Search Results - "Leonetti, Francesco"

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds by Stefanachi, Angela, Leonetti, Francesco, Pisani, Leonardo, Catto, Marco, Carotti, Angelo

“…Many naturally occurring substances, traditionally used in popular medicines around the world, contain the coumarin moiety. Coumarin represents a privileged…”
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A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL) by Alberga, Domenico, Trisciuzzi, Daniela, Montaruli, Michele, Leonetti, Francesco, Mangiatordi, Giuseppe Felice, Nicolotti, Orazio

“…We present MuSSeL, a multifingerprint similarity search algorithm, able to predict putative drug targets for a given query small molecule as well as to return…”
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Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs by Graziano, Giovanni, Stefanachi, Angela, Contino, Marialessandra, Prieto-Díaz, Rubén, Ligresti, Alessia, Kumar, Poulami, Scilimati, Antonio, Sotelo, Eddy, Leonetti, Francesco

“…Multicomponent reactions (MCRs) have emerged as a powerful strategy in synthetic organic chemistry due to their widespread applications in drug discovery and…”
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Nonoccurrence of Lavrentiev gap for a class of functionals with nonstandard growth by De Filippis, Filomena, Leonetti, Francesco, Treu, Giulia

“…We consider the functional where satisfies a -growth condition with respect to and can be approximated by means of a suitable sequence of functions. We…”
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Strategies to Improve Cancer Immune Checkpoint Inhibitors Efficacy, Other Than Abscopal Effect: A Systematic Review by Longo, Vito, Brunetti, Oronzo, Azzariti, Amalia, Galetta, Domenico, Nardulli, Patrizia, Leonetti, Francesco, Silvestris, Nicola

“…Despite that the impact of immune checkpoint inhibitors on malignancies treatment is unprecedented, a lack of response to these molecules is observed in…”
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Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to by Carofiglio, Francesca, Trisciuzzi, Daniela, Gambacorta, Nicola, Leonetti, Francesco, Stefanachi, Angela, Nicolotti, Orazio

“…The fusion oncoprotein Bcr-Abl is an aberrant tyrosine kinase responsible for chronic myeloid leukemia and acute lymphoblastic leukemia. The auto-inhibition…”
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On the Hölder continuity for a class of vectorial problems by Cupini, Giovanni, Focardi, Matteo, Leonetti, Francesco, Mascolo, Elvira

“…In this paper we prove local Hölder continuity of vectorial local minimizers of special classes of integral functionals with rank-one and polyconvex…”
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Bcr-Abl Tyrosine Kinase Inhibitors in the Treatment of Pediatric CML by Carofiglio, Francesca, Lopalco, Antonio, Lopedota, Angela, Cutrignelli, Annalisa, Nicolotti, Orazio, Denora, Nunzio, Stefanachi, Angela, Leonetti, Francesco

“…The therapeutic approach to Chronic Myeloid Leukemia (CML) has changed since the advent of the tyrosine kinase inhibitor (TKI) imatinib, which was then…”
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Editorial: Coumarins: New synthetic approaches and new pharmacological applications by Stefanachi, Angela, Muncipinto, Giovanni, Leonetti, Francesco

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Small Molecules for the Treatment of Long-COVID-Related Vascular Damage and Abnormal Blood Clotting: A Patent-Based Appraisal by Samarelli, Francesco, Graziano, Giovanni, Gambacorta, Nicola, Graps, Elisabetta Anna, Leonetti, Francesco, Nicolotti, Orazio, Altomare, Cosimo Damiano

“…People affected by COVID-19 are exposed to, among others, abnormal clotting and endothelial dysfunction, which may result in deep vein thrombosis,…”
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Polyconvex functionals and maximum principle by Carozza, Menita, Esposito, Luca, Giova, Raffaella, Leonetti, Francesco

“…Let us consider continuous minimizers $ u : \bar \Omega \subset \mathbb{R}^n \to \mathbb{R}^n $ of <disp-formula> <tex-math id="FE1"> \begin{document}$…”
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Butterfly support for off diagonal coefficients and boundedness of solutions to quasilinear elliptic systems by Leonardi, Salvatore, Leonetti, Francesco, Rocha, Eugenio, Staicu, Vasile

“…We consider quasilinear elliptic systems in divergence form. In general, we cannot expect that weak solutions are locally bounded because of De Giorgi’s…”
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Absence of Lavrentiev gap for non-autonomous functionals with (p,q)-growth by Esposito Antonio, Leonetti Francesco, Petricca Pier Vincenzo

“…We consider non-autonomous functionals of the form ℱ⁢(u,Ω)=∫Ωf⁢(x,D⁢u⁢(x))⁢𝑑x{\mathcal{F}(u,\hskip-0.569055pt\Omega)\hskip-0.853583pt=\hskip-0.853583pt\int%…”
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Inflammatory Related Reactions in Humans and in Canine Breast Cancers, A Spontaneous Animal Model of Disease by Tricarico, Domenico, Convertino, Anna Sara, Mehmeti, Irsida, Ranieri, Girolamo, Leonetti, Francesco, Laface, Carmelo, Zizzo, Nicola

“…Inflammatory cells are emerging markers in various cancers in human trials. The relationship between the inflammatory cells response, cancer grade, and…”
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Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally Unique Specificities by Choe, Youngchool, Leonetti, Francesco, Greenbaum, Doron C., Lecaille, Fabien, Bogyo, Matthew, Brömme, Dieter, Ellman, Jonathan A., Craik, Charles S.

“…The substrate specificities of papain-like cysteine proteases (clan CA, family C1) papain, bromelain, and human cathepsins L, V, K, S, F, B, and five proteases…”
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A twenty-year journey exploring coumarin-based derivatives as bioactive molecules by Pisani, Leonardo, Catto, Marco, Muncipinto, Giovanni, Nicolotti, Orazio, Carrieri, Antonio, Rullo, Mariagrazia, Stefanachi, Angela, Leonetti, Francesco, Altomare, Cosimo

“…The coumarin core (i.e., 1-benzopyran-2 (2 H )-one) is a structural motif highly recurrent in both natural products and bioactive molecules. Indeed, depending…”
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Mapping the geographic origin of captive and confiscated Hermann’s tortoises: A genetic toolkit for conservation and forensic analyses by Biello, Roberto, Zampiglia, Mauro, Corti, Claudia, Deli, Gianluca, Biaggini, Marta, Crestanello, Barbara, Delaugerre, Michel, Di Tizio, Luciano, Leonetti, Francesco Luigi, Casari, Stefano, Olivieri, Oliviero, Pellegrino, Francesco, Romano, Antonio, Sperone, Emilio, Hauffe, Heidi Christine, Trabalza-Marinucci, Massimo, Bertorelle, Giorgio, Canestrelli, Daniele

“…•First toolkit to assist forensic genetic applications for the Hermann’s tortoise.•Six major genetic clusters found along the Mediterranean range.•More than…”
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Implementation of Experimental Design Techniques to Optimize Immunoglobulins Detection with Ultrasensitive Sandwich Immunoassays by Scandurra, Cecilia, Bollella, Paolo, Österbacka, Ronald, Leonetti, Francesco, Macchia, Eleonora, Torsi, Luisa

“…The ultrasensitive measurement of protein markers plays a pivotal role in the early diagnosis of infectious and progressive diseases. Recently, digital methods…”
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Fast and Reliable Electronic Assay of a Xylella fastidiosa Single Bacterium in Infected Plants Sap by Sarcina, Lucia, Macchia, Eleonora, Loconsole, Giuliana, D'Attoma, Giusy, Bollella, Paolo, Catacchio, Michele, Leonetti, Francesco, Di Franco, Cinzia, Elicio, Vito, Scamarcio, Gaetano, Palazzo, Gerardo, Boscia, Donato, Saldarelli, Pasquale, Torsi, Luisa

“…Pathogens ultra‐sensitive detection is vital for early diagnosis and provision of restraining actions and/or treatments. Among plant pathogens, Xylella…”
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The Community Pharmacy as a Study Center for the Epidemiological Analysis of the Population Vaccination against SARS-CoV-2: Evaluation of Vaccine Safety and Pharmaceutical Service by Dibenedetto, Jacopo Raffaele, Cetrone, Michela, Antonacci, Marina, Cannone, Domenico Pio, Antonacci, Stefania, Bratta, Pasquale, Leonetti, Francesco, Tricarico, Domenico

“…We conducted a monocentric observational study aimed at evaluating the vaccine safety and the pharmaceutical service provided at a community pharmacy (C.PHARM)…”
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