpi, Arcinas, Camille, Ouyang, John F., Ang, Vivian, Celhar, Teja, Zhao, Yunqian, Tay, Hui Chen, Chan, Jerry, Takahashi, Takeshi, Tan, Daniel S. W., Biswas, Subhra K., Rackham, Owen J. L., Iyer, N. Gopalakrishna

“…Profiling tumors at single-cell resolution provides an opportunity to understand complexities underpinning lymph-node metastases in head and neck squamous-cell…”
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KRAS induces lung tumorigenesis through microRNAs modulation by Shi, Lei, Middleton, Justin, Jeon, Young-Jun, Magee, Peter, Veneziano, Dario, Laganà, Alessandro, Leong, Hui-Sun, Sahoo, Sudhakar, Fassan, Matteo, Booton, Richard, Shah, Rajesh, Crosbie, Philip A. J., Garofalo, Michela

“…Oncogenic KRAS induces tumor onset and development by modulating gene expression via different molecular mechanisms. MicroRNAs (miRNAs) are small non-coding…”
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Genetic profiling of tumours using both circulating free DNA and circulating tumour cells isolated from the same preserved whole blood sample by Rothwell, Dominic G., Smith, Nigel, Morris, Daniel, Leong, Hui Sun, Li, Yaoyong, Hollebecque, Antoine, Ayub, Mahmood, Carter, Louise, Antonello, Jenny, Franklin, Lynsey, Miller, Crispin, Blackhall, Fiona, Dive, Caroline, Brady, Ged

“…Molecular information obtained from cancer patients' blood is an emerging and powerful research tool with immense potential as a companion diagnostic for…”
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Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia by Somerville, Tim D.D., Wiseman, Daniel H., Spencer, Gary J., Huang, Xu, Lynch, James T., Leong, Hui Sun, Williams, Emma L., Cheesman, Edmund, Somervaille, Tim C.P.

“…Through in silico and other analyses, we identified FOXC1 as expressed in at least 20% of human AML cases, but not in normal hematopoietic populations. FOXC1…”
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Text-based over-representation analysis of microarray gene lists with annotation bias by Leong, Hui Sun, Kipling, David

“…A major challenge in microarray data analysis is the functional interpretation of gene lists. A common approach to address this is over-representation analysis…”
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Paracrine Factors of Human Fetal MSCs Inhibit Liver Cancer Growth Through Reduced Activation of IGF-1R/PI3K/Akt Signaling by Yulyana, Yulyana, Ho, Ivy A W, Sia, Kian Chuan, Newman, Jennifer P, Toh, Xin Yi, Endaya, Berwini B, Chan, Jerry K Y, Gnecchi, Massimiliano, Huynh, Hung, Chung, Alexander Y F, Lim, Kiat Hon, Leong, Hui Sun, Iyer, Narayanan Gopalakrishna, Hui, Kam Man, Lam, Paula Y P

“…Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death in the world. The multikinase inhibitor sorafenib only demonstrated marginal…”
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