Search Results - "Leong, Chung Yan"

Antibacterial Spirotetronate Polyketides from an Actinomadura sp. Strain A30804 by Ching, Kuan-Chieh, Chin, Elaine J, Wibowo, Mario, Tan, Zann Y, Yang, Lay-Kien, Seow, Deborah C, Leong, Chung-Yan, Ng, Veronica W, Ng, Siew-Bee, Kanagasundaram, Yoganathan

“…Large scale cultivation and chemical investigation of an extract obtained from sp. resulted in the identification of six previously undescribed spirotetronates…”
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Natural Products from Singapore Soil-Derived Streptomycetaceae Family and Evaluation of Their Biological Activities by Chin, Elaine-Jinfeng, Ching, Kuan-Chieh, Tan, Zann Y, Wibowo, Mario, Leong, Chung-Yan, Yang, Lay-Kien, Ng, Veronica W P, Seow, Deborah C S, Kanagasundaram, Yoganathan, Ng, Siew-Bee

“…Natural products have long been used as a source of antimicrobial agents against various microorganisms. Actinobacteria are a group of bacteria best known to…”
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Antibacterial Thiopeptide GE2270-Congeners from Nonomuraea jiangxiensis by Ching, Kuan-Chieh, Chin, Elaine J, Wibowo, Mario, Tan, Zann Y, Yang, Lay-Kien, Seow, Deborah C, Leong, Chung-Yan, Ng, Veronica W, Ng, Siew-Bee, Kanagasundaram, Yoganathan

“…Thiopeptides are macrocyclic natural products with potent bioactivity. Nine new natural thiopeptides (1−9) were obtained from a Nonomuraea jiangxiensis…”
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Hypoculoside, a sphingoid base-like compound from Acremonium disrupts the membrane integrity of yeast cells by Alfatah, Mohammad, Wong, Jin Huei, Nge, Choy Eng, Kong, Kiat Whye, Low, Kia Ngee, Leong, Chung Yan, Crasta, Sharon, Munusamy, Madhaiyan, Chang, Amanda Mun Leng, Hoon, Shawn, Ng, Siew Bee, Kanagasundaram, Yoganathan, Arumugam, Prakash

“…We have isolated Hypoculoside, a new glycosidic amino alcohol lipid from the fungus Acremonium sp. F2434 belonging to the order Hypocreales and determined its…”
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Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2 by Somanadhan, Brinda, Kotturi, Santosh R, Yan Leong, Chung, Glover, Robert P, Huang, Yicun, Flotow, Horst, Buss, Antony D, Lear, Martin J, Butler, Mark S

“…A 384-well microtitre plate fluorescence cleavage assay was developed to identify inhibitors of the cysteine protease falcipain-2, an important antimalarial…”
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In-Silico Identified New Natural Sortase A Inhibitors Disrupt S. aureus Biofilm Formation by Thappeta, Kishore Reddy Venkata, Zhao, Li Na, Nge, Choy Eng, Crasta, Sharon, Leong, Chung Yan, Ng, Veronica, Kanagasundaram, Yoganathan, Fan, Hao, Ng, Siew Bee

“…Sortase A (SrtA) is a membrane-associated enzyme that anchors surface-exposed proteins to the cell wall envelope of Gram-positive bacteria such as . As SrtA is…”
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Enhancing armeniaspirols production through multi-level engineering of a native Streptomyces producer by Heng, Elena, Lim, Yi Wee, Leong, Chung Yan, Ng, Veronica W P, Ng, Siew Bee, Lim, Yee Hwee, Wong, Fong Tian

“…Nature has provided unique molecular scaffolds for applications including therapeutics, agriculture, and food. Due to differences in ecological environments…”
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Application of Cas12j for Streptomyces Editing by Tan, Lee Ling, Heng, Elena, Leong, Chung Yan, Ng, Veronica, Yang, Lay Kien, Seow, Deborah Chwee San, Koduru, Lokanand, Kanagasundaram, Yoganathan, Ng, Siew Bee, Peh, Guangrong, Lim, Yee Hwee, Wong, Fong Tian

“…In recent years, CRISPR-Cas toolboxes for editing have rapidly accelerated natural product discovery and engineering. However, Cas efficiencies are oftentimes…”
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Genomics-driven discovery of a biosynthetic gene cluster required for the synthesis of BII-Rafflesfungin from the fungus Phoma sp. F3723 by Sinha, Swati, Nge, Choy-Eng, Leong, Chung Yan, Ng, Veronica, Crasta, Sharon, Alfatah, Mohammad, Goh, Falicia, Low, Kia-Ngee, Zhang, Huibin, Arumugam, Prakash, Lezhava, Alexander, Chen, Swaine L, Kanagasundaram, Yoganathan, Ng, Siew Bee, Eisenhaber, Frank, Eisenhaber, Birgit

“…Phomafungin is a recently reported broad spectrum antifungal compound but its biosynthetic pathway is unknown. We combed publicly available Phoma genomes but…”
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Tandem mass spectral metabolic profiling of 54 actinobacterial strains and their 459 mutants by Tay, Dillon W. P., Tan, Lee Ling, Heng, Elena, Zulkarnain, Nadiah, Chin, Elaine Jinfeng, Tan, Zann Yi Qi, Leong, Chung Yan, Ng, Veronica Wee Pin, Yang, Lay Kien, Seow, Deborah C. S., Kanagasundaram, Yoganathan, Ng, Siew Bee, Lim, Yee Hwee, Wong, Fong Tian

“…Natural products encompass a diverse range of compounds with high impact applications in consumer care, agriculture and most notably, therapeutics. However,…”
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Chemical elicitation as an avenue for discovery of bioactive compounds from fungal endophytes by Munusamy, Madhaiyan, Ching, Kuan Chieh, Yang, Lay Kien, Crasta, Sharon, Gakuubi, Martin Muthee, Chee, Zhao Yan, Wibowo, Mario, Leong, Chung Yan, Kanagasundaram, Yoganathan, Ng, Siew Bee

“…The present study investigated the molecular phylogeny, antimicrobial and cytotoxic activities of fungal endophytes obtained from the A*STAR Natural Organism…”
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Identification and engineering of 32 membered antifungal macrolactone notonesomycins by Goh, Falicia, Zhang, Mingzi M, Lim, Tian Ru, Low, Kia Ngee, Nge, Choy Eng, Heng, Elena, Yeo, Wan Lin, Sirota, Fernanda L, Crasta, Sharon, Tan, Zann, Ng, Veronica, Leong, Chung Yan, Zhang, Huibin, Lezhava, Alexander, Chen, Swaine L, Hoon, Shawn S, Eisenhaber, Frank, Eisenhaber, Birgit, Kanagasundaram, Yoganathan, Wong, Fong T, Ng, Siew Bee

“…Notonesomycin A is a 32-membered bioactive glycosylated macrolactone known to be produced by Streptomyces aminophilus subsp. notonesogenes 647-AV1 and S…”
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Cost-effective hybrid long-short read assembly delineates alternative GC-rich Streptomyces hosts for natural product discovery by Heng, Elena, Tan, Lee Ling, Tay, Dillon W.P., Lim, Yee Hwee, Yang, Lay-Kien, Seow, Deborah C.S., Leong, Chung Yan, Ng, Veronica, Ng, Siew Bee, Kanagasundaram, Yoganathan, Wong, Fong Tian, Koduru, Lokanand

“…With the advent of rapid automated in silico identification of biosynthetic gene clusters (BGCs), genomics presents vast opportunities to accelerate natural…”
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Exploring a general multi-pronged activation strategy for natural product discovery in Actinomycetes by Tay, Dillon W. P., Tan, Lee Ling, Heng, Elena, Zulkarnain, Nadiah, Ching, Kuan Chieh, Wibowo, Mario, Chin, Elaine Jinfeng, Tan, Zann Yi Qi, Leong, Chung Yan, Ng, Veronica Wee Pin, Yang, Lay Kien, Seow, Deborah C. S., Lim, Yi Wee, Koh, Winston, Koduru, Lokanand, Kanagasundaram, Yoganathan, Ng, Siew Bee, Lim, Yee Hwee, Wong, Fong Tian

“…Natural products possess significant therapeutic potential but remain underutilized despite advances in genomics and bioinformatics. While there are approaches…”
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New Antiinfective and Human 5-HT2 Receptor Binding Natural and Semisynthetic Compounds from the Jamaican Sponge Smenospongia aurea by HU, Jin-Feng, SCHETZ, John A., KELLY, Michelle, PENG, Jiang-Nan, ANG, Kenny K. H., FLOTOW, Horst, LEONG, Chung Yan, NG, Siew Bee, BUSS, Antony D., WILKINS, Scott P., HAMANN, Mark T.

“…In addition to the sesquiterpene-phenol aureols (1), 6'-chloroaureol (2), and aureol acetate (3), eight indole alkaloids including the new…”
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Antibacterial Thiopeptide GE2270-Congeners from INonomuraea jiangxiensis/I by Ching, Kuan-Chieh, Chin, Elaine J, Wibowo, Mario, Tan, Zann Y, Yang, Lay-Kien, Seow, Deborah C, Leong, Chung-Yan, Ng, Veronica W, Ng, Siew-Bee, Kanagasundaram, Yoganathan

“…Thiopeptides are macrocyclic natural products with potent bioactivity. Nine new natural thiopeptides (1-9) were obtained from a Nonomuraea jiangxiensis…”
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Antibacterial Spirotetronate Polyketides from an IActinomadura/I sp. Strain A30804 by Ching, Kuan-Chieh, Chin, Elaine J, Wibowo, Mario, Tan, Zann Y, Yang, Lay-Kien, Seow, Deborah C, Leong, Chung-Yan, Ng, Veronica W, Ng, Siew-Bee, Kanagasundaram, Yoganathan

“…Large scale cultivation and chemical investigation of an extract obtained from Actimonadura sp. resulted in the identification of six previously undescribed…”
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Natural Products from Singapore Soil-Derived IStreptomycetaceae/I Family and Evaluation of Their Biological Activities by Chin, Elaine-Jinfeng, Ching, Kuan-Chieh, Tan, Zann Y, Wibowo, Mario, Leong, Chung-Yan, Yang, Lay-Kien, Ng, Veronica W. P, Seow, Deborah C. S, Kanagasundaram, Yoganathan, Ng, Siew-Bee

“…Natural products have long been used as a source of antimicrobial agents against various microorganisms. Actinobacteria are a group of bacteria best known to…”
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New High-Throughput Screening Identifies Compounds That Reduce Viability Specifically in Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation by Tan, Justin L., Li, Feng, Yeo, Joanna Z., Yong, Kol Jia, Bassal, Mahmoud A., Ng, Guo Hao, Lee, May Yin, Leong, Chung Yan, Tan, Hong Kee, Wu, Chan-shuo, Liu, Bee Hui, Chan, Tim H., Tan, Zi Hui, Chan, Yun Shen, Wang, Siyu, Lim, Zhi Han, Toh, Tan Boon, Hooi, Lissa, Low, Kia Ngee, Ma, Siming, Kong, Nikki R., Stein, Alicia J., Wu, Yue, Thangavelu, Matan T., Suzuki, Atsushi, Periyasamy, Giridharan, Asara, John M., Dan, Yock Young, Bonney, Glenn K., Chow, Edward K., Lu, Guo-Dong, Ng, Huck Hui, Kanagasundaram, Yoganathan, Ng, Siew Bee, Tam, Wai Leong, Tenen, Daniel G., Chai, Li

“…Some oncogenes encode transcription factors, but few drugs have been successfully developed to block their activity specifically in cancer cells. The…”
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Application of Cas12j for IStreptomyces/I Editing by Tan, Lee Ling, Heng, Elena, Leong, Chung Yan, Ng, Veronica, Yang, Lay Kien, Seow, Deborah Chwee San, Koduru, Lokanand, Kanagasundaram, Yoganathan, Ng, Siew Bee, Peh, Guangrong, Lim, Yee Hwee, Wong, Fong Tian

“…In recent years, CRISPR-Cas toolboxes for Streptomyces editing have rapidly accelerated natural product discovery and engineering. However, Cas efficiencies…”
Get full text